Alzheimer's Disease

Multi-knowledge informed deep learning model for multi-point prediction of Alzheimer's disease progression.

The diagnosis of Alzheimer's disease (AD) based on visual features-informed by clinical knowledge has achieved excellent results. Our study endeavors to present an innovative and detailed deep learning framework designed to accurately predict the progression of Alzheimer's disease. We propose Mul-KMPP, a Multi-Knowledge Informed Deep Learning Model for Multi-Point Prediction of AD progression, int...

Integrating neuroscience and artificial intelligence: EEG analysis using ensemble learning for diagnosis Alzheimer's disease and frontotemporal dementia.

BACKGROUND: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are both progressive neurological disorders that affect the elderly. Distinguishing between individuals suffering from these two diseases in the early stages can be quite challenging, and due to their different treatments, it has become an important problem. Machine learning (ML) algorithms can be helpful in this matter due to ...

Identification of therapeutic targets for Alzheimer's Disease Treatment using bioinformatics and machine learning.

Alzheimer's disease (AD) is a complex neurodegenerative disorder that currently lacks effective treatment options. This study aimed to identify potent...

UK Biobank MRI data can power the development of generalizable brain clocks: A study of standard ML/DL methodologies and performance analysis on external databases.

In this study, we present a comprehensive pipeline to train and compare a broad spectrum of machine learning and deep learning brain clocks, integrati...

Using Machine Learning to Design a FeMOF Bidirectional Regulator for Electrochemiluminescence Sensing of Tau Protein.

The single-luminophore-based ratiometric electrochemiluminescence (ECL) sensor coupling bidirectional regulator has become a research hotspot in the d...

Predicting conversion in cognitively normal and mild cognitive impairment individuals with machine learning: Is the CSF status still relevant?

INTRODUCTION: Machine learning (ML) helps diagnose the mild cognitive impairment-Alzheimer's disease (MCI-AD) spectrum. However, ML is fed with data u...

Deep Learning-Based Precontrast CT Parcellation for MRI-Free Brain Amyloid PET Quantification.

PURPOSE: This study aimed to develop a deep learning (DL) model for brain region parcellation using CT data from PET/CT scans to enable accurate amylo...

Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.

BACKGROUND: Alzheimer's disease (AD), a hallmark of age-related cognitive decline, is defined by its unique neuropathology. Metabolic dysregulation, p...

Preclinical Cognitive Markers of Alzheimer Disease and Early Diagnosis Using Virtual Reality and Artificial Intelligence: Literature Review.

BACKGROUND: This review explores the potential of virtual reality (VR) and artificial intelligence (AI) to identify preclinical cognitive markers of A...

An unsupervised learning approach for clustering joint trajectories of Alzheimer's disease biomarkers: An application to ADNI Data.

INTRODUCTION: Current models of Alzheimer's disease (AD) progression assume a common pattern and pathology, oversimplifying the heterogeneity of clini...

Natural language processing-based classification of early Alzheimer's disease from connected speech.

INTRODUCTION: The automated analysis of connected speech using natural language processing (NLP) emerges as a possible biomarker for Alzheimer's disea...

Alzheimer's Disease: Exploring Pathophysiological Hypotheses and the Role of Machine Learning in Drug Discovery.

Alzheimer's disease (AD) is a major neurodegenerative dementia, with its complex pathophysiology challenging current treatments. Recent advancements h...

Enhanced detection of mild cognitive impairment in Alzheimer's disease: a hybrid model integrating dual biomarkers and advanced machine learning.

Alzheimer's disease (AD) is a complex, progressive, and irreversible neurodegenerative disorder marked by cognitive decline and memory loss. Early dia...

"Tom and Pepper Lab". Robotics for cognitive stimulation and social skills: A preliminary study.

Dementia affects over 55 million people globally, with early cognitive decline, such as Mild Cognitive Impairment (MCI), often preceding neurodegenera...

Multimodal multiview bilinear graph convolutional network for mild cognitive impairment diagnosis.

Mild cognitive impairment (MCI) is a significant predictor of the early progression of Alzheimer's disease (AD) and can serve as an important indicato...

Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer's disease: insights from machine learning analyses and WGCNA.

BACKGROUND: The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear.

Automated karyogram analysis for early detection of genetic and neurodegenerative disorders: a hybrid machine learning approach.

Anomalous chromosomes are the cause of genetic diseases such as cancer, Alzheimer's, Parkinson's, epilepsy, and autism. Karyotype analysis is the stan...

Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia.

Existing dementia prediction models using non-neuroimaging clinical measures have been limited in their ability to identify disease. This study used m...

Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospective observational study.

BACKGROUND: Intracerebral amyloid β (Aβ) accumulation is considered the initial observable event in the pathological process of Alzheimer's disease (A...

Sulfonic acid functionalized β-amyloid peptide aggregation inhibitors and antioxidant agents for the treatment of Alzheimer's disease: Combining machine learning, computational, in vitro and in vivo approaches.

Alzheimer's disease (AD) is characterized as a neurodegenerative disorder that is caused by plaque formation by accumulating β-amyloid (Aβ), leading t...