Atherosclerosis

Single-cell sequencing combined with transcriptome sequencing to reveal the molecular mechanisms related to integrated stress responses in atherosclerosis.

Adiposome Lipidomic Shifts Following Bariatric Surgery in Association With Weight Loss and Cardiometabolic Benefit.

CONTEXT: Adiposomes carry bioactive lipids that shape systemic metabolism and vascular function. OBJECTIVE: Building on our previous findings that obese adiposomes are ceramide/free fatty acid-enriched and linked to dysfunction, we tested whether bariatric surgery remodels adiposome lipidomes and whether these shifts track with metabolic and vascular improvements. METHODS: Twenty-three obese indiv...

Development and validation of stability prediction models for intracranial aneurysms based on ensemble learning algorithms.

OBJECTIVE: This study aims to develop and validate ensemble learning models based on pre-rupture or pre-growth images andmultiple features to predict ...

Comment on: "Geometric deep learning for local growth prediction on abdominal aortic aneurysm surfaces".

Machine learning for predicting macrophage activation syndrome in adult patients with Still's disease.

BACKGROUND: Macrophage activation syndrome (MAS) secondary to Still's disease is a potentially fatal complication, associated with mortality rates exc...

Use of continuous glucose monitoring to stratify individuals without diabetes.

BACKGROUND: Early detection of metabolic dysfunction before diabetes onset remains a critical challenge in preventive medicine. Although glucose dynam...

A Machine learning pipeline to investigate tissue ingrowth in cerebral aneurysms using preclinical animal models.

Cerebral aneurysm is a life-threatening condition characterized by the formation of a saccular bulge in brain blood vessels, which can rupture and lea...

Metabolic networks in the tumor microenvironment: roles of amino acid and lipid metabolism pathways in cancer progression and therapy.

Metabolic rewiring, a defining hallmark of cancer, sustains cell proliferation and biosynthesis while coordinating adaptive interactions within the tu...

Dual coordinate attention (DCA) network for accurate cerebral vascular endothelium segmentation in OCT images.

Clustering of cardiovascular risk factors and their association with socio-demographic and lifestyle factors in middle-aged and older adults in rural northeast South Africa: Findings from HAALSI.

OBJECTIVES: This study examined patterns of clustering of intermediate risk factors for Cardiovascular diseases (CVDs) in a rural South African popula...

From genes to diagnosis: The impact of UNC5B and DOK5 in intracranial aneurysm detection and pathogenesis.

OBJECTIVE: Intracranial aneurysms exhibit a notable prevalence within the general population, characterized by an incidence rate ranging from 1% to 2%...

Immune-activated & pathology-characterized: the distinct clear cell renal cell carcinoma subtypes for 3PM strategies derived from artificial intelligence in multi-omics.

BACKGROUND AND OBJECTIVE: Renal clear cell carcinoma (ccRCC) is highly heterogeneous, with significant differences in clinical outcomes such as progno...

Illuminating the Invisible: Translational Molecular Imaging in Cardiovascular Medicine.

Cardiovascular disease remains the predominant cause of global morbidity and mortality, with recent epidemiological trends indicating a resurgence in ...

Cardiogenic Shock Revisited: From Hemodynamic-Centric to Multimodal Precision Care.

Cardiogenic shock (CS) remains a major clinical challenge, with persistently high short-term mortality despite advances in reperfusion therapy, pharma...

Association of the estimated glucose disposal rate combined with a body shape index with all-cause and cardiovascular-specific mortality among individuals with cardiovascular-kidney-metabolic syndrome.

BACKGROUND: Individuals with cardiovascular-kidney-metabolic (CKM) syndrome exhibit a substantially elevated risk of all-cause and cardiovascular-spec...

Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling.

Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molecular drivers remain unclear and better risk predic...

The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator.

Oral dysbiosis, particularly through periodontal disease, links strongly to cardiovascular risks by driving chronic inflammation and microbial translo...

Multi-omics investigation of benzo[a]pyrene in gastric cancer: comprehensive network toxicology, machine learning and molecular docking approaches.

Gastric cancer (GC) risk is shaped by environmental exposures such as benzo[a]pyrene (BaP). Here, we systematically identified BaP-toxicological targe...

Exploring the mechanism of polymorphonuclear neutrophils against sepsis based on immune model.

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and remains a major global health chall...

Machine learning and free energy clustering reveal PAH protein binding linked to AD risk.

This study develops a computational framework integrating bioinformatics, machine learning, and ΔG clustering to prioritize polycyclic aromatic hydroc...