Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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The daily dynamics of algorithmic pressure and traffic safety in gig delivery: a multilevel mediation model of risky riding.

The rapid expansion of on-demand food delivery has brought algorithmic management, the use of artificial intelligence to oversee labor processes, into everyday working life. The same system that maximizes operational efficiency may also place substantial psychosocial burdens on riders. This study examines the daily dynamics linking algorithmic performance pressure, risky riding behaviors, and near...

Sep 5 2026 42700555

Comparative evaluation of large language models for text-based diagnostic reasoning in fetal central nervous system MRI: A retrospective single-center diagnostic accuracy study.

Fetal magnetic resonance imaging (MRI) plays an important role in evaluating prenatal central nervous system (CNS) abnormalities, but expert interpretation and counseling remain challenging. Large language models (LLMs) may support text-based diagnostic reasoning, yet their performance in fetal CNS MRI has not been well characterized. The study aimed to compare ChatGPT, Gemini, and DeepSeek in tex...

Sep 4 2026 42700049
Personalized Oxygen Saturation Targets Compared to the Oxygen Saturation Experienced in Care Among Mechanically Ventilated Adults.

RATIONALE: For critically ill adults receiving invasive mechanical ventilation, randomized trials have found no significant average treatment effect o...

Sep 4 2026 42696412
Transforming large language models into medical specialists via knowledge injection.

While general-purpose large language models (LLMs) demonstrate remarkable capabilities, their clinical application demands rigorous adaptation to ensu...

Sep 4 2026 42697202
A five-phase evaluation framework for diagnostic and predictive medical artificial intelligence.

Artificial intelligence (AI) has advanced rapidly across diagnostic, prognostic, and clinical decision-support applications, yet the pathway from labo...

Sep 3 2026 42697954
Technology fatigue, cognitive load, and clinician well-being in modern anesthesia practice.

PURPOSE OF REVIEW: Medical devices like physiologic monitors, anesthesia machines, and ventilators, are designed by biomedical engineers but used by c...

Sep 3 2026 42689377
Physician Ratings and Adoption of AI-Generated e-Consultation Advice: A Randomized Clinical Vignette Study.

BACKGROUND: Medically specialized generative artificial intelligence (GAI) systems are increasingly used by clinicians as a form of electronic consult...

Sep 3 2026 42690592
Artificial Intelligence-Based Simulation to Improve Code Status Discussions Among Internal Medicine Residents: A Pilot Randomized Trial.

BACKGROUND: Code status discussions (CSDs) are essential in clinical practice yet training modalities are often resource-intensive and not widely avai...

Sep 3 2026 42690594
Scaffolded AI-Supported Problem-Based Learning for Medical Interns: Exploratory Retrospectively Registered Randomized Controlled Evaluation With a Voluntary Feasibility Follow-Up.

BACKGROUND: High-quality problem-based learning (PBL) during internship is resource-intensive and difficult to scale without consistent facilitation. ...

Sep 3 2026 42691464
The safety risks of roadside trees: An analysis of injury outcomes in vehicle-tree collisions.

Roadside trees represent the most frequently struck fixed object in fatal crashes in the United States and constitute a substantial safety concern, pa...

Sep 3 2026 42691938
World Federation of Orthodontists Global Guidance on patient instructions and emergency protocols: A consensus framework for safe, patient-centered orthodontic care.

Orthodontic treatment is delivered in increasingly diverse clinical and digital environments, yet outcomes continue to depend on patients' understandi...

Sep 3 2026 42692930
Translational Study of Using FOCM/TS Metabolites for Supporting Autism Spectrum Disorder Diagnosis.

PURPOSE: Several clinical trial studies have shown correlations between certain physiological measurements and an ASD diagnosis. Such findings, howeve...

Sep 3 2026 42693303
Artificial intelligence-guided engineering of precision ocular therapeutics.

PURPOSE OF REVIEW: This review surveys recent advances in artificial intelligence-guided small molecule discovery and gene therapy, with a focus on ge...

Sep 3 2026 42687624
PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [68Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy.

Lesions with a Prostate Imaging-Reporting and Data System (PI-RADS) score of 4 or greater on multiparametric MRI (mpMRI) indicate a high likelihood of...

Sep 2 2026 42315309
Evaluation of a cornea-specialized large language model for diagnostic and management accuracy in complex corneal cases.

PURPOSE: To evaluate whether a cornea-specialized large language model (LLM) enhanced with retrieval-augmented generation (RAG) improves clinicians' d...

Sep 2 2026 42684491
User Engagement and Feature Preferences in an AI-Powered mHealth Intervention for Diabetes Prevention: Secondary Analysis of a Randomized Controlled Trial.

BACKGROUND: Prediabetes is highly prevalent and increasing globally, yet lifestyle interventions remain underused. AI-driven mobile health (mHealth) t...

Sep 2 2026 42685343
Digital Twin-Enabled Toxicology: Current Applications, Opportunities, and Future Directions.

Toxicology has long depended on animal studies and static computational models to evaluate the safety of chemical substances and pharmaceutical compou...

Sep 2 2026 42686080
Bridging language markers and pathology: correlations between digital speech measures and surrogate CSF biomarkers in Alzheimer's disease.

INTRODUCTION: Digital language markers show promise in detecting early cognitive impairment related to Alzheimer's disease (AD), yet their relationshi...

Sep 2 2026 42688514
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