Anxiety & Stress

DINCH induces intestinal toxicity through "ROS-ENO1-PA-lipid peroxidation" axis: An integrated approach combining network toxicology and experimental validation.

Cyclohexane-1,2-dicarboxylic acid diisononyl ester (DINCH), as a "green" alternative to phthalates, has been widely used in consumer products and industrial materials. Consequently, its environmental and human exposure levels continue to rise, necessitating a systematic evaluation of its mechanism of intestinal toxicity. This study developed a strategy integrating "network toxicology-machine learn...

Transcription Factors Regulating Nutrient and Ion Uptake in Plants Exposed to Abiotic and Biotic Stress Conditions.

Plant growth and productivity are severely constrained by abiotic and biotic stresses, which disrupt essential physiological processes, particularly nutrient and ion homeostasis. In response to these challenges, plants activate sophisticated molecular networks, with transcription factors (TFs) emerging as central regulators that integrate stress signals with nutrient management. This review synthe...

High-content imaging driven algal phenotypes enable precise multilevel discrimination of heavy metal stress.

Conventional water quality monitoring based on fixed chemical thresholds often fails to capture the integrated biological effects of pollutant mixture...

Shear Stress Modeling and Machine Learning for Nanomedicine Development: A Mechanistic Pathway to Pharmacokinetic Prediction.

Clinical translation of nanomedicines remains constrained by a persistent gap between static preclinical assays and the dynamic shear environment of t...

miR-124 Ameliorates Spatial Memory Deficits in Rats Exposed to Single-Prolonged Stress by Downregulating IQGAP1 to Regulate Actin-Binding Proteins and Apoptosis in Hippocampal Neurons.

Post-traumatic stress disorder (PTSD) is a highly prevalent, trauma-induced psychiatric condition characterized by persistent cognitive-affective dysf...

DINCH Exposure Contributes to Osteoarthritis Pathogenesis via TSPO-Mediated Chondrotoxicity: Evidence from In Silico Prediction to Experimental Validation.

Diisononyl cyclohexane-1,2-dicarboxylate (DINCH), a widely used plasticizer substitute, has been widely detected in human populations and has emerged ...

Perceived control influences users' acceptance of AI-enabled services.

With the rapid diffusion of artificial intelligence (AI) in the service sector, users' acceptance of AI-enabled services has become an important issue...

Image-based trait extraction of Chenopodium quinoa grown under salinity and drought stress.

Above ground crop traits provide an early indication of a plant's capacity to tolerate stress, and are important for breeding programs aimed at improv...

Robust stress detection from wearable ECG using subject-specific normalization and stacking ensemble learning.

Driven by the rising prevalence of mental health issues, this study proposes an automated stress monitoring system using wearable ECG signals. Designe...

A hybrid CNN-machine learning model for anxiety screening with mandala coloring patterns: Feature extraction and classification performance.

Traditional anxiety assessments typically rely on self-report questionnaires and often emphasize somatic symptoms, potentially overlooking nuanced beh...

AI awareness, AI fear of missing out, and work demotivation as pathways to occupational strain in Vietnamese hospitality employees.

Artificial intelligence (AI) is reshaping hospitality work and changing how employees perceive occupational risks and their capacity to adapt. How the...

Large Language Model Few-Shot Learning for Predicting Individual Treatment Response to Smartphone-Based Mindfulness in Autistic Adults With Anxiety: Secondary Analysis of a Randomized Controlled Trial.

BACKGROUND: Anxiety disorders are highly prevalent among adults with autism, with 20%-65% experiencing at least one diagnosable anxiety disorder. Whil...

Non-coding RNAs as central regulators of phytohormone signaling in plant abiotic stress responses.

Plants are continuously exposed to a wide range of abiotic stresses, including drought, salinity, temperature extremes, nutrient deficiency, and heavy...

Identification and validation of an explainable screening model of college students' mental health with therapeutic strategy implications.

Mental health issues, especially depressive symptoms, among young adults represent a public health challenge. Conventional psychological assessment to...

Neural network-enhanced investigation of ferroptosis and druggability in early-onset alzheimer's disease.

Alzheimer's disease (AD) is a complex neurodegenerative disorder which is multifactorial in nature. Some of its characteristics are slow cognitive dec...

Three-Level cascading defense mechanism of silicon-based materials for mitigating heavy metals stress in crops.

Silicon-based materials (SBMs) are widely used to alleviate heavy metals (HMs) stress in crops, yet their integrated effects on soil-plants systems re...

Temporal Germination of Lettuce under Salinity and Nano-Silicon: A High-Throughput Phenomics Framework with Deep Learning.

Accurate high-throughput evaluation of seed germination under abiotic stress is often hindered by subjective manual scoring and insufficient temporal ...

The mediating effect of self-efficacy on the relationship between digital literacy and artificial intelligence anxiety in nursing students.

OBJECTIVE: The integration of digital technologies and artificial intelligence (AI) into healthcare has transformed nursing education, while also rais...

Model Development and Feasibility of Real-World Deployment of Multimodal Input-Based Subtyping of Depression in Tele-Counseling for Scalable Mental Health Assessment.

The rapid growth of tele-counseling and the use of lay counselors in high-volume, low-resource mental health services has created a need for scalable ...

Convergent genomic trajectories shape adaptation to life on land across animal lineages.

How animals repeatedly adapted to life on land is a central question in evolutionary biology. While terrestrialisation occurred independently across a...