Geriatrics

Alzheimer's Disease

Latest AI and machine learning research in alzheimer's disease for healthcare professionals.

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Geriatrics Subcategories: Alzheimer's Disease Medicare
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The Blind Spot in 2D Infants' Pose Estimation:Robust Learning from Noisy Annotations

Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely...

ECG-based longitudinal risk prediction across diseases and organ systems

Artificial intelligence applied to routine electrocardiograms (ECGs) has largely focused on detectin...

A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid

Background: The Centiloid (CL) scale standardizes global amyloid PET quantification and is widely us...

GraM-Diff: A Unified Graph-Mamba Diffusion Framework for EEG-Based Alzheimer's Disease Data Generation and Diagnosis

Electroencephalography (EEG) is a promising, non-invasive, and cost-effective modality for Alzheimer...

Under-Mattress Temporal Sensing for Next-Day Agitation Risk Scoring in Dementia Wards

Agitation fluctuates over short time horizons in people living with dementia, yet continuous physiol...

Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

Individuals with Down syndrome (DS) display developmental delay, intellectual disability, premature ...

Differential Associations of Microglial Inflammation on LATE-NC and Tangle-Related Hippocampal Atrophy

BACKGROUND: Accumulations of AD and LATE-NC both contribute to changes in hippocampal volume, possib...

Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease

Biological heterogeneity in Alzheimer's Disease (AD) poses a critical diagnostic challenge, particul...

Explainable Deep Learning Reveals Distributed Neurodegeneration Signatures of Neuropsychiatric Symptoms Across the Alzheimer's Continuum

Neuropsychiatric symptoms (NPS) are increasingly recognized as critical components of the disease pr...

Integrating cognitive, linguistic and acoustic features to identify individuals with cognitive impairment: a proof-of-concept study

Early identification of cognitive impairment remains challenging in settings where comprehensive cog...

Behind the [MASK]: Disentangling Representation and Faithfulness in DAPF-Based Dementia Detection

Spoken-language analysis via prompt-based domain-adaptive models is a promising direction for low-re...

Cell type-resolved chromatin accessibility clocks for brain aging

Aging is a progressive decline in biological function that is proposed to be driven by the accumulat...

Spoken Recall Reveals Lexical and Mnemonic Function Differences in Temporal Lobe Epilepsy Patients

Background and Objectives: Word-finding difficulty is common in healthy aging and in neurologic diso...

MatReplace: A Reference-Free, Conditioning-Aligned Benchmark for Material Replacement in Interior Scenes

Material replacement is a common interior-design operation: changing the material of a selected surf...

Mapping Alzheimer's neuropathology signatures to the whole brain transcriptome using machine learning data fusion

In Alzheimer's disease (AD), misfolded proteins emerge across the entire brain in structured, yet no...

Reliability and disease sensitivity are dissociable properties of EEG foundation-model representations

Abstract EEG foundation models (EEG-FMs) are evaluated almost entirely on disease-discrimination acc...

Calibration-Aware and Interpretable Graph Learning for Multi-Cohort Diffusion Connectome Brain-Age Modeling

Brain-age models derived from diffusion MRI-based structural connectomes may provide imaging biomark...

Spending Scarce Confirmatory PET Measurements: Target-Aligned Validation in A4/LEARN

Anti-amyloid therapies and blood-based biomarkers are changing Alzheimer disease workups into a two-...

Predicting Subjective Cognitive Decline on Future BRFSS Survey Years: An Open Multi-Language Machine Learning Benchmark

Background and Objectives: Subjective cognitive decline (SCD), self-reported worsening confusion or ...

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