Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Evaluating Biomedical Feature Fusion on Machine Learning's Predictability and Interpretability of COVID-19 Severity Types: Model Development, Interpretation, and Validation.

BACKGROUND: Accurately differentiating severe from nonsevere COVID-19 clinical types is critical for the health care system to optimize workflow. Current techniques lack the ability to accurately classify COVID-19 clinical types in patients, especially as SARS-CoV-2 continues to mutate. OBJECTIVE: We explore the predictability and interpretability of multiple state-of-the-art machine learning (ML)...

Apr 30 2026 42060527

Improving Long-Term Adherence to Endocrine Therapy Among Breast Cancer Survivors: Development of a Multiscale Modeling and Intervention System.

BACKGROUND: Breast cancer is a significant public health burden. Despite its critical role in preventing the recurrence of breast cancer, rates of long-term adherence to endocrine therapy (ET) remain low among certain breast cancer survivors. Using embedded sensors in smartphones and wearables, ecological momentary assessment data and health behavior theory may facilitate a richer understanding of...

Apr 30 2026 42060540
Current Landscape of Mental Health Conversational Agents From a Trauma-Informed Care Lens: Scoping Review.

BACKGROUND: Conversational agents (CAs) are increasingly used in mental health care to enhance access and engagement. However, their safe, ethical, an...

Apr 30 2026 42061294
A quantitative analysis of global AI medical studies: gaps in randomized controlled trials.

Medical artificial intelligence (AI) has advanced rapidly, yet a comprehensive quantitative overview of its clinical evaluation landscape remains lack...

Apr 30 2026 42062529
Modeling the relationship between residents' happiness and human settlement quality: An IGSA-MLPNN-GARSON approach.

Understanding how the quality of human settlements affects residents' happiness is crucial for sustainable urban planning during rapid urbanization. T...

Apr 30 2026 42060589
Anti-vascular endothelial growth factor therapy for posterior segment diseases: Progress, challenges, and the road ahead.

The emergence of anti-vascular endothelial growth factor (anti-VEGF) therapy has marked a paradigm shift in the treatment of retinal and choroidal vas...

Apr 29 2026 42060357
Artificial intelligence-driven donor-recipient gut microbiome matching for optimized fecal microbiota transplantation.

Fecal microbiota transplantation (FMT) has emerged as a promising therapy for gastrointestinal diseases, yet its clinical efficacy remains individuall...

Apr 29 2026 42061404
Recurrent Processing Dynamics in Occluded Object Recognition Revealed by Electroencephalography and Deep Neural Networks.

The human visual system excels at recognizing occluded objects, yet the temporal dynamics of recurrent processing in this task remain unclear. Using h...

Apr 29 2026 42052812
Ambient AI Scribes to Create Educational Feedback Notes for Medical Students: A Randomized Trial.

BACKGROUND: High-quality observation and feedback contribute to the development of clinical competence and professional growth in medical education. F...

Apr 29 2026 42052923
Human-AI collaboration in clinical reasoning: a UK replication and interaction analysis.

OBJECTIVES: A paper from Goh et al. found that a large language model (LLM) working alone outperformed American clinicians assisted by the same LLM in...

Apr 29 2026 42053372
Errors in AI-Transformed Patient-Centered Mental Health Documentation Written by Psychiatrists: Qualitative Pre-Post Study.

BACKGROUND: Patients' digital access to their personal health data is becoming increasingly common worldwide. However, medical documentation often con...

Apr 29 2026 42054574
Random Survival Forest Versus Elastic-Net Regularized Cox Regression for Survival Prediction in Acute Myeloid Leukemia at Distinct Treatment Time Points: Model Performance Comparison Study.

BACKGROUND: Risk group stratification based on the prediction of survival of patients with acute myeloid leukemia (AML) is complex. Despite common ris...

Apr 29 2026 42054649
Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression.

INTRODUCTION: Sarcoidosis is a heterogeneous granulomatous disease with highly variable clinical trajectories, yet no validated biomarkers exist to di...

Apr 29 2026 42055611
Performance of artificial intelligence software: EndoAngel, EndoAID, CAD-EYE, GI Genius, and EndoScreener in adenoma detection: an extended network meta-analysis.

BACKGROUND: Colorectal cancer is a major global health burden, with most cases arising from adenomatous polyps. Although colonoscopy is the gold stand...

Apr 28 2026 42066011
The application of digital technology in nursing quality management: a scoping review.

BACKGROUND: Digital technology integrates information and communication tools such as electronic health records, wearable devices, and artificial inte...

Apr 28 2026 42050601
Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study.

Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in metastatic castration-sensitive prostate canc...

Apr 28 2026 42050823
Algorithmic insights: How FDI sources, digital financial inclusion, and geopolitics collide in Pakistan's environmental landscape.

The environmental effect of foreign direct investment is a much-discussed topic. Nevertheless, how foreign direct investment's country of origin can a...

Apr 28 2026 42054922
Effects of a Soft Robotic Exoskeleton for Gait Training on Clinical Outcomes in Patients With Parkinson Disease: Randomized Controlled Pilot Study.

BACKGROUND: Balance and gait disorders in Parkinson disease (PD) impair motor function and quality of life. OBJECTIVE: Evidence on soft exoskeleton ro...

Apr 28 2026 42048524
Safety-oriented and explainable machine learning for KSI crash risk prediction: Evidence from the United Kingdom.

Road traffic crashes pose a serious public safety challenge, particularly due to fatal and serious injuries. Although machine learning (ML) has been w...

Apr 28 2026 42048420
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