Allergy & Immunology

Latest AI and machine learning research in allergy & immunology for healthcare professionals.

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Mass cytometry data integration methods reveal rural-urban gradient of immune profiles across geography

The human immune system strongly varies across populations and is shaped by a wide range of host and environmental factors. As such, a rural compared to urban lifestyle has previously been associated with baseline differences in immune profiles, which can impact outcome of vaccination. The question whether there is a immune signature that associates with rural living irrespective of ancestry or ge...

Physically-Guided Optical Inversion Enable Non-Contact Side-Channel Attack on Isolated Screens

Noncontact exfiltration of electronic screen content poses a security challenge, with side-channel incursions as the principal vector. We introduce an optical projection side-channel paradigm that confronts two core instabilities: (i) the near-singular Jacobian spectrum of projection mapping breaches Hadamard stability, rendering inversion hypersensitive to perturbations; (ii) irreversible compres...

Apr 15 2026 2604.13419v1
Decoding by Perturbation: Mitigating MLLM Hallucinations via Dynamic Textual Perturbation

Multimodal Large Language Models frequently suffer from inference hallucinations, partially stemming from language priors dominating visual evidence. ...

Apr 14 2026 2604.12424v1
A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions

The interaction between T cell receptors (TCRs), peptides, and human leukocyte antigens (HLAs) underlies antigen-specific T cell immunity. Despite sub...

Transcriptomic Models for Immunotherapy Response Prediction Show Limited Cross-cohort Generalisability

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; yet substantial proportion of patients exhibit intrinsic or acquired resistance, ...

Apr 7 2026 2604.05478v1
Predicting COVID-19 incidence from seroprevalence and population-based cohort data using interpretable machine learning with differential privacy analysis

During the COVID-19 pandemic, reported incidence data played a central role in public health surveillance and in tracking epidemic dynamics, although ...

Grading of Erythema and Visual Attributes in Atopic Dermatitis across Diverse Skin Tones Using a Vision AI Pipeline

Background: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease associated with clinical, psychosocial, and economic burden. Accur...

Genome-Wide Variations of End Motif in Cell-Free DNA Fragments Distinguish Immunotherapy Responders from Non-Responders in Head and Neck Cancer: A Multi-Institute Prospective Study

Reliable, minimally invasive biomarkers for predicting immunotherapy response in head and neck squamous cell carcinoma (HNSCC) remain an unmet clinica...

IFN-γ Orchestrates Coordinated Immunosuppression in Head and Neck Squamous Cell Carcinoma Through JAK-STAT-IRF8 Signaling: A Transcriptome-Wide Computational Analysis

Background: Interferon-gamma (IFN-{gamma}) is the primary effector cytokine of adaptive anti-tumor immunity, yet it paradoxically induces a potent imm...

Generation Is Compression: Zero-Shot Video Coding via Stochastic Rectified Flow

Existing generative video compression methods use generative models only as post-hoc reconstruction modules atop conventional codecs. We propose \emph...

Mar 27 2026 2603.26571v1
Self-supervised learning for a gene program-centric view of cell states

Single-cell omics has extended the biological interrogation of cell state from examining the expression of individual genes to unbiased profiling of t...

MedAidDialog: A Multilingual Multi-Turn Medical Dialogue Dataset for Accessible Healthcare

Conversational artificial intelligence has the potential to assist users in preliminary medical consultations, particularly in settings where access t...

Mar 25 2026 2603.24132v1
When AI Shows Its Work, Is It Actually Working? Step-Level Evaluation Reveals Frontier Language Models Frequently Bypass Their Own Reasoning

Language models increasingly "show their work" by writing step-by-step reasoning before answering. But are these reasoning steps genuinely used, or de...

Mar 24 2026 2603.22816v1
Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

Regional lymph node (LN) metastasis critically influences distant metastatic progression, anti-tumour immunity, and patient prognosis. While tumour-in...

Rational Design of Selective IL-2-based Activators for CAR T Cells Using AlphaFold3 and Physics-Informed Machine Learning

Recombinant human Interleukin-2 (rhIL-2, Aldesleukin) is used in immunotherapy for metastatic melanoma and renal cell carcinoma. Low-dose IL-2 has bee...

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI

Identifying predictive biomarkers of immunotherapeutic response in melanoma remains an outstanding challenge. Existing transcriptomic and proteomic pr...

SwiftTCR: Efficient Computational Docking protocol of TCRpMHC-I Complexes Using Restricted Rotation Matrices

The T cell's ability to discern self and non-self depends on its T cell receptor (TCR), which recognizes peptides presented by MHC molecules. Understa...

Experimental multi-center validation of a radiomics-based photonic quantum precision medicine architecture for lesion-level prediction of anti-PD-1 response in non-small cell lung cancer

Background: Previous research has shown that radiomics-based machine learning models are promising precision medicine tools for lesion-level predictio...

A spatial multi-omic portrait of survival outcome for clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the leading cause of kidney cancer-related death, but how the tumor microenvironment shapes patient surviva...

Exposomics for childhood asthma

Identification of early interventions to reduce/eliminate asthma - the most common chronic disease among children - could significantly reduce burden ...

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