Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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AI is Smart. Is it Wise? Quantifying the Effect of Patient-Choice (β) on Physical Outcomes

Large language models (LLMs) increasingly guide clinical decisions through population-level evidence, yet they cannot encode individual patient preferences. When treatments yield comparable outcomes, patient choice may drive decisions, though its effect remains unquantified. The Spine Patient Outcomes Research Trial (SPORT), marked by similar surgical and nonoperative results and substantial cross...

HomeSafe-Bench: Evaluating Vision-Language Models on Unsafe Action Detection for Embodied Agents in Household Scenarios

The rapid evolution of embodied agents has accelerated the deployment of household robots in real-world environments. However, unlike structured industrial settings, household spaces introduce unpredictable safety risks, where system limitations such as perception latency and lack of common sense knowledge can lead to dangerous errors. Current safety evaluations, often restricted to static images,...

Mar 12 2026 2603.11975v1
Ensuring Safety in Automated Mechanical Ventilation through Offline Reinforcement Learning and Digital Twin Verification

Mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory failure (ARF) in the ICU. However, inappropriate ventila...

Mar 11 2026 2603.11372v1
Co-designing a virtual reality based mindfulness application to address diabetes distress using Artificial Intelligence-informed Experience-Based Co-Design (AI-EBCD): a feasibility study

More than one third of adults with diabetes can experience diabetes distress due to the demands of daily self-care. As a cognitive therapy, mindfulnes...

More Signal vs. More Noise - Comparing Full Text and Abstract as Inputs for Large Language Model-based Classification of Oncology Trial Eligibility Criteria

Purpose: Large language models (LLMs) offer significant potential for automating the classification of clinical trials by eligibility criteria. Howeve...

A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic

Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Trans...

Mar 9 2026 2603.08448v2
Semantic Risk Scoring of Aggregated Metrics: An AI-Driven Approach for Healthcare Data Governance

Large healthcare institutions typically operate multiple business intelligence (BI) teams segmented by domain, including clinical performance, fundrai...

Mar 9 2026 2603.07924v1
A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic

Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Trans...

Mar 9 2026 2603.08448v1
Visual Self-Fulfilling Alignment: Shaping Safety-Oriented Personas via Threat-Related Images

Multimodal large language models (MLLMs) face safety misalignment, where visual inputs enable harmful outputs. To address this, existing methods requi...

Mar 9 2026 2603.08486v1
OD-RASE: Ontology-Driven Risk Assessment and Safety Enhancement for Autonomous Driving

Although autonomous driving systems demonstrate high perception performance, they still face limitations when handling rare situations or complex road...

Mar 6 2026 2603.05936v1
Efficacy of BodyMirror Clinical MS Multimodal Game-Based Digital Therapeutic for Remote Monitoring and Neurorehabilitation in Multiple Sclerosis: Protocol for a Multisite Randomised Controlled Trial

Multiple sclerosis (MS) is a chronic neurodegenerative disease characterised by progressive neurological disability and heterogeneous symptom trajecto...

Red-Teaming Medical AI: Systematic Adversarial Evaluation of LLM Safety Guardrails in Clinical Contexts

Background: Large language models (LLMs) are increasingly deployed in medical contexts as patient-facing assistants, providing medication information,...

Logi-PAR: Logic-Infused Patient Activity Recognition via Differentiable Rule

Patient Activity Recognition (PAR) in clinical settings uses activity data to improve safety and quality of care. Although significant progress has be...

Mar 5 2026 2603.05184v1
Show Your Work: Verbatim Evidence Requirements and Automated Assessment for Large Language Models in Biomedical Text Processing

Purpose: Large language models (LLMs) are used for biomedical text processing, but individual decisions are often hard to audit. We evaluated whether ...

Slice-wise quality assessment of high b-value breast DWI via deep learning-based artifact detection

Diffusion-weighted imaging (DWI) can support lesion detection and characterization in breast magnetic resonance imaging (MRI), however especially high...

Mar 4 2026 2603.03941v1
Design and Rationale of the My Heart Counts Cardiovascular Health Study: a Large-Scale, Fully Digital Biobank, and Randomized Trial of Large Language Model-Driven Coaching of Physical Activity

Background: Cardiovascular disease remains the leading cause of global morbidity and mortality. The original My Heart Counts smartphone application de...

MUSE: A Run-Centric Platform for Multimodal Unified Safety Evaluation of Large Language Models

Safety evaluation and red-teaming of large language models remain predominantly text-centric, and existing frameworks lack the infrastructure to syste...

Mar 3 2026 2603.02482v1
An Empirical Analysis of Calibration and Selective Prediction in Multimodal Clinical Condition Classification

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-...

Mar 3 2026 2603.02719v1
COOL-MC: Verifying and Explaining RL Policies for Platelet Inventory Management

Platelets expire within five days. Blood banks face uncertain daily demand and must balance ordering decisions between costly wastage from overstockin...

Mar 2 2026 2603.02396v1
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