Chemotherapy

Assessing the quality and readability of patient education materials on chemotherapy cardiotoxicity from artificial intelligence chatbots: An observational cross-sectional study.

Artificial intelligence (AI) and the introduction of Large Language Model (LLM) chatbots have become a common source of patient inquiry in healthcare. The quality and readability of AI-generated patient education materials (PEM) is the subject of many studies across multiple medical topics. Most demonstrate poor readability and acceptable quality. However, an area yet to be investigated is chemoth...

Leveraging Convolutional Neural Networks for Predicting Symptom Escalation in Chemotherapy Patients: A Temporal Resampling Approach.

This paper introduces a novel approach for predicting symptom escalation in chemotherapy patients by leveraging Convolutional Neural Networks (CNNs). Accurate forecasting of symptom escalation is crucial in cancer care, as it enables timely interventions and enhances symptom management, ultimately improving patients' quality of life during treatment. The analytical dataset consists of daily self-r...

Regulation of Dendritic Cell Function by Ermiaosan via the EP4-cAMP-CREB Signaling Pathway

Ermiao San (EMS), a traditional Chinese medicine composed of Atractylodes macrocephala and Cortex Phellodendron, has demonstrated therapeutic effica...

Cancer Vaccine Adjuvant Name Recognition from Biomedical Literature using Large Language Models

Motivation: An adjuvant is a chemical incorporated into vaccines that enhances their efficacy by improving the immune response. Identifying adjuvant...

Automatic quantification of breast cancer biomarkers from multiple 18F-FDG PET image segmentation

Neoadjuvant chemotherapy (NAC) has become a standard clinical practice for tumor downsizing in breast cancer with 18F-FDG Positron Emission Tomograp...

Computational modelling of cancer nanomedicine: Integrating hyperthermia treatment into a multiphase porous-media tumour model

Heat-based cancer treatment, so-called hyperthermia, can be used to destroy tumour cells directly or to make them more susceptible to chemotherapy o...

A Serial MRI-based Deep Learning Model to Predict Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma.

Purpose To develop and evaluate a deep learning-based prognostic model for predicting survival in locoregionally advanced nasopharyngeal carcinoma (LA...

A two-stage dual-task learning strategy for early prediction of pathological complete response to neoadjuvant chemotherapy for breast cancer using dynamic contrast-enhanced magnetic resonance images

Rationale and Objectives: Early prediction of pathological complete response (pCR) can facilitate personalized treatment for breast cancer patients....

Multivariate Feature Selection and Autoencoder Embeddings of Ovarian Cancer Clinical and Genetic Data

This study explores a data-driven approach to discovering novel clinical and genetic markers in ovarian cancer (OC). Two main analyses were performe...

Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic Settings.

PURPOSE: Necrosis quantification in the neoadjuvant setting using pathology slide review is the most important validated prognostic marker in conventi...

[Value of the deep learning automated quantification of tumor-stroma ratio in predicting efficacy and prognosis of neoadjuvant therapy for breast cancer based on residual cancer burden grading].

To investigate the prognostic value of deep learning-based automated quantification of tumor-stroma ratio (TSR) in patients undergoing neoadjuvant th...

Truthful mechanisms for linear bandit games with private contexts

The contextual bandit problem, where agents arrive sequentially with personal contexts and the system adapts its arm allocation decisions accordingl...

Guiding Treatment Strategies: The Role of Adjuvant Anti-Her2 Neu Therapy and Skin/Nipple Involvement in Local Recurrence-Free Survival in Breast Cancer Patients

This study explores how causal inference models, specifically the Linear Non-Gaussian Acyclic Model (LiNGAM), can extract causal relationships betwe...

Enhanced prediction of breast cancer patient response to chemotherapy by integrating deconvolved expression patterns of immune, stromal and tumor cells

The tumor microenvironment (TME) is a complex ecosystem of diverse cell types whose interactions govern tumor growth and clinical outcome. While multi...

Gene-Family Encoding Boosts Domain-Adapted Single-Cell Language Models

Transformer-based single-cell foundation models often rely on ranked-gene (RG) sequences where genes, ranked by expression, are often not functionally...

Efficacy and safety evaluation of artificial intelligence-identified antimicrobial peptides for use against avian pathogenic Escherichia coli in the poultry industry

The overuse of antibiotics in both veterinary and human medicine has resulted in the emergence of antibiotic-resistant bacteria, prompting a search fo...

Regularized Single-cell Imaging Enables Generalizable AI models for Stain-free Cell Viability Screening

Cell viability assays are essential tools in biomedical research and drug development. Artificial intelligence (AI) offers the potential to simplify t...

Phenotypic AI-based design of cell-specific small molecule cytotoxics

Drug discovery is being transformed by artificial intelligence, which enables the exploration of vast chemical spaces and the generation of novel comp...

Artificial intelligence-enabled automated analysis of transmission electron micrographs to evaluate chemotherapy impact on mitochondrial morphology in triple negative breast cancer

Advancements in transmission electron microscopy (TEM) have enabled in-depth studies of biological specimens, offering new avenues to large-scale imag...

DREAMER-S: Deep leaRning-Enabled Attention-based Multiple-instance approaches with Explainable Representations for Spatial biology

Identifying image features that associate strongly with diagnostic or prognostic classes in large-scale, multi-channel spatial imaging is challenging ...