Atherosclerosis

Diabetic retinopathy-recommendations for screening and treatment.

Diabetic retinopathy (DR), the prevalence of which continues to rise, is one of the most common causes of vision loss worldwide. Experimental and clinical research in recent years has contributed to a better understanding of the pathogenesis of DR, which is complex and results from many interrelated processes leading to abnormal permeability and occlusion of the retinal vasculature, with ischemia ...

Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular tone, endothelial function, and inflammation. Our objectives were to identify proteins specifically secreted by foam human coronary VSMCs (foam-hcVSMC)...

Restoring AIBP expression in the retina provides neuroprotection in glaucoma.

Glaucoma is a neurodegenerative disease manifested by retinal ganglion cell (RGC) death and irreversible blindness. We have identified apolipoprotein ...

Dual-action membrane-chimeric liposomes with self-reinforcing targeting for acute lung injury treatment.

Acute lung injury (ALI) is a common acute and critical syndrome with high mortality. The uncontrollable feedback loop of inflammation is the primary c...

Hemostatic Activation Markers and Early Neurological Deterioration in Branch Atheromatous Disease-Related Stroke.

AIMS: Branch atheromatous disease (BAD)-related stroke, caused by atherosclerotic occlusion at the origin of a deep penetrating artery, are prone to e...

Adherence to SVS Abdominal Aortic Aneurysm Guidelines Among Pati ents Detected by AI-Based Algorithm.

OBJECTIVES: This study evaluates adherence to the latest Society for Vascular Surgery (SVS) guidelines on imaging surveillance, physician evaluation, ...

Periodontal disease in adolescents with type 1 diabetes mellitus: A cross link between continuous glucose monitoring-derived metrics, caspase-3 levels, diabetic nephropathy and subclinical atherosclerosis.

BACKGROUND: Periodontitis can lead to the development of atherosclerotic heart disease.

Neuroprotective Effects of Shrimp Oil Against Oxidative Stress in Chronic Cerebral Hypoperfusion Rats.

Shrimp oil is rich in polyunsaturated fatty acids and astaxanthin, which possesses high antioxidant activity. This study aimed to investigate the impa...

Advances in the application of 18F-sodium fluoride PET in the assessment of atherosclerosis.

Atherosclerosis serves as the primary cause of cardiovascular diseases (CVDs), with its pathological processes encompassing lipid deposition, inflamma...

Leafing a mark on immunity: Quercetin-3-O-D-glucopyranoside and quercetin-3-O-(2″,6″-digalloyl)-β-D-galactopyranoside-rich Melia azedarach L. extract's immunoinflammatory effects on an sRBC-immunized BALB/c model.

Melia azedarach L. (Meliaceae) (MA) leaves are traditionally used for inflammatory disorders, yet their immunomodulatory effects on lymphocytes remain...

Mechanisms and Applications of Apolipoproteins and Apolipoprotein Mimetic Peptides: Common Pathways in Cardiovascular Disease and Cancer.

Apolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprot...

Impact of the recent advances in coronary artery disease imaging on pilot medical certification and aviation safety: current state and future perspective.

Coronary artery disease (CAD) is highly prevalent among pilots due to the nature of their lifestyle, and occupational stresses. CAD is one the most co...

Invited Article: Al guided Dual Antiplatelet Therapy and Anticoagulation.

Artificial intelligence (AI) has emerged as a transformative tool in healthcare through data analysis, pattern recognition and predictive modeling cap...

PMMNet: A Dual Branch Fusion Network of Point Cloud and Multi-View for Intracranial Aneurysm Classification and Segmentation.

Intracranial aneurysm (IA) is a vascular disease of the brain arteries caused by pathological vascular dilation, which can result in subarachnoid hemo...

Machine learning-based optimization of cytotoxicity testing for assessing Zn-based biodegradable metals.

Zinc (Zn)-based biodegradable metals are emerging as promising candidates for biomedical implants. Nonetheless, discrepancies between and biocompati...

A systematic review on deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction.

BACKGROUND: Coronary artery disease (CAD) is a major worldwide health concern, contributing significantly to the global burden of cardiovascular disea...

A digital photography dataset for Vaccinia Virus plaque quantification using Deep Learning.

Virological plaque assay is the major method of detecting and quantifying infectious viruses in research and diagnostic samples. Furthermore, viral pl...

Retinal Ischemic Perivascular Lesions (RIPLs) as Potential Biomarkers for Systemic Vascular Diseases: A Narrative Review of the Literature.

Retinal ischemic perivascular lesions (RIPLs) are characteristic focal thinning of the inner nuclear layer, with an upward expansion of the outer nucl...

Application and optimization of the U-Net++ model for cerebral artery segmentation based on computed tomographic angiography images.

Accurate segmentation of cerebral arteries on computed tomography angiography (CTA) images is essential for the diagnosis and management of cerebrovas...

Predicting outcomes following open abdominal aortic aneurysm repair using machine learning.

Patients undergoing open surgical repair of abdominal aortic aneurysm (AAA) have a high risk of post-operative complications. However, there are no wi...