Alternative Medicine

Computational renaissance in herbal medicine: A 20-year bibliometric deciphering of molecular dynamics simulations reshaping traditional Chinese medicine drug discovery.

Molecular dynamics (MD) simulations have emerged as pivotal tools for deciphering the molecular mechanisms of Traditional Chinese Medicine (TCM), yet a comprehensive analysis of their global impact has not been conducted. We conducted a 20-year bibliometric analysis (2006-2025 December 31) of 6054 publications from the Web of Science Core Collection, Scopus and CNKI employing R packages and VOSvie...

Carpal Tunnel Syndrome Diagnosis: A Narrative Review of Complementary Roles of Neuromuscular Ultrasound and Electrodiagnostic Studies.

Carpal tunnel syndrome (CTS), the most prevalent entrapment neuropathy of the upper extremities, presents diagnostic challenges due to nonspecific clinical symptoms and discrepancies between subjective experiences and objective findings. Traditional reliance on electrodiagnostic studies (EDX), including nerve conduction studies (NCS) and electromyography, as the traditional reference method for as...

Integrative bioinformatics and machine learning identify shared molecular mechanisms and diagnostic biomarkers between Helicobacter pylori infection and atrial fibrillation.

BACKGROUND: Helicobacter pylori (H. pylori) infection and atrial fibrillation(AF) are major global health concerns. Emerging evidence has suggested a ...

HeFS: Helper-Enhanced Feature Selection via Pareto-Optimized Genetic Search.

INTRODUCTION: Feature selection plays a crucial role in improving predictive performance and interpretability in high-dimensional machine learning tas...

Explainable deep learning combined with SERS for simultaneous detection of nicotine and etomidate isomers in E-cigarettes.

The incorporation of illegal drugs into e-cigarettes poses significant threats to both human health and societal safety. Therefore, the development of...

ACAT1-mediated lactylation reprogramming governs immune-stromal crosstalk in ulcerative colitis.

Ulcerative colitis (UC), a chronic inflammatory bowel disorder characterized by progressive colonic inflammation, presents escalating global incidence...

Integrative assessment of sulfoxaflor effects on gene expression, reproduction, and behavior in the bumblebee Bombus impatiens.

Social insect pollinators, such as bumblebees, face increasing threats from environmental agrochemicals; yet the sublethal effects of these compounds ...

RxPairEvid and GraphFusion: Multimodal pharmacovigilance and mechanistic knowledge-graph evidence for drug-drug interaction prediction.

Drug-drug interactions (DDIs) are a major cause of preventable adverse drug reactions, yet experimental screening cannot keep pace with the growing nu...

Artificial Intelligence, Connected Care, and Enabling Digital Health Technologies in Rare Diseases With a Focus on Lysosomal Storage Disorders: Scoping Review.

BACKGROUND: Rare diseases affect more than 300 million people globally, and only about 5% have approved therapies. Lysosomal storage disorders (LSDs) ...

AI-Assisted Virtual Reality Simulation for Therapeutic Ambient Communication: An Integrative Review.

BACKGROUND: Artificial intelligence-enabled ambient speech recognition technology is an emerging innovation poised to transform how nurses care for an...

Bio-optimized complex valued spatiotemporal GNN for herbal species classification.

Herbs have long been integral to various health and medicinal benefits. Identifying the correct herb species from thousands of diverse options is a la...

Integrative Analysis Combining Machine Learning and Functional Experiments Uncovers ISG15 As a Key Determinant of Cisplatin Resistance in Gastric Cancer.

BACKGROUND/AIM: Cisplatin resistance remains a major obstacle in advanced gastric cancer (GC). This study aimed to identify key molecular determinants...

Exploring how deep learning decodes anomalous diffusion via Grad-CAM.

While deep learning has been successfully applied to the data-driven classification of anomalous diffusion mechanisms, how the algorithm achieves the ...

Dental Odontogenic Lesion CBCT and Histopathology Integrated Dataset for Benchmarking Deep Learning Algorithms.

Accurate diagnosis of odontogenic lesions requires pre-operative cone-beam computed tomography (CBCT) and post-operative histopathological confirmatio...

An improved dataset for predicting mammal infecting viruses from genetic sequence information.

There have been several attempts to develop machine learning (ML) models to identify human infecting viruses from their genomic sequences, with varyin...

Artificial intelligence and hearing health: a global evidence review of biases and equity implications for Africa.

Artificial intelligence (AI) is increasingly integrated into audiology and hearing health, yet evidence from across the health sciences shows that AI ...

Optimized Lightweight U-Net and YOLACT framework for multi-disease severity detection in pome fruit leaves.

The growing global demand for food production, coupled with the increasing threat of plant diseases, necessitates advanced and automated solutions for...

Preliminary evaluation of gunshot residue pattern analysis using flash-pulse infrared thermography and multi-task deep learning.

Gunshot residue pattern assessment can support forensic reconstruction, particularly for shooting distance evaluation, but commonly used approaches ma...

Path forward: Cryoablation for colorectal liver metastases.

PURPOSE: Colorectal liver metastases (CRLM) are a leading cause of mortality in patients with colorectal cancer. While surgical resection is the stand...

W1-SN2-BH: A Large-Scale CCSD(T)/CBS Kinetic Database.

We present the W1-SN2-BH database, a large-scale kinetic benchmark set of all-electron CCSD(T)/CBS reference barrier heights for 1881 nucleophilic sub...