Anxiety & Stress

Structural alterations related to emotion dysregulation, anxiety and self-harm in adolescents borderline personality disorder. A source-based morphometry study.

OBJECTIVE: Previous research suggests that adolescents with BPD (aBPD) exhibit distinct neuroanatomical alterations, although methodological limitations such as low sample size, and the reliance on univariate massive statistical analyses, prevent conclusions. Moreover, the possibility to associate these abnormalities with clinical features has been only partially explored. This study aims to inves...

Estimating the effect of reducing average annual ambient PM2.5 concentrations on allostatic load in children.

OBJECTIVE: Chronic exposure to environmental stressors may result in dysregulation across the body's adaptive stress-response systems, which can be conceptualized as allostatic load (AL). We estimated the effect of reducing annual average ambient fine particulate matter (PM2.5) on AL in children. METHODS: Cross-sectional data were collected from 279 participants, 1-12 years old. Recruitment occurr...

Artificial Intelligence Attack-Resilient Physical Unclonable Functions from Colloidal Nanowire Randomness.

Countless tiny needles scatter across a surface, each landing in a unique, unpredictable pattern. This principle is extended to the microscale by util...

Who engages? Machine learning insights into digital mindfulness-based intervention for generalized anxiety disorder.

BACKGROUND: Although mindfulness ecological momentary interventions (MEMI) appear effective in alleviating worry symptoms, treatment engagement remain...

Differential factor effects in comorbid depressive and anxiety symptoms (CDAS): A machine learning approach to individualized mental health promotion.

BACKGROUND: Depression and anxiety comorbid presents greater severity than isolated symptoms. Traditional analyses often fail to capture complex inter...

An explainable predictive machine learning model reveals ARRB2 as a key gene in post-traumatic stress disorder: A GEO database study.

A number of processes and pathways have been reported in the development of Post-Traumatic Stress Disorder (PTSD), however, novel biomarkers need to b...

Leveraging low-cost app-based step count data to assess depression and anxiety in university students: A cross-sectional mobile health study.

BACKGROUND: The prevalence of depression and anxiety among college students worldwide is on the rise, significantly impacting their health and quality...

Integrative bioinformatics analysis reveals that microplastics promote chronic rhinosinusitis with nasal polyps through NOXO1-mediated oxidative stress and myoepithelial cell reprogramming.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory disease whose environmental pathogenic factors remain unclear. Microplasti...

Water stress evolution and redistribution pathways under global inequality in consumption.

Global water stress is intensifying alongside the expansion of goods and services consumption. Based on consumption-based water footprint (CWF) accoun...

Developing and Validating a Prediction Model for the Severe Pain-Fatigue-Sleep Disturbance Symptom Cluster in Patients with Lung Cancer Following Chemotherapy: A Machine Learning Analysis.

OBJECTIVES: Pain-fatigue-sleep disturbance symptom (PFS) cluster is the most common symptom cluster in patients with lung cancer following chemotherap...

Precision engineering of anti-atherosclerotic herbal nanomedicine: from machine learning-aided active components screening to optimized metal-phenolic network codelivery.

Atherosclerosis (AS), a chronic inflammatory disease linked to oxidative stress and lipid imbalance, remains a major cardiovascular threat. Traditiona...

Curcumin reprograms metabolic pathways and MAPK signaling to exert antidepressant effects.

BACKGROUND: Depression is a prevalent and debilitating mental disorder with limited treatment options. Curcumin, a natural compound with neuroprotecti...

CT-free attenuation correction of 13N-ammonia cardiac PET images using conditional denoising diffusion implicit model with logarithmic linear normalization.

BACKGROUND AND OBJECTIVE: CT-based attenuation correction (CT-AC) is commonly used in cardiac PET but introduces additional radiation exposure, which ...

Delineating white matter phenotypes of sensori-/psychomotor functioning in large-scale cohorts of healthy individuals and patients with mental disorders across the lifespan (whiteSPAN): rationale and methods of an interdisciplinary bicentric project.

Aberrant sensori-/psychomotor functioning-including muscular hand weakness, sedentary behavior, psychomotor agitation, slowing, agitation, apathy, and...

Dynamic frame-by-frame motion correction for 18F-flurpiridaz PET-MPI using convolution neural network.

PURPOSE: Precise quantification of myocardial blood flow (MBF) and flow reserve (MFR) in 18F-flurpiridaz PET significantly relies on motion correction...

Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry.

AIMS/HYPOTHESIS: Available methods for predicting the onset and progression of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) are n...

Deep learning-based obstructive coronary artery disease prediction from myocardial perfusion SPECT.

PURPOSE: We aim to apply the deep learning (DL) technique to predict the gold-standard invasive coronary angiography (ICA) for coronary artery disease...

Targeted inhibition of colorectal cancer by nano-dihydroartemisinin liposomes: Insights into the disruption of ABCG2 and BCL2 leading to induction of oxidative stress and metabolic disorder.

PURPOSE: Colorectal cancer is an aggressive malignancy characterized by significant drug resistance and a complex tumor microenvironment. Nano-dihydro...

Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders.

Biomarker research in psychopathology increasingly employs high-dimensional Omics approaches. Yet, proteomics based on human hair remain largely unexp...

Anxiety Promotes Occlusal Interference-Induced Myalgia via the Mesolimbic System.

Acute occlusal interference may induce chronic masticatory myalgia in some individuals. The potential factors and underlying mechanisms that predispos...