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Alternative Medicine

Latest AI and machine learning research in alternative medicine for healthcare professionals.

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Navigating the Multiverse: A Hitchhiker’s Guide to Selecting Harmonisation Methods for Multimodal Biomedical Data

The application of machine learning (ML) techniques in classification and prediction tasks has greatly advanced our comprehension of biological systems. There is a notable shift in the trend towards integration methods that specifically target the simultaneous analysis of multiple modes or types of data, showcasing superior results compared to individual analyses. Despite the availability of diver...

The impact of systematized generation, evaluation, and incorporation of machine learning algorithms for clinical variant classification

Variants of uncertain significance (VUS) pose a significant challenge for those undergoing genetic testing, leading to prolonged uncertainty and inappropriate medical care. VUS rate reduction is critical to fully realize the utility of genetic testing for all populations. With the growth of large-scale biological data sources and modern Machine Learning (ML) techniques, predictive modeling has eno...

AI-HOPE: An AI-Driven conversational agent for enhanced clinical and genomic data integration in precision medicine research

Introduction: The increasing complexity of clinical cancer research necessitates the development of automated tools capable of integrating clinical an...

AcuKG: a comprehensive knowledge graph for medical acupuncture

This study constructs an acupuncture knowledge graph (AcuKG) to systematically organize and represent acupuncture-related knowledge in a structured an...

Conversational AI Agent for Precision Oncology: AI-HOPE-WNT Integrates Clinical and Genomic Data to Investigate WNT Pathway Dysregulation in Colorectal Cancer

The WNT signaling pathway plays a critical role in colorectal cancer (CRC) initiation and progression, particularly in early-onset cases among underse...

Speaking the Language of Inclusion: Examining English Languages Requirements in Cardiovascular Digital Health Trials

Cardiovascular medicine is rapidly evolving, as it integrates digital technologies intended to decentralize care from the clinic and/or hospital setti...

Multi-Omics and AI-/ML-Driven Integration of Nutrition and Metabolism in Cancer: A Systematic Review, Meta-Analysis, and Translational Algorithm

Cancer is increasingly recognized as a metabolic disease with strong nutritional determinants. Recent advances in multi-omics technologies and artific...

Interpretable Deep Learning Approaches for Reliable GI Image Classification: A Study with the HyperKvasir Dataset

Deep learning has emerged as a promising tool for automating gastrointestinal (GI) disease diagnosis. However, multi-class GI disease classification r...

Assessing the feasibility and acceptability of a bespoke large language model pipeline to extract data from different study designs for public health evidence reviews

Data extraction is a critical but resource-intensive step of the evidence review process. Whilst there is evidence that artificial intelligence (AI) a...

Experimental investigation of muscle-tendon unit geometry and kinematics in lower-limb muscles during gait: Current Applications and Future Directions – A Scoping Review

Musculoskeletal (MSK) modeling and ultrasound imaging (USI) are complementary techniques that, when combined with three-dimensional gait analysis (3DG...

Introducing Answered with Evidence - a framework for evaluating whether LLM responses to biomedical questions are founded in evidence

The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their ...

Artificial Intelligence Models for Predicting Molecular Pathway Activity in Spinal Cord Injury: A Systematic Review

Spinal cord injury (SCI) remains a devastating neurological condition with high global incidence and minimal curative options. The pathobiology is mul...

Childhood Maltreatment and Risk for Illicit Substance Use: Evidence for Mid-Adolescence as a Sensitive Exposure Period

Childhood maltreatment is a well-established risk factor for substance misuse. However, it remains unclear whether risk for specific illicit substance...

BASIC: Bayesian Spiral Attention Classifier for Interpretable Medical Image Classification

Accurate medical image classification is critical for early diagnosis and effective treatment planning. However, conventional deep learning models oft...

Artificial Intelligence Reveals Prognostic TP53 Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer Among Populations at Risk

The incidence of early-onset colorectal cancer (EOCRC; <50 years) continues to rise, with the most rapid increases observed among Hispanic/Latino (H/L...

EAGLE-AI: A large language model workflow for automated extraction and scoring of literature evidence linking genes to autism spectrum disorder

We previously developed the Evaluation of Autism Gene Link Evidence (EAGLE) manual curation framework and used it to characterise 219 autism-associate...

Machine Learning-Driven Assessment of Early Graft Function in Living Donor Kidney Transplantation Using Intraoperative Laser Speckle Contrast Imaging

Although living donor kidney transplantation (LDKT) generally achieves excellent outcomes, 5–12% of recipients experience early graft dysfunction, whi...

A statistical framework for evaluating the repeatability and reproducibility of large language models

A major concern in applying large language models (LLMs) to medicine is their reliability. Because LLMs generate text by sampling the next token (or w...

Science or Advocacy? The Global Rise of Policy Claims in Population Health Research (1990-2024)

Should original research routinely contain prominent policy claims, such as recommendations for policymakers or broad calls to action? Growing emphasi...

Integrated Genetic, Molecular, and Wearable Sensor Biomarkers Enable Bayesian Machine Learning-Driven Precision Stratification in Parkinson’s Disease: A Comprehensive Multi-Cohort Validation Study

We present a Bayesian machine learning framework integrating genetic, molecular, and wearable sensor biomarkers for precision medicine in Parkinson’s ...

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