Allergy & Immunology

Bone marrow CCR3 dictates eosinophil lineage commitment of CD34⁺ progenitors to orchestrate allergic rhinitis: A composite study.

BACKGROUND: Allergic rhinitis (AR) is a common Th2-mediated inflammatory disease of the nasal mucosa, in which eosinophils serve as pivotal effector cells. The CCR3 receptor, specific for eotaxin, plays a critical role in allergic inflammation. However, the role of CCR3 in the differentiation of bone marrow CD34 ⁺ progenitor cells into eosinophils and its contribution to AR pathogenesis remains in...

Single-cell and multi-omics integration delineates the landscape of gene-wise intratumor heterogeneity and identifies prognostic biomarkers for immunotherapy in non-small cell lung cancer.

BACKGROUND: Gene-wise intratumor heterogeneity (ITH), defined as spatial variability in the expression of individual genes across tumor regions, remains incompletely characterized in non-small cell lung cancer (NSCLC). Identifying low-ITH genes as predictive biomarkers offers a promising strategy to enhance the reliability of immunotherapy outcome prediction. METHODS: We profiled gene-wise ITH usi...

2-Hydroxyisobutyrylation and Phosphorylation Crosstalk Guides Metastasis Prediction and Immunotherapy in Esophageal Squamous Cell Carcinoma.

Posttranslational modification (PTM) is pivotal in cancer progression. However, the mechanisms, biological function, and clinical significance underly...

A Pollen-Enhanced Bionic Mechanoreceptor Induced by Asymmetric Ionic Convection in Hydrogel for Sensory-Augmented Prostheses.

The growing prevalence of age-related limb loss underscores the need for prosthetic technologies that restore not only motor function but also authent...

Small Molecules: What makes them 'small' and why is that important? What can we expect?

Just when newer technologies threaten to render them obsolete, small molecule drugs are under way to becoming first-in-class drugs in allergy and immu...

Exploring the immune landscape and immunotherapy relevance of ER stress-related lncRNAs in melanoma through multi-omics and explainable machine learning.

BACKGROUND: Melanoma is a highly aggressive malignancy with poor clinical outcomes, and endoplasmic reticulum (ER) stress plays an important role in t...

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning.

BACKGROUND: Immunotherapy has shown limited efficacy in a substantial subset of CRC patients, yet the mechanisms underlying therapeutic resistance rem...

Body composition radiomics integrated with machine learning to predict prognosis in advanced NSCLC treated with first-line immunochemotherapy and concurrent radiotherapy.

OBJECTIVE: Adipose tissue is a highly heterogeneous and plastic endocrine and immune organ whose characteristics have been linked to prognosis in NSCL...

Pathway-level epigenetic modeling illuminates the methylation architecture to asthma risk across tissues.

BACKGROUND: Asthma is a clinically heterogeneous airway disorder characterized by complex interactions between environmental exposures, immune activat...

Determinants of Poor Health-Related Quality of Life in Patients With Food Allergy.

BACKGROUND: Food allergy (FA) significantly impairs health-related quality of life (HRQL), yet its key determinants remain unclear. This study aimed t...

Computational prediction of TCR cross-reactivity: principles, challenges and translational opportunities.

T-cell receptor (TCR) cross-reactivity, whereby a single TCR recognizes multiple peptide-MHC (pMHC) ligands, is essential for immune surveillance but ...

Deep Learning of CT Imaging Predicts PD-L1 Expression and Immunotherapy Response in Metastatic NSCLC: A Multi-Center Study.

Immune checkpoint inhibitors (ICIs) benefit only a subset of patients with metastatic non-small cell lung cancer (NSCLC), but current selection relies...

Mapping the TCR landscape: computational tools empowering translational immunology and therapy design.

T cell receptors (TCRs) are central to adaptive immunity, yet their vast sequence and structural diversity present a significant challenge to fully un...

Wearable sensor technology and machine learning for anterior cruciate ligament injury diagnosis: an exploratory feasibility study.

OBJECTIVES: To evaluate the feasibility of using wearable inertial measurement units (IMUs; small body-worn sensors that capture linear acceleration a...

Deep Learning vs. Traditional Machine Learning in the Diagnosis of Cutaneous Drug Eruptions: A Comparative Study with Explainable AI on Whole-Slide Images.

Histopathological diagnosis of cutaneous drug eruptions (CDEs) presents a challenge in dermatopathology due to morphological overlap and high inter-ob...

Effect of an electronic health record-integrated machine learning asthma risk marker on pediatrician prognostic accuracy during preschool age: a pilot randomized clinical trial.

Early identification of children at risk for persistent asthma is challenging because preschool respiratory symptoms are heterogeneous and often overl...

Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients.

BACKGROUND: Donor-specific antibodies (DSA) against human leukocyte antigens (HLA) are associated with increased immunologic risk in kidney transplant...

Scalable multiplexed machine learning gas sensor chips for food classification.

Multiplexed gas sensor arrays combined with machine learning have unlocked previously inaccessible applications for scent-based sensing. Current platf...

Machine learning discriminates bacterial, fungal, and viral infections using temporal blood analyte dynamics in bottlenose dolphins (Tursiops truncatus).

OBJECTIVE: To determine underlying infectious disease as bacterial, fungal, or viral in origin from longitudinal assessment of biochemistry and hemato...

Allergic rhinitis in the elderly. In collaboration with ARIA guidelines.

Rhinitis in the elderly represents a unique challenge, due to specific clinical profiles, needs and expectations. Allergic rhinitis (AR) in the elderl...