Breast Cancer

Organoid-Guided Precision Medicine: From Bench to Bedside.

Organoid technology, as an emerging field within biotechnology, has demonstrated transformative potential in advancing precision medicine. This review systematically outlines the translational trajectory of organoids from bench to bedside, emphasizing their construction methodologies, key regulatory factors, and multifaceted applications in personalized healthcare. By recapitulating physiological ...

Deep learning-based classification of coronary arteries and left ventricle using multimodal data for autonomous protocol selection or adjustment in angiography.

Optimal selection of X-ray imaging parameters is crucial in coronary angiography and structural cardiac procedures to ensure optimal image quality and minimize radiation exposure. These anatomydependent parameters are organized into customizable organ programs, but manual selection of the programs increases workload and complexity. Our research introduces a deep learning algorithm that autonomousl...

Evaluation of deliverable artificial intelligence-based automated volumetric arc radiation therapy planning for whole pelvic radiation in gynecologic cancer.

This study aimed to develop a deep learning (DL)-based deliverable whole pelvic volumetric arc radiation therapy (VMAT) for patients with gynecologic ...

A machine learning tool for prediction of vertebral compression fracture following stereotactic body radiation therapy for spinal metastases.

BACKGROUND AND PURPOSE: The most common adverse event following spine stereotactic body radiotherapy (SBRT) is vertebral compression fracture (VCF). T...

Assessing ChatGPT for clinical decision-making in radiation oncology, with open-ended questions and images.

PURPOSE: This study assesses the practicality and correctness of ChatGPT-4 and 4O's answers to clinical inquiries in radiation oncology, and evaluates...

Detection of pathologic complete response using deep neural network-based endoscopic evaluation in patients with esophageal cancer receiving neoadjuvant chemotherapy: a nationwide multicenter retrospective study from 46 Japanese esophageal centers.

BACKGROUND: Detecting pathological complete response (pCR) preoperatively facilitated a non-surgical approach after neoadjuvant chemotherapy (NAC). We...

Mexican dataset of digital mammograms (MEXBreast) with suspicious clusters of microcalcifications.

Breast cancer is one of the most prevalent cancers affecting women worldwide. Early detection and treatment are crucial in significantly reducing mort...

Deep learning for malignant lymph node segmentation and detection: a review.

Radiation therapy remains a cornerstone in the treatment of cancer, with the delineation of Organs at Risk (OARs), tumors, and malignant lymph nodes p...

Integrating attention networks into a hybrid model for HER2 status prediction in breast cancer.

Breast cancer is one of the most prevalent cancers amongst women, caused by uncontrolled cell growth in breast tissue. Human Epidermal growth factor R...

Development and validation of an interpretable machine learning model for diagnosing pathologic complete response in breast cancer.

BACKGROUND: Pathologic complete response (pCR) following neoadjuvant chemotherapy (NACT) is a critical prognostic marker for patients with breast canc...

Reinforcement learning-driven automated head and neck simultaneous integrated boost (SIB) radiation therapy: flexible treatment planning aligned with clinical preferences.

Head-and-neck simultaneous integrated boost (SIB) treatment planning using intensity modulated radiation therapy is particularly challenging due to th...

Machine learning prediction of HER2-low expression in breast cancers based on hematoxylin-eosin-stained slides.

BACKGROUND: Treatment with HER2-targeted therapies is recommended for HER2-positive breast cancer patients with HER2 gene amplification or protein ove...

Fully Automated Online Adaptive Radiation Therapy Decision-Making for Cervical Cancer Using Artificial Intelligence.

BACKGROUND: Interfraction variations during radiation therapy pose a challenge for patients with cervical cancer, highlighting the benefits of online ...

Feasibility of U-Net model for cerebral arteries segmentation with low-dose computed tomography angiographic images with pre-processing methods.

Subtraction computed tomography angiography (sCTA) can effectively separate enhanced cerebral arteries from similar signal intensity and proximity (i....

Development of a GPT-4-Powered Virtual Simulated Patient and Communication Training Platform for Medical Students to Practice Discussing Abnormal Mammogram Results With Patients: Multiphase Study.

BACKGROUND: Standardized patients (SPs) prepare medical students for difficult conversations with patients. Despite their value, SP-based simulation t...

Learning Chemotherapy Drug Action via Universal Physics-Informed Neural Networks.

OBJECTIVE: Quantitative systems pharmacology (QSP) is widely used to assess drug effects and toxicity before the drug goes to clinical trial. However,...

Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

OBJECTIVE: Despite growing interest in neoadjuvant therapies, there are no methods to predict radio- (RT) or chemoradiotherapy (CRT) response in head ...

Enhancing security in electromagnetic radiation therapy using fuzzy graph theory.

This research investigates the application of fuzzy graph theory to address critical security challenges in electromagnetic radiation therapy systems....

The role of patient outcomes in shaping moral responsibility in AI-supported decision making.

INTRODUCTION: Integrating decision support mechanisms utilising artificial intelligence (AI) into medical radiation practice introduces unique challen...

Integrating Machine Learning and Bulk and Single-Cell RNA Sequencing to Decipher Diverse Cell Death Patterns for Predicting the Prognosis of Neoadjuvant Chemotherapy in Breast Cancer.

Breast cancer (BRCA) continues to pose a serious risk to women's health worldwide. Neoadjuvant chemotherapy (NAC) is a critical treatment strategy. Ne...