Arthritis

Bioinformatic identification of THY1 as a target in osteoarthritis and its effects on chondrocyte senescence and apoptosis.

Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide and imposes a substantial public health burden due to the lack of effective disease-modifying drugs. Exosome-related genes participate in exosome biogenesis, cargo sorting, and secretion, serving as critical regulatory elements in exosome-mediated intercellular communication. However, their systematic characterization i...

Radiolabeled drug-delivery and controlled-release nanocarriers for arthritis: Clinical evidence, kinetic modeling, radiation-safety challenges, and precision nanotheranostics.

BACKGROUND: Arthritis comprises a heterogeneous group of inflammatory and degenerative joint disorders characterized by distinct pathological mechanisms, anatomical targets, and therapeutic requirements. Although arthritis is not primarily a pharmacokinetic disorder, several pharmacokinetic and delivery barriers can limit treatment. These include rapid synovial-fluid turnover, vascular and lymphat...

Can Large Language Models Preserve Diagnostic Accuracy Despite Patient Self-Diagnosis and Framing Bias in Hypothetical Upper-Extremity Scenarios?

PURPOSE: Online health queries are often addressed by large language models (LLMs) embedded in search engines. It is possible that LLMs, like human cl...

Apigenin Alleviates Ligamentum Flavum Ossification by Dual-Targeting CA9 and CDK6 and Modulating Calcium/PI3K-Akt Signaling.

While apigenin shows therapeutic potential for bone-related disorders like osteoporosis and osteoarthritis, its mechanisms in regulating ligamentum fl...

Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging.

OBJECTIVE: The interplay between periodontitis (PD) and rheumatoid arthritis (RA) is well recognized, with aging being a central risk factor for both....

AI-derived Histopathological Signatures Are Associated With Response to Mepolizumab in Chronic Rhinosinusitis With Nasal Polyps.

BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease with variable response to biologic therapy. Tissue...

Two-stage deep learning framework for magnetic resonance imaging-based detection of temporomandibular joint osteoarthritis.

OBJECTIVES: Cone-beam computed tomography (CBCT) is the reference standard for detecting osseous changes in temporomandibular joint osteoarthritis (TM...

Molecular clustering in osteoarthritis primary tissues identifies shared inflammatory and tissue-specific pathway profiles.

OBJECTIVES: To disentangle the molecular heterogeneity of knee osteoarthritis (OA) through the classification and characterization of transcriptomic c...

Microbiome-Driven Precision Medicine in Asthma: Roles of Targeted Therapies and Artificial Intelligence.

OBJECTIVE: To evaluate the current evidence regarding airway and gut microbiome alterations in asthma pathogenesis and therapeutic response, and to ex...

Clinical Validation of Artificial Intelligence (AI)-based Cartilage Segmentation Predicting Knee Replacement.

OBJECTIVE: For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human inter...

Clustering of rheumatoid arthritis patients: an unsupervised machine learning approach for characterizing the TNFi response.

This study aimed to identifydistinct profiles of response to Tumor Necrosis Factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients using unsup...

Antimony- and NSAID-Induced Hepatotoxicity at the Molecular Crossroads: Redox, Inflammasome and Programmed Cell-Death Networks as Therapeutic Targets for Natural Hepatoprotective Agents.

Drug- and metal-induced liver damage (DILI/MILI) continues to be a predominant cause of acute hepatic failure globally, with two clinically significan...

Automated diagnostic system for classification of progression stages of osteoarthritis using magnetic resonance imaging.

INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage loss, synovial fluid imbalance, and bone structural chang...

GPCR Biology-Informed Drug Discovery in Asthma.

Advances in GPCR biology and drug-discovery technology are simultaneously reshaping what can be targeted in asthma and how those strategies must be va...

Thigh muscle volume change is associated with longitudinal structural and functional knee osteoarthritis progression - Data from the osteoarthritis initiative.

OBJECTIVE: To investigate the association of change in thigh muscle volume (TMV) with structural knee changes and changes in knee pain and functional ...

Disarming cGAS-STING hyperactivation in autoimmune and inflammatory diseases: Pathogenic mechanisms and emerging therapeutic strategies.

Aberrant activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has been increasingly recognized as a key dri...

Rapid Resolution of Hypoxemia is Common and Associated with Lower Mortality Among Intubated Patients with Acute Hypoxemic Respiratory Failure.

ObjectiveTo evaluate the prevalence, clinical trajectory, and biologic phenotype of patients with rapidly improving acute hypoxemic respiratory failur...

Artificial intelligence in dermatologic pharmacokinetics: quantitative modeling, clinical translation, and optimization of precision therapeutics.

INTRODUCTION: Dermatology is rapidly transitioning from broad-spectrum therapies toward biologics, nanotechnology-based drug delivery, and precision t...

rs57494551 increases CXCR5 expression and IgM+ CXCR5+ B-cell infiltration in the portal area of primary biliary cholangitis.

BACKGROUND: Primary biliary cholangitis (PBC) is a chronic, progressive, cholestatic liver disease caused by autoimmune reactions. A previous internat...

Associations Between Deep Learning-Derived Infrapatellar Fat Pad Volume on MRI with Cartilage Thickness and Imaging Features of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

OBJECTIVE: To investigate associations between infrapatellar fat pad volume (IPFPVol) measured on MRI with imaging features of knee osteoarthritis. DE...