Atherosclerosis

Dual coordinate attention (DCA) network for accurate cerebral vascular endothelium segmentation in OCT images.

Clustering of cardiovascular risk factors and their association with socio-demographic and lifestyle factors in middle-aged and older adults in rural northeast South Africa: Findings from HAALSI.

OBJECTIVES: This study examined patterns of clustering of intermediate risk factors for Cardiovascul...

From genes to diagnosis: The impact of UNC5B and DOK5 in intracranial aneurysm detection and pathogenesis.

OBJECTIVE: Intracranial aneurysms exhibit a notable prevalence within the general population, charac...

Immune-activated & pathology-characterized: the distinct clear cell renal cell carcinoma subtypes for 3PM strategies derived from artificial intelligence in multi-omics.

BACKGROUND AND OBJECTIVE: Renal clear cell carcinoma (ccRCC) is highly heterogeneous, with significa...

Illuminating the Invisible: Translational Molecular Imaging in Cardiovascular Medicine.

Cardiovascular disease remains the predominant cause of global morbidity and mortality, with recent ...

Cardiogenic Shock Revisited: From Hemodynamic-Centric to Multimodal Precision Care.

Cardiogenic shock (CS) remains a major clinical challenge, with persistently high short-term mortali...

Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling.

Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molec...

The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator.

Oral dysbiosis, particularly through periodontal disease, links strongly to cardiovascular risks by ...

Multi-omics investigation of benzo[a]pyrene in gastric cancer: comprehensive network toxicology, machine learning and molecular docking approaches.

Gastric cancer (GC) risk is shaped by environmental exposures such as benzo[a]pyrene (BaP). Here, we...

Exploring the mechanism of polymorphonuclear neutrophils against sepsis based on immune model.

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to...

Machine learning and free energy clustering reveal PAH protein binding linked to AD risk.

This study develops a computational framework integrating bioinformatics, machine learning, and ΔG c...

Guiding Preventive Care Strategies for Patients With Atherosclerotic Plaque on Coronary CTA: Primary Outcomes of the DECIDE Registry.

BACKGROUND: Artificial intelligence-enabled coronary plaque analysis (AI-CPA) has been shown to impr...

DeepStackVEGF a stacking ensemble deep learning framework for vascular endothelial growth factor prediction.

Vascular Endothelial Growth Factor (VEGF) plays a central role in angiogenesis, regulating both phys...

Investigation of Fatty Acid Metabolism-Associated Molecular CPOX and the Underlying Mechanism in Follicular Lymphoma.

Dysregulated lipid metabolism is a key driver of follicular lymphoma (FL). This study aimed to explo...

Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling.

Clear cell renal cell carcinoma (ccRCC) is characterized by high metastatic potential and frequent r...

Comparison of conventional formulas and machine learning models for estimating serum low-density lipoprotein cholesterol.

BACKGROUND: Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is essential for card...

Enhanced Transcytosis and Retention (ETR) of Drug Delivery Nanocarrier in Solid Tumors.

ConspectusTranscytosis, traditionally regarded as biological, constitutes an intrinsic and powerful ...

[Plasma proteomics in age-related macular degeneration].

BACKGROUND: Neovascular age-related macular degeneration (nAMD) shows a heterogeneous treatment resp...

Comprehensive Analysis of Bulk RNA-seq, Machine Learning, Mendelian Randomization, and Single-Cell Sequencing Unravels SLC22A3 as a Solute Carrier Superfamily-Associated Biomarker in Atherosclerosis.

Growing evidence implicates solute carrier (SLC) superfamily in atherosclerosis (AS) pathogenesis. T...

Clinical and pathologic correlations of machine learning quantification of Aβ deposits across 3 brain regions of decedents with Alzheimer disease.

Machine learning enables scalable quantification of neuropathology, offering deeper phenotyping of A...

Unveiling Endotypes in Systemic Lupus Erythematosus Through Multi-Omic Analysis: Insights into Cardiovascular and Renal Complications.

BACKGROUND: Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardi...