Atherosclerosis

Mild to moderate COPD, vitamin D deficiency, and longitudinal bone loss: the Multi-ethnic Study of Atherosclerosis.

OBJECTIVE: Despite the established association between chronic obstructive pulmonary disease (COPD) severity and risk of osteoporosis, even after accounting for the known shared confounding variables (e.g., age, smoking, history of exacerbations, steroid use), there is paucity of data on bone loss among mild to moderate COPD, which is more prevalent in the general population.

Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula.

AIMS: This study investigates the role of macrophage histone lactylation-a protein modification-in atherosclerosis progression, particularly in peripheral artery disease (PAD), and evaluates the therapeutic potential of the herbal formula Ruan Jian Qing Mai (RJQM).

Evaluating anti-VEGF responses in diabetic macular edema: A systematic review with AI-powered treatment insights.

Recent advances in deep learning and machine learning have greatly increased the capabilities of extracting features for evaluating the response to an...

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic-Fluorescence Imaging.

Advances in organoid models, as ex vivo mini-organs, and the development of screening imaging technologies have continuously driven each other forward...

High burden of premature ventricular contractions upregulates transcriptional markers of inflammation and promotes adverse cardiac remodeling linked to cardiomyopathy.

Premature ventricular contractions (PVCs) are the most prevalent ventricular arrhythmia in adults. High PVC burden can lead to left ventricular (LV) s...

Drug repurposing to identify potential FDA-approved drugs targeting three main angiogenesis receptors through a deep learning framework.

Tumor cell survival depends on the presence of oxygen and nutrients provided by existing blood vessels, particularly when cancer is in its early stage...

The Emerging Role of Computed Tomography Coronary Angiography in the Left Main Stem Percutaneous Coronary Intervention.

Recent advancements in computed tomography have significantly transformed the clinical application of this technique in diagnosing and managing corona...

Artificial intelligence-derived coronary plaque features predict incident acute ischaemic stroke independent of cardioembolic risk factors.

Integrative Machine Learning Approach to Explore Glycosylation Signatures and Immune Landscape in Moyamoya Disease.

Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder of uncertain etiology. Although abnormal glucose metabolism has been implicated, th...

A Joint Geometric Topological Analysis Network (JGTA-Net) for Detecting and Segmenting Intracranial Aneurysms.

OBJECTIVE: The rupture of intracranial aneurysms leads to subarachnoid hemorrhage. Detecting intracranial aneurysms before rupture and stratifying the...

Aging at the Crossroads of Organ Interactions: Implications for the Heart.

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate ag...

Identification of shared mechanisms between Alzheimer's disease and atherosclerosis by integrated bioinformatics analysis.

Alzheimer's disease (AD) and atherosclerosis (AS) are two interacting diseases mostly affecting aged adults. AD is characterized by the deposition of ...

Integration of machine learning and bulk sequencing revealed exosome-related gene FOSB was involved in the progression of abdominal aortic aneurysm.

BACKGROUND: Abdominal aortic aneurysm (AAA), characterized by the pathological dilation of the abdominal aorta, was associated with immune response an...

Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.

BACKGROUND AND OBJECTIVE: Atherogenicity indices have emerged as promising markers for cardiometabolic disorders, yet their relationship with prediabe...

Intercellular communication in the brain via dendritic nanotubular network.

Recent studies have identified intercellular networks for material exchange by bridge-like nanotubular structures, yet their existence in neurons rema...

Associations of the Hs-CRP/HDL-C ratio with stroke among US adults: Evidence from NHANES 2015-2018.

BACKGROUND: The high-sensitivity C-reactive protein (Hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio, which integrates insights into inf...

Integrating Artificial Intelligence and Precision Therapeutics for Advancing the Diagnosis and Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex molecular mechanisms, including genetic susceptibilit...

Contemporary Prevention and Management of Postoperative Delirium in Cardiac Surgery Patients.

This review examines the prevention and management of postoperative delirium in cardiac surgery patients, a frequent complication linked with signific...

Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.

Alzheimer's disease (AD), the most common form of dementia, is marked by cognitive decline and amyloid-beta (Aβ) plaque deposition in the brain. Micro...

Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases.

This study developed a new Cellular Omics-Structural Integration (COSI) technology platform to address the limitation of traditional technologies in s...