Atherosclerosis

Multi-omics and machine learning framework reveals ABCG2 as a therapeutic target of Eleven Flavored Shenqi Tablets in clear cell renal cell carcinoma.

ETHNOPHARMACOLOGICAL RELEVANCE: Eleven Flavored Shenqi Tablets (EFST) is a classical multi-herbal prescription in traditional Chinese medicine, traditionally prescribed for kidney tonification and systemic regulation. Despite its reported anti-inflammatory and antiproliferative properties, the therapeutic value of EFST in clear cell renal cell carcinoma (ccRCC) remains unclear. METHODS: We integra...

International Consensuses and Guidelines on Diagnosing and Managing Coats Disease by the Academia Retina Internationalis (ARI), the Asia-Pacific Vitreo-retina Society (APVRS), and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO).

PURPOSE: Coats disease is a rare, retinal vascular disorder characterized by telangiectasias, aneurysmal dilations, and progressive exudative retinal detachment. Limited understanding of the disease warranted the need to identify controversial issues through an extensive literature search and a debate and discussion among international panels of experts. METHODS: Extensive literature search was do...

Blood urea nitrogen-to-lipid ratios are novel indices inversely associated with anxiety: Insights from NHANES.

BACKGROUND: Anxiety is a highly prevalent mental disorder linked to metabolic and renal dysregulation. Blood urea nitrogen (BUN) and lipid profiles ha...

Age-specific modifiable determinants and nonlinear risk patterns of habitual low back pain in a large medical check-up cohort: a cross-sectional and longitudinal analysis.

BACKGROUND: Age-related mechanisms underlying habitual low-back pain (LBP) remain poorly defined, with most studies pooling heterogeneous populations ...

Artificial Intelligence-Based Algorithms Improve Care of Patients with AAA.

BACKGROUND: Timely detection and monitoring of abdominal aortic aneurysms (AAAs) are necessary to prevent ruptures and decrease mortality. Artificial ...

3D Convolutional Neural Network for Predicting Clinical Outcome from Coronary Computed Tomography Angiography in Patients with Suspected Coronary Artery Disease.

This study aims to develop and assess an optimized three-dimensional convolutional neural network model (3D CNN) for predicting major cardiac events f...

Uncovering the therapeutic potential of Si-Miao-Yong-An decoction in abdominal aortic aneurysm: An integrative study combining network pharmacology, machine learning, molecular docking and dynamics simulation.

Abdominal aortic aneurysm (AAA) is a progressive and life-threatening vascular disorder characterized by abnormal dilation of the abdominal aorta and ...

Development of an interpretable machine learning model to predict short-term bleeding risk in patients receiving dual antithrombotic therapy following cardiac surgery.

INTRODUCTION: Bleeding is a serious complication in cardiac surgery, especially among patients receiving combined anticoagulant and antiplatelet thera...

Tissue-Engineered Endothelial Keratoplasty with Controlled Cell Density: Toward Super TEEKs.

Over the past 20 years, endothelial keratoplasty procedures have revolutionized the treatment of corneal endothelial disorders. These conditions have ...

Artificial intelligence in age-related macular degeneration: Advancing diagnosis, prognosis, and treatment.

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults. While anti-vascular endothelial growth factor (...

Comparison of the Diagnostic Utility of Computed Tomography Angiography Head With and Without 3-Dimensional Volume-Rendered Images for Aneurysm Detection in Subarachnoid Hemorrhage Patients Versus Digital Subtraction Angiography.

BACKGROUND AND OBJECTIVES: Generating computed tomography (CT) angiography (CTA) 3-dimensional (3D) volume-rendered (3DVR) images can be time consumin...

Identification of key genes in intracranial aneurysm via WGCNA: insights into immune microenvironment and therapeutic targets.

BACKGROUND: Intracranial aneurysms (IA) are prevalent vascular lesions whose rupture causes subarachnoid hemorrhage with high disability and mortality...

Evaluation of deep learning models for anterior segment OCT image segmentation during scleral lens wear.

PURPOSE: The accurate segmentation of corneal and contact lens boundaries in anterior segment optical coherence tomography (AS-OCT) images provides es...

Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group.

Coronary CT angiography is widely implemented, with an estimated 2.2 million procedures in patients with stable chest pain every year in Europe alone....

Pre-interventional transesophageal echocardiography as a reliable predictor of residual shunt following patent foramen ovale closure.

BACKGROUND: Closure of a patent foramen ovale (PFO) is an effective strategy in the prevention of recurrent stroke after cryptogenic stroke. Residual ...

Emerging innovations in ophthalmic drug delivery for diabetic retinopathy: a translational perspective.

Diabetic retinopathy (DR) is a progressive microvascular complication of diabetes and a leading cause of vision impairment worldwide. Despite advancem...

Incidental Finding of Coronary and Non-Coronary Artery Calcium: What Do Clinicians Need To Know?

PURPOSE OF REVIEW: This review summarizes the role of incidentally and non-incidentally discovered coronary artery calcification (CAC) and the evolvin...

Development and validation of a prognostic model for predicting survival and immunotherapy benefits in melanoma based on metabolism-relevant genes.

Skin cutaneous melanoma (SKCM) is a fatal form of skin cancer. Metabolism-related genes (MRGs) comprise a group of genes that possess the ability to m...

Identification of diagnostic biomarkers and dissecting immune microenvironment with crosstalk genes in the POAG and COVID-19 nexus.

An underlying association between primary open-angle glaucoma (POAG) and COVID-19 has been hypothesized, but the causal link and shared mechanisms rem...

Screening and investigating the regulatory mechanisms of oxidative stress-related biomarkers in thoracic aortic aneurysms.

Excess reactive oxygen species leading to oxidative stress has been identified as a significant factor in cardiovascular disease. However, the molecul...