Alternative Medicine

Noninvasive prediction of occult pT3a upstaging in localized ccRCC with radiogenomic insights and prognostic relevance.

Occult pathological T3a (pT3a) upstaging in cT1b-T2a clear cell renal cell carcinoma (ccRCC) correlated with poor prognosis and necessitated modifications in surgical planning. However, predicting it preoperatively remains challenging. In this multicenter study involving 1661 patients across five institutions and the KiTS23 dataset, RENALNet, a 3D deep learning framework trained on nephrographic-p...

ChatGPT-4o Mini Fabricates and Miscites Evidence for American Academy of Orthopaedic Surgeons Hip Fracture Clinical Practice Guidelines.

BACKGROUND: Generative artificial intelligence (AI) large language model (LLM) chatbots, such as ChatGPT, are increasingly used to answer medical questions. This study sought to assess the accuracy and quality of evidence cited in ChatGPT-4o mini responses to questions pertaining to hip fracture care. METHODS: Prompt questions regarding hip fracture management that aligned with each of the 19 reco...

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors.

UNLABELLED: Cure rates for childhood malignancies using established therapy protocols have increased to an average of 80% but have reached a plateau. ...

Instance-level quantitative saliency in multiple sclerosis lesion segmentation.

In recent years, explainable methods for artificial intelligence (XAI) have tried to reveal and describe models' decision mechanisms in the case of cl...

Integrative LC-MS/MS, Bioinformatics, and Molecular Dynamics Reveal Multitarget Antioxidant Mechanisms of Bushen Huoxue Decoction in Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IVDD) is a major cause of low back pain and disability. Excessive reactive oxygen species (ROS) disrupt disc homeost...

MVICAD2: Multi-View Independent Component Analysis With Delays and Dilations.

Machine learning techniques in multi-view settings face significant challenges, particularly when integrating heterogeneous data, aligning feature spa...

Kilometer-scale convection-allowing model emulation using generative diffusion modeling.

Storm-scale convection-allowing models (CAMs) explicitly resolve convective dynamics within the atmosphere to predict the evolution of thunderstorms a...

Integrative transcriptomics, machine learning, and molecular docking reveal that nicotine exacerbates ischemic stroke: TLR4-dependent activation of NLRP3/caspase-1/GSDMD-mediated microglial pyroptosis.

OBJECTIVE: This study aimed to clarify the molecular mechanisms through which nicotine (Nic) aggravates ischemic stroke (IS), with an emphasis on infl...

Neuroimmune Cross-Talk and Multilevel Cascades in Fentanyl Toxicity: Interplay of Hypoxic Stress, Glial Activation, and Synaptic Dysregulation in Systems-Level Neurodegeneration.

Fentanyl, an ultra-potent synthetic opioid, has traditionally been characterized by its acute toxic effects, particularly respiratory depression. Howe...

Advances in the pharmacology and mechanism of anti-skin aging in Tonifying Traditional Chinese Medicines.

ETHNOPHARMACOLOGICAL RELEVANCE: According to the Traditional Chinese Medicine (TCM) tenet that "internal imbalances manifest externally," skin aging r...

Deciphering Multitarget Mechanisms of Phytochemical Flavonoids From Traditional Chinese Medicine: Emerging Insights Into Osteoporosis Therapeutics.

Osteoporosis is a common metabolic bone disorder characterized by reduced bone mass and compromised skeletal microstructure, increasing fracture risk....

Low-Frequency In-Plane Phonons Dominate Thermal Transport in Montmorillonite: Machine-Learning Molecular Dynamics Insights.

Montmorillonite (MMT), a foundational constituent of permafrost systems, plays a critical role in determining the thermophysical properties of frozen ...

Anti-angiogenesis effect of Baiying Juhua Decoction on the non-small cell lung cancer: integrating pharmacology, multi-machine learning and experimental investigation.

Baiying Juhua Decoction (BYJHD) is a well-established traditional Chinese herbal formula primarily composed of Solanum lyratum and chrysanthemum, whic...

Novel bayesian nonparametric unsupervised learning approach to precision symptom management in cancer survivors: a re-analysis of a comparative effectiveness trial.

Cancer survivors often experience multiple cooccurring symptoms such as insomnia, pain, fatigue, and anxiety; yet conventional analyses in symptom sci...

LeafAI: Interpretable plant disease detection for edge computing.

In real-world agriculture, healthy plant leaves are significantly more common than diseased ones. This natural class imbalance presents challenges in ...

Explainable Artificial Intelligence for the Mayo Endoscopic Score in Ulcerative Colitis.

INTRODUCTION: The Mayo endoscopic score (MES) is used widely in ulcerative colitis (UC) for severity assessment and therapeutic decision-making. Deep ...

Artificial Intelligence as an Assistant in Homeopathy.

Explainable depth-wise and channel-wise fusion models for multi-class skin lesion classification.

The clinical adoption of deep learning in dermatology requires models that are not only highly accurate but also transparent and trustworthy. To addre...

Integrative analysis identifies lactylation-related biomarkers in sepsis via bioinformatics and machine learning.

BACKGROUND: Protein lactylation is a novel post-translational modification driven by lactate and has emerged as a critical link between cellular metab...

Artificial intelligence for early diagnosis in emergency department.

In recent years, artificial intelligence (AI) has become an increasingly prominent player in emergency medicine, offering innovative tools to enhance ...