Atherosclerosis

Dysfunction of the neurovascular unit as a temporal driver in Alzheimer's pathogenesis.

Extensive studies have shown that cerebrovascular dysfunction is a critical factor in the onset and progression of Alzheimer's disease (AD). Neurovascular unit (NVU) is impaired in AD brains, including damage of tight junction between endothelial cells, degeneration of pericytes, activation of astrocytes and microglia, and apoptosis of neurons. As decreased cerebral blood flow is observed before a...

FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling.

Systemic sclerosis (SSc) is characterized by fibrosis and vasculopathy affecting the skin and internal organs, leading to multiorgan dysfunction. Injury of microvascular endothelial cells (ECs) in SSc impairs blood flow and causes tissue ischemia, leading to vascular complications such as Raynaud's, digital ulcers, and pulmonary hypertension (PH). PH in SSc presents as group 1 pulmonary arterial h...

Plaque-Level Machine Learning Prediction of Intraplaque Hemorrhage in Carotid Arteries Using Computed Tomography Angiography.

BACKGROUND: Carotid artery plaques, especially those with intraplaque hemorrhage (IPH), are significant contributors to ischemic stroke. Although high...

Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysis.

Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological...

Prevalence of Lipoprotein(a) Testing in Patients With Atherosclerotic Cardiovascular Disease Within a Large Australian Cardiology Network.

BACKGROUND: Increased lipoprotein(a) (Lp[a]) is a genetically determined causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Histor...

Single-Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5-Mediated M1 Polarization.

BACKGROUND: Thoracic aortic aneurysm (TAA) is a life-threatening disease with limited therapeutic options, largely due to an incomplete understanding ...

Deep learning-based early prediction of carotid plaque response to lipid-lowering therapy using longitudinal multimodal ultrasound imaging.

OBJECTIVE: This study aimed to develop and validate a deep learning prediction model using longitudinal multimodal ultrasound imaging for early identi...

Risk prediction models for incident heart failure: a systematic review and meta-analysis.

BACKGROUND: Early identification of patients at risk of heart failure (HF) provides opportunities for preventative management. Though models have been...

Detection of calcified plaques: comparison between coronary CT angiography and thin-slice non-contrast CT with deep learning-aided image registration.

OBJECTIVES: To investigate whether coronary CT angiography (CCTA) misses calcified plaques detected by thin-slice non-contrast CT (NCCT). MATERIALS AN...

Coronary Computed Tomography and Artificial Intelligence-based Plaque Analysis.

Multimodal imaging in left main and bifurcation revascularization: contemporary evidence and comparative modalities review.

Left main (LM) and bifurcation coronary artery disease (CAD) are anatomically complex lesions which require detailed planning and precise execution fo...

Molecular Biomarkers and Risk Prediction Models for Acute Kidney Injury Following Liver Transplantation: A Review.

Liver transplantation is the definitive treatment for end-stage liver disease; however, postoperative acute kidney injury (AKI) affects 30%-70% of rec...

Comparative Evaluation of 3D-QALAS Myelin Volume Fraction, Inhomogeneous Magnetization Transfer, and Myelin Water Fraction.

BACKGROUND AND PURPOSE: Accurate in vivo quantification of myelin remains challenging despite advances in MRI. We evaluated three-dimensional syntheti...

STC2-mediated calcium homeostasis dysregulation in the osteosarcoma microenvironment: Insights from single-cell sequencing and machine learning.

BACKGROUND: Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. Dysregulated calcium homeostasis may contribute to OS progressio...

Deep learning for carotid Doppler spectra classification.

Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis.

Artificial Intelligence-Guided Quantitative Coronary CT Assessment to Rule-In or Rule-Out Myocardial Ischemia.

AIMS: To evaluate the ability of AI-based quantitative CT (AI-QCT) parameters, diameter stenosis, percent atheroma volume (PAV) and average lumen area...

Artificial Intelligence-Empowered Image Fusion of Coronary Computed Tomography Angiography and Invasive Angiography for Guiding Chronic Total Occlusion Percutaneous Coronary Intervention.

Coronary computed tomography angiography (CCTA) provides qualitative and quantitative characteristics of atherosclerotic plaques, quantified percentag...

[Annual advances in clinical applications of pulmonary function testing 2025].

This review systematically synthesizes and critically appraises domestic and international advances in pulmonary function tests (PFT) research and cli...

Identification of mitochondria-related genes in calcific aortic valve disease by integrated analysis of single-cell and bulk transcriptomic atlases.

UNLABELLED: Calcific aortic valve disease (CAVD) is a highly prevalent heart valve disorder in which mitochondria act as critical regulators of calcif...