Atherosclerosis

Radiomic Carotid Plaque Features Integrated into Machine Learning Models for Cardiovascular Risk Prediction.

OBJECTIVE: Carotid plaque detected by ultrasound is associated with major adverse cardiovascular events (MACE) and can be characterized using manual or automated radiomic analysis. The generated plaque characteristics may have complex interdependencies for which machine learning (ML) may provide predictive modeling. The objective of the study was to develop a ML model to predict MACEs from clinica...

Time-to-event ensemble machine learning approach for predicting long-term survival of abdominal aortic aneurysm patients undergoing endovascular aneurysm repair.

BACKGROUND: Endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) is associated with risks such as endoleaks and late aneurysm rupture, highlighting the importance of long-term survival prediction. Despite recent advancements in machine learning (ML), predictive models utilizing time-to-event analysis remain limited for AAA patients undergoing EVAR. We aimed to develop a stacking...

AI-Guided Patient-Derived Endothelial Modeling Identifies a Reversible Moyamoya-Specific miRNA Deficiency Corrected by Stem Cell-Extracellular Vesicles.

Moyamoya disease (MMD) is a progressive cerebrovascular disorder characterized by abnormal vascular remodeling and impaired angiogenesis. We profiled ...

Slow-wave-modulated high-frequency oscillations reveal early network abnormalities in pre-pathological 5XFAD mice.

Alzheimer's disease (AD) is characterized by progressive disruption of large-scale neural networks, leading to abnormal brain oscillatory activity, ye...

Extracranial vascular association of moyamoya disease: a systematic review and machine learning analysis.

BACKGROUND: Intracranial steno-occlusive lesions are characteristic of moyamoya disease (MMD), but increasing reports of extracranial vascular involve...

Peripheral and central immune features in insomnia: Integrative bulk and single-cell transcriptomic analyses reveal core hub genes and candidate compounds.

Insomnia is closely associated with immune dysregulation, yet the overall pattern of peripheral-central immune disequilibrium and its underlying molec...

Streetview greenspace types and dementia risk in older adults: The Multi-Ethnic Study of Atherosclerosis.

BACKGROUND: Greenspace has been associated with lower dementia risk but most studies have used satellite-derived measures that cannot distinguish vege...

Combinations of single gene predictors with AI-driven polygenic precision therapies in cardiovascular diseases.

Pharmacogenomics (PGx) is transforming how we treat cardiovascular disease (CVD) by enabling us to select and dose drugs based on our genetic profiles...

Hybrid vision transformer and ensemble machine learning framework for automated atherosclerotic plaque classification in intravascular ultrasound imaging.

Atherosclerotic plaque classification in intravascular ultrasound (IVUS) imaging is crucial for cardiovascular disease diagnosis and treatment plannin...

Deciphering the potential molecular links between ochratoxin A and colorectal cancer: an integrated computational toxicological and single-cell transcriptomic study.

BACKGROUND: Ochratoxin A (OTA), a common foodborne mycotoxin, is classified as a potential human carcinogen. However, the specific molecular mechanism...

The emerging role of coronary computed tomography for prevention of cardiovascular disease in asymptomatic individuals.

The persistent global rise in atherosclerotic cardiovascular disease (ASCVD) challenges the effectiveness of current risk factor-based algorithms in p...

A quarter-century of progress: innovations in lipid medicine that transformed cardiovascular prevention.

This TimeCapsule reviews the major transformations in lipid metabolism and cardiovascular disease prevention during the first quarter of the 21st cent...

High-risk carotid plaque detection using a novel radio-morphometric analysis of the carotid bifurcation.

Current surgical eligibility criteria for the treatment of carotid artery disease, primary relying on stenosis and image plaque characteristics, are s...

Association of the CHG Index with the onset, progression, and prognosis of cardiovascular-kidney-metabolic syndrome: findings from two large prospective cohorts.

BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome represents a composite disease state driven by glucose and lipid metabolic dysregulation. T...

No-reflow phenomenon during percutaneous coronary intervention: Contemporary insights into mechanisms, prediction, and management.

No-reflow phenomenon remains a common and prognostically adverse complication of percutaneous coronary intervention (PCI), characterized by impaired m...

Integrated multi-omics and experimental validation reveal CSK and FBLN1 as key targets of stanozolol in accelerating atherosclerosis.

BACKGROUND: Stanozolol, a synthetic anabolic androgenic steroid (AAS) widely abused to enhance performance, has poorly defined toxicological mechanism...

ACADM-mediated fatty acid β-oxidation pathway in atherosclerosis and abdominal aortic aneurysm.

BACKGROUND AND AIMS: Atherosclerosis (AS) and abdominal aortic aneurysm (AAA) are both metabolism-associated vascular diseases, yet the role of lipid ...

Deep Multi-Task Attention Network for Automated, Reproducible Quantification of Carotid Plaque Burden in Ultrasound Imaging.

Carotid atherosclerotic plaque burden is a well-established biomarker of cerebrovascular and cardiovascular risk, yet its quantitative assessment from...

Development, internal testing, and external validation of an interpretable machine-learning model for predicting imaging-confirmed in-hospital postoperative deep vein thrombosis in older patients with patellar fractures.

BACKGROUND: Older patients with patellar fractures may be at increased risk of postoperative deep vein thrombosis (DVT) because of trauma, perioperati...

An explainable machine learning method for identifying key atherogenic lipid biomarkers in abdominal obesity among the Southern Chinese population.

BACKGROUND: Abdominal obesity (AO) significantly contributes to cardiometabolic diseases and poses an increasing public health challenge. Composite li...