Anxiety & Stress

Neurophysiological mechanisms and predictive modeling of SSRI treatment response in depression disorder based on multidimensional EEG features.

BACKGROUND: Depression exhibits significant heterogeneity in antidepressant treatment response. This study aimed to develop an Electroencephalography (EEG)-based machine learning model integrating multidimensional features to predict selective serotonin reuptake inhibitors (SSRI) efficacy and elucidate neurophysiological mechanisms. METHODS: Resting-state EEG data were recorded from 27 patients di...

Sleep disturbance recorded via wearable sensors predicts depression severity 9 years later.

BACKGROUND: Major depressive disorder (MDD) is prevalent and poses major public health implications. Autonomic nervous system (ANS) dysregulation and sleep disturbances are theorized to be distal risk factors. However, previous research has depended on cross-sectional designs, small predictor sets, and suboptimal methods, limiting temporal inference and predictive accuracy. We thus capitalized on ...

Blood urea nitrogen-to-lipid ratios are novel indices inversely associated with anxiety: Insights from NHANES.

BACKGROUND: Anxiety is a highly prevalent mental disorder linked to metabolic and renal dysregulation. Blood urea nitrogen (BUN) and lipid profiles ha...

Cingulate atrophy as a shared structural basis for cognitive and functional brain impairments in GAD, PD, and OCD: Links to shared gene expression and treatment implications.

BACKGROUND: Structural brain deficits associated with generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD)...

Brain dynamics and depressive symptoms in young adults: Evidence from EEG.

BACKGROUND: Depression is a major public health concern, with a rising prevalence among adolescents and young adults. However, the neural mechanisms u...

Comorbid anxiety predicts lower odds of MDD improvement in a trial of smartphone-delivered interventions.

Comorbid anxiety disorders are common among patients with major depressive disorder (MDD), but their impact on outcomes of digital and smartphone-deli...

Using Machine Learning and SHAP to Identify Biomechanical Risk Factors for Increased Achilles Tendon Stress during Low-Temperature Running.

PURPOSE: Achilles tendon injuries are common during running in low-temperature environments, but the underlying biomechanical mechanisms remain unclea...

Radiation Risk in 2D Mammography Screening: A Scoping Review of Modelling Strategies and Emerging AI Applications.

Breast cancer is the most commonly diagnosed cancer among women worldwide, and concerns regarding radiation exposure from mammography screening remain...

Prefrontal cortex cytosolic and synaptosome proteome reveal molecular signatures of resilience to chronic social isolation stress in rats.

Chronic social isolation stress (CSIS) is a well-established preclinical model for studying stress-induced neurobiological changes and their effects o...

Quality control of entomopathogenic nematodes through infrared spectroscopy (FTIR-ATR, 2D-COS): Tracing, modelling and prediction.

Entomopathogenic nematodes (EPNs) are widely used in biological pest control, yet their efficacy in field applications is highly dependent on physiolo...

Assessing the influence of generative artificial intelligence (GenAI) on awareness and behavior in medical research integrity: An online survey study.

BACKGROUND: Generative Artificial Intelligence(GenAI) significantly enhances medical research efficiency but raises ethical concerns regarding researc...

Research experience and career factors in relation to mental health problems: Prevalence, risk factors, and machine learning-based predictive estimates.

BACKGROUND: Mental health issues, including depression, anxiety, and insomnia, are increasingly prevalent among university students and graduates, esp...

Can the mind perception of perceived artificial intelligence-generated content alleviate involution anxiety? A longitudinal study with social support as a mediator.

Involution anxiety, characterized by heightened stress and competition in educational and professional settings, is a significant psychological trait ...

AI fragment based optimization of saffron and chamomile phytochemicals as aryl hydrocarbon receptor inhibitors for dementia therapy an integrated computational approach.

Dementia represents a rapidly rising global health challenge as a progressive neurodegenerative disease with few options for disease-modifyingtreatmen...

Integrating molecular generation and fingerprints transferring for single-molecule theranostics targeting endoplasmic reticulum stress.

INTRODUCTION: Precise diagnosis and treatment of diseases necessitate quantitative visualization and modulation of subcellular structures. The endopla...

Beyond Adverse Childhood Experiences: What Should be Considered for Trauma-Focused Adolescent Mental Health Risk Assessments?

To align with emerging policies for adolescents, feasible, accurate, and equitable trauma-focused assessment protocols need to be developed. To date, ...

Predictive Modeling of Comorbid Depression and Anxiety Symptoms Among Prospective University Students: A GIS-Based and Machine Learning Study.

Prospective university students are highly susceptible to mental health issues such as depression and anxiety. This study investigates the prevalence ...

Screening and investigating the regulatory mechanisms of oxidative stress-related biomarkers in thoracic aortic aneurysms.

Excess reactive oxygen species leading to oxidative stress has been identified as a significant factor in cardiovascular disease. However, the molecul...

PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders.

INTRODUCTION: Cognitive behavioural therapy (CBT) serves as a first-line treatment for internalising disorders (ID), encompassing depressive, anxiety ...

Gut microbiota composition is related to anxiety and aggression scores in companion dogs.

There is mounting evidence for a link between behaviour and the gut microbiome in animal and human health. However, the role of the gut microbiome in ...