Brain Cancer

Transforming Multimodal Models into Action Models for Radiotherapy

Radiotherapy is a crucial cancer treatment that demands precise planning to balance tumor eradication and preservation of healthy tissue. Traditional treatment planning (TP) is iterative, time-consuming, and reliant on human expertise, which can potentially introduce variability and inefficiency. We propose a novel framework to transform a large multimodal foundation model (MLM) into an action m...

A Self-supervised Multimodal Deep Learning Approach to Differentiate Post-radiotherapy Progression from Pseudoprogression in Glioblastoma

Accurate differentiation of pseudoprogression (PsP) from True Progression (TP) following radiotherapy (RT) in glioblastoma (GBM) patients is crucial for optimal treatment planning. However, this task remains challenging due to the overlapping imaging characteristics of PsP and TP. This study therefore proposes a multimodal deep-learning approach utilizing complementary information from routine a...

Gamma/hadron separation in the TAIGA experiment with neural network methods

In this work, the ability of rare VHE gamma ray selection with neural network methods is investigated in the case when cosmic radiation flux strongl...

Computational modelling of cancer nanomedicine: Integrating hyperthermia treatment into a multiphase porous-media tumour model

Heat-based cancer treatment, so-called hyperthermia, can be used to destroy tumour cells directly or to make them more susceptible to chemotherapy o...

Augmented Intelligence for Multimodal Virtual Biopsy in Breast Cancer Using Generative Artificial Intelligence

Full-Field Digital Mammography (FFDM) is the primary imaging modality for routine breast cancer screening; however, its effectiveness is limited in ...

Glioma Multimodal MRI Analysis System for Tumor Layered Diagnosis via Multi-task Semi-supervised Learning

Gliomas are the most common primary tumors of the central nervous system. Multimodal MRI is widely used for the preliminary screening of gliomas and...

Fine-Tuning Open-Source Large Language Models to Improve Their Performance on Radiation Oncology Tasks: A Feasibility Study to Investigate Their Potential Clinical Applications in Radiation Oncology

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language mode...

Z-Stack Scanning can Improve AI Detection of Mitosis: A Case Study of Meningiomas

Z-stack scanning is an emerging whole slide imaging technology that captures multiple focal planes alongside the z-axis of a glass slide. Because z-...

Marker Track: Accurate Fiducial Marker Tracking for Evaluation of Residual Motions During Breath-Hold Radiotherapy

Fiducial marker positions in projection image of cone-beam computed tomography (CBCT) scans have been studied to evaluate daily residual motion duri...

Leveraging Multiphase CT for Quality Enhancement of Portal Venous CT: Utility for Pancreas Segmentation

Multiphase CT studies are routinely obtained in clinical practice for diagnosis and management of various diseases, such as cancer. However, the CT ...

Synthetic CT image generation from CBCT: A Systematic Review

The generation of synthetic CT (sCT) images from cone-beam CT (CBCT) data using deep learning methodologies represents a significant advancement in ...

Bidirectional Brain Image Translation using Transfer Learning from Generic Pre-trained Models

Brain imaging plays a crucial role in the diagnosis and treatment of various neurological disorders, providing valuable insights into the structure ...

Transfer Learning Strategies for Pathological Foundation Models: A Systematic Evaluation in Brain Tumor Classification

Foundation models pretrained on large-scale pathology datasets have shown promising results across various diagnostic tasks. Here, we present a syst...

Training-Aware Risk Control for Intensity Modulated Radiation Therapies Quality Assurance with Conformal Prediction

Measurement quality assurance (QA) practices play a key role in the safe use of Intensity Modulated Radiation Therapies (IMRT) for cancer treatment....

Efficient Deep Learning-based Forward Solvers for Brain Tumor Growth Models

Glioblastoma, a highly aggressive brain tumor, poses major challenges due to its poor prognosis and high morbidity rates. Partial differential equat...

From Images to Insights: Transforming Brain Cancer Diagnosis with Explainable AI

Brain cancer represents a major challenge in medical diagnostics, requisite precise and timely detection for effective treatment. Diagnosis initiall...

End-to-End Deep Learning for Interior Tomography with Low-Dose X-ray CT

Objective: There exist several X-ray computed tomography (CT) scanning strategies to reduce a radiation dose, such as (1) sparse-view CT, (2) low-do...

Generative Style Transfer for MRI Image Segmentation: A Case of Glioma Segmentation in Sub-Saharan Africa

In Sub-Saharan Africa (SSA), the utilization of lower-quality Magnetic Resonance Imaging (MRI) technology raises questions about the applicability o...

Deep Learning-based Feature Discovery for Decoding Phenotypic Plasticity in Pediatric High-Grade Gliomas Single-Cell Transcriptomics

By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the s...

Mechanistic modeling and machine learning identifies optimum radiotherapy schedules to prevent treatment-induced metastasis

Lung cancer patients often experience increased metastasis formation after radiotherapy. However, it is incompletely understood whether radiation affe...