Clinical Trials

Smartphone Applications in Dermatology With Special Focus on AI: A European-Continent-Based Review.

Smartphone applications for dermatology are widely available across Europe, yet evidence on their characteristics, validation, and regulatory compliance remains limited. This review, conducted by the European Academy of Dermatology and Venereology (EADV) Artificial Intelligence (AI) Task Force, systematically searched app stores in 44 European countries, identifying 1746 apps in 2024, of which 420...

Comment on: Enhancing patient education in cataract surgery using a conversational artificial intelligence chatbot: pilot randomized controlled trial.

Reply: Enhancing Patient Education in Cataract Surgery Using a Conversational Artificial Intelligence Chatbot: A Pilot Randomized Controlled Trial.

Development of a predictive marker panel for the individualised bDMARD therapy of psoriatic arthritis: protocol for a prospective observational study (Integrate-PsA).

INTRODUCTION: Psoriatic arthritis is a chronic inflammatory disease that can affect the axial skeleton as well as the joints and enthesis. Following t...

Clinical Study on the Prevention of High-Risk Pulmonary Nodule Progression With Yifei Sanjie Pill: Protocol for a Multicenter Randomized Controlled Trial.

BACKGROUND: High-risk subsolid pulmonary nodules, especially mixed ground-glass nodules, can represent precancerous or early-stage lung adenocarcinoma...

Metrics Used for the Evaluation of Chatbots Providing Cancer Genetic Risk Assessment and Education: Systematic Review.

BACKGROUND: Chatbots have recently emerged as an alternative approach for delivering cancer risk assessment and genetic counseling. Understanding the ...

Application of AI in Hypertension Health Education: Scoping Review.

BACKGROUND: Hypertension is a major global health challenge, and effective health education is crucial for improving patients' self-management. Tradit...

Performance Gaps and Optimization Strategies in Chinese Medical Large Language Models Based on MedBench: Evaluation Study.

BACKGROUND: The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensur...

CMTM3 links inflammation-related transcriptional dysregulation to immune and therapeutic stratification in gastric cancer.

Gastric cancer (GC) shows strong biological heterogeneity and frequent disruption of inflammatory and metabolic programs, which affect tumor progressi...

Precision-Driven Management of Great Saphenous Varicose Veins: A Narrative Review.

OBJECTIVES: Great saphenous vein (GSV) incompetence is common, but numerous treatment options complicate patient-treatment matching. This narrative re...

Scientific evidence of commercial artificial intelligence products for pulmonary nodule assessment on CT scans: a systematic review.

OBJECTIVES: This systematic review evaluates the available evidence on the efficacy of commercially available AI-software applications for lung nodule...

Transcranial photobiomodulation improves prefrontal oxygenation and impulse control in adults with ADHD: a randomized controlled trial.

BACKGROUND: Impulsivity in individuals with attention-deficit/hyperactivity disorder (ADHD) diminishes quality of life. Cortical hypometabolism has be...

Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix.

BACKGROUND: Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB...

Nonverbal AI-Based Communication Robot for Staff in Disaster-Affected Care Facilities: Exploratory ABAB Intervention Study.

BACKGROUND: Medical and welfare facilities in the Noto region of Japan were severely affected by the 2024 Noto Peninsula earthquake and subsequent tor...

Use of an AI Image Recognition-Based Smartphone App in Personalized Bowel Preparation Before Colonoscopy: Prospective Randomized Controlled Trial.

BACKGROUND: Sufficient bowel preparation is critical for increasing the quality of colonoscopy. However, current bowel preparation guidelines have lim...

AI-Generated Microlearning for Plastic Surgery Residency: Single-Arm Pre-Post Feasibility Study.

BACKGROUND: Surgical residency training faces mounting pressure from expanding subspecialty knowledge requirements alongside compressed learning oppor...

An Interactive Virtual Nephrologist to Engage Patients With Advanced CKD About Transplantation.

RATIONALE & OBJECTIVE: Despite advantages in survival and quality of life with kidney transplantation (KT) compared to other treatments for kidney fai...

Qualitative investigation into the rural and coastal workforce for allied health professional leaders in England.

BACKGROUND: Allied Health Professional (AHP) services in England assess, diagnose, treat and rehabilitate patients across a wide range of health and c...

Safety boundary maintenance in consumer AI systems responding to pediatric health queries: a cross-platform benchmark evaluation under naturalistic and adversarially pressured conditions.

Consumer artificial intelligence chatbots are now accessed by hundreds of millions of users seeking health information, yet systematic evaluation of t...

Comparative Evaluation of Locally Delivered Aloe vera Gel as an Adjunct to Scaling and Root Planing in Patients With Periodontitis: A Randomized Clinical Trial.

BACKGROUND: Herbal adjuncts have gained increasing interest in nonsurgical periodontal therapy because of their anti-inflammatory, antimicrobial, and ...