Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Application of artificial intelligence in schizophrenia rehabilitation management: a systematic scoping review.

Artificial intelligence (AI) is increasingly used in mental health, yet its rehabilitation-oriented applications in schizophrenia have not been systematically mapped. We conducted a systematic scoping review of PubMed, Web of Science, IEEE Xplore and the ACM Digital Library (January 1, 2012-October 31, 2025; two search rounds), applying operationalized rehabilitation boundaries and excluding diagn...

Mar 9 2026 41803101

Harnessing the Power of artificial intelligence for clinical trials in cancer.

INTRODUCTION: Cancer research has become increasingly data-intensive, with digital pathology, imaging, and genomic sequencing generating vast, heterogeneous datasets. Artificial intelligence (AI) now plays a growing role across the oncology continuum, offering tools to interpret complex data, streamline workflows, and enhance clinical decision-making. In the context of clinical trials, AI is emerg...

Mar 9 2026 41797434
Deep Brain Stimulation Induces Antidepressant Effects by Restoring High-Fidelity Communication in the BNST-NAc Circuit.

Deep brain stimulation (DBS) for treatment-resistant depression (TRD) is challenged by significant individual variability in efficacy and unclear neur...

Mar 9 2026 41801046
Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.

BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lackin...

Mar 9 2026 41801173
Effectiveness of meditation in the management of epilepsy: An updated mini systematic review of recent findings.

BACKGROUND: Epilepsy is a chronic neurological disorder characterized by altered cortical excitability. The disorder is often associated with psycholo...

Mar 8 2026 41806957
Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence-enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative.

BACKGROUND: There is an urgent need to evaluate the efficacy of novel therapeutics that have been approved for use in adults with IgA nephropathy (IgA...

Mar 8 2026 41795009
Tumor burden in metastatic colorectal cancer quantified using deep learning models: Prognostic value and maintenance treatment benefit in the CAIRO3 trial.

INTRODUCTION: Total tumor number (TTN) and total tumor volume (TTV) reflect tumor burden and have been linked to outcomes in metastatic colorectal can...

Mar 7 2026 41819026
Pharmacokinetic modeling to optimize development and therapeutic potential of mAb-based therapies.

Monoclonal antibody (mAb)-based therapies have revolutionized modern medicine, offering highly specific and effective treatments for a wide range of d...

Mar 6 2026 41796750
The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review).

The interaction between autophagy and ferroptosis has resulted in the identification of novel approaches for the treatment of lung cancer (LC). The tw...

Mar 6 2026 41789644
Triage Nurses' Perceptions of Artificial Intelligence: A Cross-Sectional Study.

INTRODUCTION: Emergency department crowding and increasing patient complexity challenge traditional triage models. Artificial intelligence may support...

Mar 6 2026 41793396
From pharmacokinetic genes to polygenic scores and multi-omic integration: advances towards precision psychiatry.

INTRODUCTION: . Pharmacological treatment is the mainstay in the acute and long-term management of severe mental disorders such as major depressive di...

Mar 6 2026 41789450
Assessing the clinical competence of large language models for tobacco use disorder: A multi-domain expert evaluation.

BACKGROUND: Tobacco use disorder (TUD) remains the leading preventable cause of death globally, yet fewer than one-third of users receive guideline-co...

Mar 6 2026 41789824
Development of a Classifier for Metabolic Subtypes of Nasopharyngeal Carcinoma to Guide Personalized Immunotherapy Strategies: Biomarker Analysis of the Phase III CONTINUUM and DIPPER Trials.

PURPOSE: Personalized immunotherapy strategies are urgently needed for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We aim to...

Mar 6 2026 41791006
Strategies to Improve the Stability and Translation of Therapeutic mRNAs.

Therapeutic messenger RNAs (mRNAs) offer a versatile platform for treating a wide range of diseases, but their clinical efficacy hinges on optimizing ...

Mar 6 2026 41791406
AI-guided surgical decision support system for corneal laceration repair: a prospective, non-randomized controlled feasibility study.

To evaluate the feasibility and application value of a transfer learning-based artificial intelligence (AI) system for wound recognition and suture po...

Mar 6 2026 41792236
Development, application and evaluation of an artificial intelligence (AI)-based platform (SurgSmart) for the automatic assessment of the critical view of safety (CVS) in laparoscopic cholecystectomy (LC).

BACKGROUND: Laparoscopic Cholecystectomy (LC) is the standard surgical treatment for symptomatic benign gallbladder diseases. Bile Duct Injury (BDI) i...

Mar 6 2026 41792491
Clinical application progress and prospects of non-invasive preimplantation genetic testing (niPGT): A review.

Preimplantation genetic testing (PGT) is a critical tool in reproductive medicine for selecting genetically healthy embryos, thereby reducing the risk...

Mar 5 2026 41794367
Reframing the Performance and Ethics of Empathic AI: Wisdom of the Crowd and Placebos.

Recently, claims have emerged that artificial intelligence (AI) is better at providing empathy than humans. These claims are based on experiments in w...

Mar 5 2026 41785327
Artificial Intelligence in Drug Discovery and Development: Raising Quality per Decision.

Drug research and development continuously encounters prolonged timelines, escalating costs, and high attrition rates. In this narrative review, we in...

Mar 5 2026 41786310
Human-in-the-loop validation of an artificial intelligence-driven real-time prostatic capsule recognition model for nerve-sparing robot-assisted radical prostatectomy.

BACKGROUND: Nerve-sparing robot-assisted radical prostatectomy (NS-RARP) requires precise prostatic capsule identification to balance oncological cont...

Mar 5 2026 41787080
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