Anxiety & Stress

Curcumin reprograms metabolic pathways and MAPK signaling to exert antidepressant effects.

BACKGROUND: Depression is a prevalent and debilitating mental disorder with limited treatment options. Curcumin, a natural compound with neuroprotective and anti-inflammatory properties, has shown potential antidepressant effects, though the underlying mechanisms remain incompletely understood. METHODS AND RESULTS: In this study, we investigated the therapeutic effects and molecular mechanisms of ...

CT-free attenuation correction of 13N-ammonia cardiac PET images using conditional denoising diffusion implicit model with logarithmic linear normalization.

BACKGROUND AND OBJECTIVE: CT-based attenuation correction (CT-AC) is commonly used in cardiac PET but introduces additional radiation exposure, which is particularly problematic for pediatrics or repeat scans. This study aims to generate attenuation-corrected cardiac PET images from non-attenuation-corrected (NAC) PET input without CT using a conditional denoising diffusion implicit model (cDDIM)....

Delineating white matter phenotypes of sensori-/psychomotor functioning in large-scale cohorts of healthy individuals and patients with mental disorders across the lifespan (whiteSPAN): rationale and methods of an interdisciplinary bicentric project.

Aberrant sensori-/psychomotor functioning-including muscular hand weakness, sedentary behavior, psychomotor agitation, slowing, agitation, apathy, and...

Dynamic frame-by-frame motion correction for 18F-flurpiridaz PET-MPI using convolution neural network.

PURPOSE: Precise quantification of myocardial blood flow (MBF) and flow reserve (MFR) in 18F-flurpiridaz PET significantly relies on motion correction...

Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry.

AIMS/HYPOTHESIS: Available methods for predicting the onset and progression of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) are n...

Deep learning-based obstructive coronary artery disease prediction from myocardial perfusion SPECT.

PURPOSE: We aim to apply the deep learning (DL) technique to predict the gold-standard invasive coronary angiography (ICA) for coronary artery disease...

Targeted inhibition of colorectal cancer by nano-dihydroartemisinin liposomes: Insights into the disruption of ABCG2 and BCL2 leading to induction of oxidative stress and metabolic disorder.

PURPOSE: Colorectal cancer is an aggressive malignancy characterized by significant drug resistance and a complex tumor microenvironment. Nano-dihydro...

Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders.

Biomarker research in psychopathology increasingly employs high-dimensional Omics approaches. Yet, proteomics based on human hair remain largely unexp...

Anxiety Promotes Occlusal Interference-Induced Myalgia via the Mesolimbic System.

Acute occlusal interference may induce chronic masticatory myalgia in some individuals. The potential factors and underlying mechanisms that predispos...

Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.

As humans embark on longer and deeper missions into space, it is crucial to understand how spaceflight impacts the immune system. Decades of discoveri...

Neurophysiological mechanisms and predictive modeling of SSRI treatment response in depression disorder based on multidimensional EEG features.

BACKGROUND: Depression exhibits significant heterogeneity in antidepressant treatment response. This study aimed to develop an Electroencephalography ...

Sleep disturbance recorded via wearable sensors predicts depression severity 9 years later.

BACKGROUND: Major depressive disorder (MDD) is prevalent and poses major public health implications. Autonomic nervous system (ANS) dysregulation and ...

Blood urea nitrogen-to-lipid ratios are novel indices inversely associated with anxiety: Insights from NHANES.

BACKGROUND: Anxiety is a highly prevalent mental disorder linked to metabolic and renal dysregulation. Blood urea nitrogen (BUN) and lipid profiles ha...

Cingulate atrophy as a shared structural basis for cognitive and functional brain impairments in GAD, PD, and OCD: Links to shared gene expression and treatment implications.

BACKGROUND: Structural brain deficits associated with generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD)...

Brain dynamics and depressive symptoms in young adults: Evidence from EEG.

BACKGROUND: Depression is a major public health concern, with a rising prevalence among adolescents and young adults. However, the neural mechanisms u...

Comorbid anxiety predicts lower odds of MDD improvement in a trial of smartphone-delivered interventions.

Comorbid anxiety disorders are common among patients with major depressive disorder (MDD), but their impact on outcomes of digital and smartphone-deli...

Using Machine Learning and SHAP to Identify Biomechanical Risk Factors for Increased Achilles Tendon Stress during Low-Temperature Running.

PURPOSE: Achilles tendon injuries are common during running in low-temperature environments, but the underlying biomechanical mechanisms remain unclea...

Anesthesia and mitochondria: balancing toxicity and protection through emerging therapeutic strategies.

Anesthesia is a cornerstone of modern surgical practice, enabling interventions by deliberately modulating nociception and consciousness-from localize...

Radiation Risk in 2D Mammography Screening: A Scoping Review of Modelling Strategies and Emerging AI Applications.

Breast cancer is the most commonly diagnosed cancer among women worldwide, and concerns regarding radiation exposure from mammography screening remain...

Prefrontal cortex cytosolic and synaptosome proteome reveal molecular signatures of resilience to chronic social isolation stress in rats.

Chronic social isolation stress (CSIS) is a well-established preclinical model for studying stress-induced neurobiological changes and their effects o...