Alternative Medicine

Radiolabeled drug-delivery and controlled-release nanocarriers for arthritis: Clinical evidence, kinetic modeling, radiation-safety challenges, and precision nanotheranostics.

BACKGROUND: Arthritis comprises a heterogeneous group of inflammatory and degenerative joint disorders characterized by distinct pathological mechanisms, anatomical targets, and therapeutic requirements. Although arthritis is not primarily a pharmacokinetic disorder, several pharmacokinetic and delivery barriers can limit treatment. These include rapid synovial-fluid turnover, vascular and lymphat...

Microbiome-metabolome multi-omics biomarkers for infectious disease prognosis: Current evidence, AI-driven integration, and translational challenges.

Microbiome-metabolome interactions are emerging as promising predictors of infectious disease, beyond conventional pathogen detection. Growing evidence shows that microbial dysbiosis, altered microbial-derived metabolites, and host metabolic reprogramming are associated with disease severity, immune dysfunction, treatment response, and mortality across infectious diseases. High-throughput sequenci...

Integrative transcriptomic and single-cell analysis identifies anoikis-related molecular signatures in vascular calcification.

BACKGROUND: Vascular calcification (VC) is a life-threatening complication of chronic kidney disease (CKD) driven by vascular smooth muscle cell (VSMC...

Artificial Intelligence Technology Enhancing Emergency Department Triage: An Integrative Review.

Accurate triage is vital in emergency departments, where misidentification delays care, increases morbidity and mortality, and strains resources, part...

An Umbrella Review of Artificial Intelligence Applications in Mental Health Care.

BACKGROUND: Artificial intelligence (AI) is increasingly used in mental health care to address rising demand, workforce shortages and access barriers;...

AI for tumour proportion scoring of programmed death-ligand 1 immunohistochemistry in non-small cell lung cancer: a review of commercial and non-commercial tools.

Programmed death-ligand 1 (PD-L1) expression, commonly quantified as tumour proportion score (TPS), is a key biomarker guiding immunotherapy in non-sm...

Super-resolution MRI and 2.5D deep learning for intratumoral-peritumoral radiomics in preoperative prediction of rectal cancer perineural invasion.

OBJECTIVES: Preoperative prediction of perineural invasion (PNI) in rectal cancer (RC) is challenging due to limited MRI resolution and the neglect of...

Generative artificial intelligence in clinical reasoning and differential diagnosis in internal medicine.

Clinical reasoning and differential diagnosis are core competencies in medicine. Large language models (LLMs) have generated considerable interest as ...

Heterodonty in the teeth of the turiasaurian sauropod from Angeac-Charente (Early Cretaceous, southwestern France): Comparison of anatomical and geometric morphometric approaches.

Sauropod teeth are often described within a taxonomic framework, with few studies focusing on heterodonty or intraspecific morphological variation. Th...

Integrative systems biology identifies PSMB2 as a core oxidative stress-associated target in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) represents one of the most aggressive and therapeutically challenging subtypes of breast cancer, characterized by...

Epidemiologically validated spatial modelling reveals fine-scale heat health risks.

Heat exposure drives substantial global disease and mortality burdens, making spatially explicit heat health risk assessment essential for targeted ad...

Computational methods, clinical evidence, and translational readiness for artificial intelligence for HER2 assessment using silver in situ hybridization (SISH).

Accurate determination of human epidermal growth factor receptor 2 (HER2) gene amplification is a cornerstone of precision oncology in breast cancer a...

BiGSTF-Net: inter-modal mutual guidance and intra-modal spatio-temporal fusion for EEG-fNIRS cognitive classification.

Objective.Electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) provide complementary temporal and spatial information for br...

[Artificial intelligence in the preparation of clinical expert opinions : Current evidence, use cases, and limitations in orthopedic assessment].

BACKGROUND: Generative AI, large language models, and ambient AI systems are rapidly being integrated into documentation-related processes in medicine...

The Eye as a Window to Cardio-Kidney-Metabolic Disease.

The Cardiovascular-Kidney-Metabolic (CKM) syndrome reframes cardiovascular, kidney, and metabolic disease as an integrated continuum, yet its manageme...

Artificial intelligence agents and agentic artificial intelligence applied to precision medicine.

Precision medicine seeks to individualise care by integrating multimodal biomedical data, yet most deployed clinical artificial intelligence (AI) rema...

Percutaneous thermal ablation for renal cell carcinoma: a comprehensive review of current evidence and future directions.

Thermal ablation (TA), including microwave ablation, radiofrequency ablation, and cryoablation, is increasingly used as a surgical alternative for T1a...

Microplastic quantification and chemical characterization in salt samples, using stereomicroscopy, smartphone camera and supervised machine learning tools.

The microplastic (MPs) pollution, especially in the oceans, has a direct impact on seafood products, particularly sea salt. This is a growing concern ...

Nephrology 2050: an evidence-informed roadmap from precision prevention to kidney regeneration.

BACKGROUND: Chronic kidney disease (CKD) is projected to become one of the leading causes of premature mortality worldwide by 2050. Simultaneously, ad...

Travelbee and relational AI: A triadic model for nursing.

BACKGROUND: Artificial intelligence (AI) in health care is typically evaluated on efficiency, predictive accuracy, and clinical decision support. Far ...