Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Large-scale prediction of biological activities with Active-IT system.

Traditional testing methods in pharmaceutical development can be time-consuming and costly, but in silico evaluation tools can offer a solution. Our in-house Active-IT system, a Ligand-Based Virtual Screening (LBVS) tool, was developed to predict the biological and pharmacological activities of small organic molecules. It includes four independent modules for generating molecular descriptors (3D-P...

Dec 1 2024 39718107

Deciphering the Role of SLFN12: A Novel Biomarker for Predicting Immunotherapy Outcomes in Glioma Patients Through Artificial Intelligence.

Gliomas are the most prevalent form of primary brain tumours. Recently, targeting the PD-1 pathway with immunotherapies has shown promise as a novel glioma treatment. However, not all patients experience long-lasting benefits, underscoring the necessity to discover reliable biomarkers for predicting treatment outcomes. This study applied a range of advanced artificial intelligence methods to ident...

Dec 1 2024 39740094
Randomized-Grid Search for Hyperparameter Tuning in Decision Tree Model to Improve Performance of Cardiovascular Disease Classification

Cardiovascular disease refers to any critical condition that impacts the heart. Because heart diseases can be life-threatening. Researchers are focu...

When Image Generation Goes Wrong: A Safety Analysis of Stable Diffusion Models

Text-to-image models are increasingly popular and impactful, yet concerns regarding their safety and fairness remain. This study investigates the ab...

DD-PRiSM: a deep learning framework for decomposition and prediction of synergistic drug combinations.

Combination therapies have emerged as a promising approach for treating complex diseases, particularly cancer. However, predicting the efficacy and sa...

Nov 22 2024 39800875
Artificial Intelligence in Cardiovascular Clinical Trials.

Randomized clinical trials are the gold standard for establishing the efficacy and safety of cardiovascular therapies. However, current pivotal trials...

Nov 12 2024 39505413
Transforming Medical Regulations into Numbers: Vectorizing a Decade of Medical Device Regulatory Shifts in the USA, EU, and China

Navigating the regulatory frameworks that ensure the safety and efficacy of medical devices can be challenging, especially across different regions....

Artificial intelligence for optimizing recruitment and retention in clinical trials: a scoping review.

OBJECTIVE: The objective of our research is to conduct a comprehensive review that aims to systematically map, describe, and summarize the current uti...

Nov 1 2024 39259922
Artificial intelligence to improve clinical coding practice in Scandinavia: a crossover randomized controlled trial

\textbf{Trial design} Crossover randomized controlled trial. \textbf{Methods} An AI tool, Easy-ICD, was developed to assist clinical coders and was ...

Standardization Trends on Safety and Trustworthiness Technology for Advanced AI

Artificial Intelligence (AI) has rapidly evolved over the past decade and has advanced in areas such as language comprehension, image and video reco...

Deterministic complexity analysis of Hermitian eigenproblems

In this work we revisit the arithmetic and bit complexity of Hermitian eigenproblems. Recently, [BGVKS, FOCS 2020] proved that a (non-Hermitian) mat...

Vernacularizing Taxonomies of Harm is Essential for Operationalizing Holistic AI Safety

Operationalizing AI ethics and safety principles and frameworks is essential to realizing the potential benefits and mitigating potential harms caus...

Explainability of Point Cloud Neural Networks Using SMILE: Statistical Model-Agnostic Interpretability with Local Explanations

In today's world, the significance of explainable AI (XAI) is growing in robotics and point cloud applications, as the lack of transparency in decis...

Unlocking the Full Potential of High-Density Surface EMG: Novel Non-Invasive High-Yield Motor Unit Decomposition

The decomposition of high-density surface electromyography (HD-sEMG) signals into motor unit discharge patterns has become a powerful tool for inves...

Coherence-Driven Multimodal Safety Dialogue with Active Learning for Embodied Agents

When assisting people in daily tasks, robots need to accurately interpret visual cues and respond effectively in diverse safety-critical situations,...

Data-driven Design of Randomized Control Trials with Guaranteed Treatment Effects

Randomized controlled trials (RCTs) can be used to generate guarantees on treatment effects. However, RCTs often spend unnecessary resources explori...

Intramuscular High-Density Micro-Electrode Arrays Enable High-Precision Decoding and Mapping of Spinal Motor Neurons to Reveal Hand Control

Decoding nervous system activity is a key challenge in neuroscience and neural interfacing. In this study, we propose a novel neural decoding system...

Mapping Hong Kong's Financial Ecosystem: A Network Analysis of the SFC's Licensed Professionals and Institutions

We present the first study of the Public Register of Licensed Persons and Registered Institutions maintained by the Hong Kong Securities and Futures...

DISCO: A Hierarchical Disentangled Cognitive Diagnosis Framework for Interpretable Job Recommendation

The rapid development of online recruitment platforms has created unprecedented opportunities for job seekers while concurrently posing the signific...

Chain-of-Jailbreak Attack for Image Generation Models via Editing Step by Step

Text-based image generation models, such as Stable Diffusion and DALL-E 3, hold significant potential in content creation and publishing workflows, ...

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