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Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Accuracy, Readability, and Clinical Applicability of AI-Generated Breastfeeding Education Brochures: A Mixed-Methods Evaluation.

BACKGROUND: Generative artificial intelligence (AI) is increasingly used in health communication and nursing education; however, its clinical reliability remains uncertain. Breastfeeding education requires accurate, readable, and clinically applicable materials. AIM: The purpose of this explanatory sequential mixed-methods study was to evaluate AI-generated breastfeeding education brochures in ter...

May 19 2026 42157505

Multicenter validation and randomized crossover reader evaluation of deep learning-assisted tri-sequence three-dimensional MRI segmentation for hypopharyngeal tumor.

BACKGROUND AND PURPOSE: Accurate MRI-based target delineation for hypopharyngeal squamous cell carcinoma (HPSCC) is clinically important but expertise dependent. We aimed to develop a multicenter-validated tri-sequence deep-learning model, determine whether AI assistance narrows contouring expertise gap, and explore quality-aware low-overlap risk modeling to inform deployment support. MATERIALS AN...

May 19 2026 42162744
A clinically interpretable deep learning pipeline for diabetic retinopathy classification using EfficientNet, advanced data augmentation and GradCAM.

BACKGROUND: Early and reliable grading of diabetic retinopathy is important for preventing avoidable vision loss. Although deep learning methods have ...

May 19 2026 42151890
CNS-Obsidian: A Neurosurgical Vision-Language Model Built From Scientific Publications.

BACKGROUND AND OBJECTIVES: General purpose vision-language models (VLMs) demonstrate impressive capabilities, but their opaque training on uncurated i...

May 19 2026 42153721
AI-guided integration of aging-related functional assessment to predict nonresponse to cardiac rehabilitation in heart failure.

BACKGROUND: Cardiac rehabilitation (CR) improves functional capacity and outcomes in patients with heart failure (HF). However, a clinically significa...

May 19 2026 42155949
Automated Safety Testing and Reporting Application for Conversational Safety Monitoring of Generative AI Tools for Mental Health: Development and Validation Study.

BACKGROUND: Artificial intelligence (AI)-based conversational tools are rapidly expanding within mental health care as a means of increasing access an...

May 19 2026 42155999
Randomised Controlled Multicentre Trial to Investigate the Effectiveness of a Mobile Artificial Intelligence Solution for Diabetes Adapted Care: The MELISSA Trial Protocol.

AIMS: Achieving optimal glycaemic control remains a burden for many people with diabetes on intensive insulin treatment. The MELISSA trial aims to cli...

May 19 2026 42156180
Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study.

Personalized data-driven interventions for depression are much needed. Here, we leveraged N-of-1 machine learning (ML) to optimally target behavioral ...

May 19 2026 42151558
Artificial intelligence-assisted integrated care to promote colonoscopy uptakeĀ (AICC) in China: study protocol for a cluster randomized controlled trial.

BACKGROUND: Colorectal cancer (CRC) leads to heavy disease and economic burdens globally. Early screening such as colonoscopy has been demonstrated to...

May 18 2026 42152022
Application of artificial intelligence-assisted education for postoperative pulmonary rehabilitation: a hybrid model of AI and nurse-driven support.

OBJECTIVE: To explore the clinical value of AI-assisted pulmonary rehabilitation education in patients undergoing thoracoscopic surgery for lung cance...

May 18 2026 42152114
Multimodal Personalized Mobile Health Just-in-Time Adaptive Intervention for Occupational Stress Management: Pilot Study.

BACKGROUND: As digital health solutions gain traction, there is an urgent need for effective, person-centered stress management tools for employees. A...

May 18 2026 42150167
Research on strategies for enhancing the competency of safety directors in EPC projects empowered by AI.

With the widespread application of the engineering-procurement-construction (EPC) delivery model in large-scale infrastructure and complex industrial ...

May 18 2026 42149887
Predictors of the Efficacy of Focused Ultrasound for Moderate-to-Severe Persistent Allergic Rhinitis: A Retrospective Cohort Study.

BACKGROUND: Focused ultrasound (FUS) has achieved favorable results in the treatment of allergic rhinitis (AR). However, some patients still have poor...

May 17 2026 42144291
Highly Efficient Broad-Spectrum Antibacterial Carbon Dots through Hierarchical Machine Learning Framework.

The global threat of antibiotic resistance necessitates intelligent design strategies for next-generation antibacterial nanomaterials. Herein, high-ef...

May 16 2026 42142065
Comparative study on the efficacy of large language models (LLMs) in health management for patients with urological and andrological diseases: a multidimensional quality evaluation and applicability analysis.

PURPOSE: This study aims to evaluate the efficacy of large language models (LLMs) in health management for urological and andrological conditions by c...

May 16 2026 42142252
Enhancing spectral analysis of ghee adulteration via a deep learning-based multimodal attention mechanism.

Expensive dairy products like ghee are at high risk of hazardous adulteration with cheaper fats, and traditional testing approaches such as FTIR devic...

May 16 2026 42143095
In vitro evaluation of automated single-unit crown design using artificial intelligence: Design time, marginal misfit, dental morphology, and contact points.

OBJECTIVE: To compare an artificial intelligence-based design workflow with a manual CAD workflow in terms of design time, vertical marginal misfit, d...

May 15 2026 42142614
Efficacy and safety evaluation of artificial intelligence-identified antimicrobial peptides targeting avian pathogenic Escherichia coli in broiler chickens.

BACKGROUND: The overuse of antibiotics in both veterinary and human medicine has resulted in the emergence of antibiotic-resistant bacteria, prompting...

May 15 2026 42135842
Artificial Intelligence-Enhanced Identification of Incidental Findings in Prostate MRI.

OBJECTIVES: The use of prostate magnetic resonance imaging (MRI) is increasing, and coverage often captures substantial portions of the pelvis, visual...

May 15 2026 42136201
Toward protocol simplification: Deep learning-based image synthesis in three-phase CT urography.

OBJECTIVE: The purpose of this study was to develop and evaluate a method for synthesizing 3D urothelial phase images in CTU examinations from the dua...

May 15 2026 42140070
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