Anxiety & Stress

Cumulative microscopy reveals cellular states in fibroblasts from patients with genetic disorders

Analysis of cellular states and signaling trajectories can provide insights into causes of disease. We developed cumulative microscopy, a method to perform cyclical imaging without elution or quenching steps. Cumulative microscopy computationally extracts individual signals from accumulating fluorescence during sequential imaging. We used cumulative microscopy to quantitatively assess cell cycle a...

Interpretable Machine Learning on Soybean Multi Omics Data Reveals Drought-Driven Shifts of Plant-Microbe Interactions

Plant-microbe interactions in the rhizosphere are central to plant growth, nutrient acquisition, and stress resilience. Multi-omics approaches enable comprehensive profiling of different biological layers, yet integrating these data to understand the mechanisms underlying plant-microbe symbiosis, particularly under drought stress, remains a major challenge. We integrated genomic, metabolomic, and ...

Linking brain structure to stress reactivity: Cingulate surface area predicts acute cortisol responses

Altered stress responses are closely linked to mental disorders, but the role of brain structure in acute cortisol responses to psychosocial stress re...

From model to field: predictive design of microbial communities for resilient crop performance

Synthetic microbial communities (SynComs) represent a promising approach to enhance crop growth and stress resilience through microbiome engineering. ...

Predictive models of the genetic bases underlying budding yeast fitness in multiple environments

The ability of organisms to adapt and survive depends on the effects of genes and the environment on fitness. However, the multigenic nature of fitnes...

Independent genomic trajectories shape adaptation to life on land across animal lineages

How animals repeatedly adapted to life on land is a central question in evolutionary biology. While terrestrialisation occurred independently across a...

Machine Learning Ensemble Reveals Age-Specific Responses of Murine Mammary Tissue to Spaceflight With Relevance to Breast Cancer: An Observational Study

Spaceflight presents unique environmental stressors, such as microgravity and radiation, that significantly affect biological systems at the molecular...

Deep Learning of Brain-Behavior Dimensions Identifies Transdiagnostic Biotypes in Youth with ADHD and Anxiety Disorders

Attention-deficit/hyperactivity disorder and anxiety disorders are highly prevalent in youth and are characterized by substantial heterogeneity and fr...

Decoding pathogen ecological memory from chemical-stress phenotypes

Can standardized chemical stress reveal an ecological “memory” of host origin in plant pathogens? We profiled six coffee-associated Colletotrichum iso...

A memory-driven reinforcement learning model of phenotypic adaptation for anticipating therapeutic resistance in prostate cancer

While contemporary cancer treatment strategies have significantly prolonged the lives of patients, therapeutic resistance remains a predominant cause ...

Machine Learning-Driven Discovery of Synergistic Protein Interactions Identifies ATL3 as a Putative Biomarker for Cancer Drug Response

Resistance to targeted molecular therapies—both primary and acquired—remains a major obstacle to effective cancer treatment. Despite extensive researc...

Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line t...

Global Analysis of Aggregation Determinants in Small Protein Domains

Protein aggregation is an obstacle for engineering effective recombinant proteins for biotechnology and therapeutic applications. Predicting protein a...

Electrophysiological monitoring of plants: an exploratory study on drought stress

Climate change is increasing environmental stress, particularly rising temperatures and water scarcity, in both natural and human-managed systems such...

Flexible brain state engagement predicts cognitive control transdiagnostically

Cognitive control supports adaptive responses in an ever-changing world. While alterations in cognitive control have been consistently observed in a r...

Environmental Conflict Modulates Pavlovian Bias

Pavlovian avoidance enables rapid defensive responding but can undermine goal-directed behaviour when it overrides instrumental control, a tendency am...

Social isolation upregulates takeout expression in female Drosophila melanogaster to promote sucrose feeding

Drosophila melanogaster provides a model system to examine how environmental stress interacts with sex to induce changes in brain function and behavio...

Differential Cerebral White Matter Tract Alterations in Generalized Anxiety Disorder Revealed by Ultra-High Field 7T Diffusion-Weighted Imaging

Generalized anxiety disorder (GAD) is characterized by chronic worry and emotional dysregulation, yet its underlying white matter (WM) architecture re...

Airborne Nanoplastics Perturb Mitochondrial Complex I via the ND6 Axis: Polymer-Specific Mitoepigenetic Remodeling Integrating Experimental, In Silico, and Machine Learning Analyses

Airborne nanoplastics constitute an emerging class of environmental contaminants, but their mitoepigenetic effects on human immune cells have not been...

A Context-Specific, Literature-Supported Framework for Validating Stress Response Models in Mammals

Computational models of stress responses can highlight candidate genes underlying physiological adaptation, but their utility depends on rigorous vali...