Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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An agentic AI system enhances clinical detection of immunotherapy toxicities: a multi-phase validation study

Immune-related adverse events (irAEs) affect up to 40% of patients receiving immune checkpoint inhib...

A Proof-of-Concept Study of a Clinical Decision Support System for Vancomycin Therapeutic Monitoring

Artificial intelligence (AI), particularly large language models (LLMs), is increasingly explored in...

Towards Policy-Adaptive Image Guardrail: Benchmark and Method

Accurate rejection of sensitive or harmful visual content, i.e., harmful image guardrail, is critica...

GuardAlign: Test-time Safety Alignment in Multimodal Large Language Models

Large vision-language models (LVLMs) have achieved remarkable progress in vision-language reasoning ...

Onco-Shikshak: An AI-Native Adaptive Learning Ecosystem for Medical Oncology Education

Medical oncology education faces a dual crisis: knowledge velocity that outpaces static curricula an...

Adversarial Robustness of Deep Learning-Based Thyroid Nodule Segmentation in Ultrasound

Introduction: Deep learning-based segmentation models are increasingly integrated into clinical imag...

When Safety Collides: Resolving Multi-Category Harmful Conflicts in Text-to-Image Diffusion via Adaptive Safety Guidance

Text-to-Image (T2I) diffusion models have demonstrated significant advancements in generating high-q...

Provably Safe Generative Sampling with Constricting Barrier Functions

Flow-based generative models, such as diffusion models and flow matching models, have achieved remar...

Evaluating the AI Potential as a Safety Net for Diagnosis: A Novel Benchmark of Large Language Models in Correcting Diagnostic Errors

Background: Diagnostic errors are a leading cause of preventable patient harm, often occurring durin...

When Safety Collides: Resolving Multi-Category Harmful Conflicts in Text-to-Image Diffusion via Adaptive Safety Guidance

Text-to-Image (T2I) diffusion models have demonstrated significant advancements in generating high-q...

HD-TTA: Hypothesis-Driven Test-Time Adaptation for Safer Brain Tumor Segmentation

Standard Test-Time Adaptation (TTA) methods typically treat inference as a blind optimization task, ...

Randomized Trial Protocol: Epic Generative AI Chart Summarization Tool to Reduce Ambulatory Provider Cognitive Task Load

Background: EHR documentation and chart review contribute to clinician workload and burnout. To alle...

Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale

Objective: Electronic Health Record (EHR)-based trial emulation can support translation of randomize...

Benchmarking Large Language Models for Predicting Therapeutic Antisense Oligonucleotide Efficacy

Antisense oligonucleotides (ASOs) are a promising class of therapeutic agents capable of selectively...

Near-Optimal Sample Complexity for Online Constrained MDPs

Safety is a fundamental challenge in reinforcement learning (RL), particularly in real-world applica...

Representation Before Retrieval: Structured Patient Artifacts Reduce Hallucination in Clinical AI Systems

Background: Large language models show promise for clinical decision support, yet their propensity f...

Efficient Streaming Algorithms for Two-Dimensional Congruence Testing and Geometric Hashing

The geometric congruence problem is a fundamental building block in many computer vision and image r...

TRACE: Temporal Reasoning via Agentic Context Evolution for Streaming Electronic Health Records (EHRs)

Large Language Models (LLMs) encode extensive medical knowledge but struggle to apply it reliably to...

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