Atherosclerosis

Monocyte-to-HDL ratio (MHR) is associated with overall and renal mortality in community-dwelling older individuals with chronic kidney disease (CKD).

From non-specific biomarker to targeted action: transdiagnostic and sex-specific drivers of high-CRP status in severe mental illness across the FondaMental Advanced Centers of Expertise (FACE) cohorts.

BACKGROUND AND OBJECTIVES: Low-grade systemic inflammation contributes to the pathophysiology of severe mental illness (SMI) in a substantial subset of patients, who often experience greater disease burden and poorer treatment response. Elevated C-reactive protein (CRP), defined as CRP ≥ 3 mg/L, has been proposed to identify this group, but its non-specificity limits the biomarker's ability to gui...

Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis.

Atherosclerosis (AS), a chronic inflammatory process driven largely by macrophage-mediated plaque formation, remains poorly understood in mitochondria...

Subphenotypes in acute respiratory distress syndrome: A scoping review across clinical, biological, computational, imaging, omics, and artificial intelligence approaches.

BACKGROUND: Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with high mortality. Subphenotyping may identify more homogeneous g...

Correlative analysis between ocular surface features and carotid plaque : A multimodal machine learning framework.

BACKGROUND AND OBJECTIVE: The diagnosis of carotid plaques plays an important role in revealing cardiovascular and cerebrovascular diseases, thus attr...

Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging Study.

BACKGROUND: Abdominal aortic calcification (AAC) is a subclinical measure of atherosclerotic cardiovascular disease (ASCVD). AAC can be captured on la...

Nanoengineered Surface-Enhanced Raman Spectroscopy Substrates for Probing Tissue-Material Interactions.

Innovation in biomaterials has brought both breakthroughs and challenges in medicine, as implant materials have become increasingly multifunctional an...

Machine learning to predict elevated lipoprotein(a).

PURPOSE OF REVIEW: Lipoprotein(a), Lp(a), is a genetically determined, lifelong risk factor for atherosclerotic cardiovascular disease (ASCVD). Despit...

Development and validation of a neural network survival prediction model for ischemic heart disease.

BACKGROUND: Current risk prediction models for ischemic heart disease in clinical use are relatively simple and use a limited collection of well-known...

Lipoprotein(a) Selectively Associates with Vulnerable Coronary Plaque Phenotypes in Comparison with Other Established Risk Markers.

AIMS: Lipoprotein(a) [Lp(a)] is an inherited cardiovascular risk factor. However, its association with coronary plaque characteristics beyond traditio...

Deep learning-based plaque characterization in hybrid IVUS-OCT images is superior to single-modality deep learning analysis and human experts: head-to-head comparison against histology.

AIMS: Hybrid intravascular ultrasound-optical coherence tomography (IVUS-OCT) can enable more accurate plaque characterization than single-modality in...

In-hospital outcomes of intravascular lithotripsy compared to rotational atherectomy and cutting/scoring balloon angioplasty.

BACKGROUND: Intravascular lithotripsy (IVL) emerged for the treatment of coronary artery calcification with encouraging safety and effectiveness rates...

Analysis of differential photoplethysmography signal patterns in apnea and hypopnea.

OBJECTIVE: Photoplethysmography, a non-invasive optical technique that measures changes in blood volume in the microvascular bed of tissue, offers a p...

Development of a machine learning-based model for prediction of diabetes risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading chronic liver disorder closely linked to diabetes mellitus (...

Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review.

Coronary atherosclerosis is a leading cause of morbidity and mortality worldwide and is characterized by complex molecular and cellular mechanisms inv...

CCTA as a Screening Tool (Invited Commentary).

Coronary computed tomography angiography (CCTA) has evolved into a key non-invasive tool for evaluating coronary artery disease, offering high sensiti...

Polyphenols as Modulators of Macrophage Polarization: Mechanisms and Therapeutic Potential in Chronic Inflammatory Diseases.

Macrophage polarization between pro-inflammatory M1 and anti-inflammatory M2 phenotypes is pivotal in chronic inflammatory diseases, offering a key th...

Trends and Scientific Evolution in Endovascular Aneurysm Repair (EVAR) Research: A Comprehensive Bibliometric Study Using VOSviewer.

BACKGROUND: Endovascular aneurysm repair (EVAR) has become a standard treatment for abdominal aortic aneurysms. However, the evolution of EVAR researc...

MRI-based multilevel radiomics and transformer features for predicting radiation-induced carotid artery injury after nasopharyngeal carcinoma radiotherapy: A multicenter study.

PURPOSE: To develop and validate an MRI-based fusion model (Rad-SRad-SwinT) integrating conventional radiomics (Rad), subregional radiomics (SRad), an...

A Synovium-on-Chip Platform to Study Multicellular Interactions in Arthritis.

Arthritis progression is modulated by the synovium, yet its cellular crosstalk remains poorly understood, partly due to the limited availability of hu...