Clinical Trials

Development of a Classifier for Metabolic Subtypes of Nasopharyngeal Carcinoma to Guide Personalized Immunotherapy Strategies: Biomarker Analysis of the Phase III CONTINUUM and DIPPER Trials.

PURPOSE: Personalized immunotherapy strategies are urgently needed for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We aim to identify biomarkers predictive of immunotherapy benefits, using data from the phase III CONTINUUM (ClinicalTrials.gov identifier: NCT03700476) and DIPPER (ClinicalTrials.gov identifier: NCT03427827) randomized clinical trials. PATIENTS AND METHODS: ...

Strategies to Improve the Stability and Translation of Therapeutic mRNAs.

Therapeutic messenger RNAs (mRNAs) offer a versatile platform for treating a wide range of diseases, but their clinical efficacy hinges on optimizing both stability and translational efficiency. This review summarizes recent advances in strategies to enhance mRNA performance, with a focus on human therapeutics. We discuss secondary structure optimization, including artificial intelligence-guided d...

AI-guided surgical decision support system for corneal laceration repair: a prospective, non-randomized controlled feasibility study.

To evaluate the feasibility and application value of a transfer learning-based artificial intelligence (AI) system for wound recognition and suture po...

Development, application and evaluation of an artificial intelligence (AI)-based platform (SurgSmart) for the automatic assessment of the critical view of safety (CVS) in laparoscopic cholecystectomy (LC).

BACKGROUND: Laparoscopic Cholecystectomy (LC) is the standard surgical treatment for symptomatic benign gallbladder diseases. Bile Duct Injury (BDI) i...

Clinical application progress and prospects of non-invasive preimplantation genetic testing (niPGT): A review.

Preimplantation genetic testing (PGT) is a critical tool in reproductive medicine for selecting genetically healthy embryos, thereby reducing the risk...

Reframing the Performance and Ethics of Empathic AI: Wisdom of the Crowd and Placebos.

Recently, claims have emerged that artificial intelligence (AI) is better at providing empathy than humans. These claims are based on experiments in w...

Artificial Intelligence in Drug Discovery and Development: Raising Quality per Decision.

Drug research and development continuously encounters prolonged timelines, escalating costs, and high attrition rates. In this narrative review, we in...

Human-in-the-loop validation of an artificial intelligence-driven real-time prostatic capsule recognition model for nerve-sparing robot-assisted radical prostatectomy.

BACKGROUND: Nerve-sparing robot-assisted radical prostatectomy (NS-RARP) requires precise prostatic capsule identification to balance oncological cont...

Artificial intelligence in oral and maxillofacial surgery: a scoping review of clinical applications, ethical challenges, and legal considerations.

Artificial intelligence (AI) is increasingly used in oral and maxillofacial surgery (OMS) for imaging, planning, and robotic/navigation support, yet e...

Real-World Testing of an Artificial Intelligence Conversational Agent as an Early Intervention and Support Tool in the Mental Health Referral Care Pathway: A Mixed-Methods Study.

BACKGROUND: The incidence of mental health concerns is growing, and demand for support is exceeding service capacity. Digital tools can provide additi...

Intelligent model for stratification of acute radiation syndrome severity in humans.

PURPOSE: The aim of this study was to develop and compare two intelligent model for stratifying the severity of acute radiation syndrome (ARS) in huma...

AI-Driven Analysis of Cardiopulmonary Exercise Tests to Identify Gas Exchange and Ventilatory Thresholds.

BACKGROUND: A cardiopulmonary exercise test (CPET) provides the estimated lactate threshold (θLT) and respiratory compensation point (RCP) through vis...

How Service Robot Anthropomorphism and Employee Self-Efficacy Shape Collaborative Performance.

This study aims to elucidate the mechanisms through which service robot anthropomorphism and employee self-efficacy influence human-robot collaborativ...

Digital support systems to improve child development in Peru: A cluster-randomized controlled open-label trial.

Digital technologies have the potential to transform early childhood development (ECD) interventions by delivering personalized support at scale. We c...

Artificial Intelligence Predicted OSDAs Enable Direct Synthesis of Interlayer-Expanded Zeolites.

Zeolite crystallization is a metastable process under harsh conditions with poorly understood mechanisms, making the directed synthesis of specific fr...

Selective Sensing of Hydrogen and Ammonia Using a Single CMOS-Compatible Sensor and Transfer Learning Methods.

The development of high-performance gas sensors is crucial for ensuring safety and efficiency in the emerging hydrogen economy, particularly for detec...

Digital breast tomosynthesis and reading with artificial intelligence.

Digital breast tomosynthesis (DBT) increases sensitivity and specificity compared to digital mammography (DM) in the early detection of breast cancer....

AI Triage in Primary Care: Building Safer and More Equitable Real-World Evidence.

Artificial intelligence triage in general practice is developing rapidly within the primary care digital transformation, promising efficiency gains an...

Comparison of Atheroma Burden Changes Using Conventional vs. End-Diastolic Intravascular Ultrasound Segmentation　- Post Hoc Analysis of the PACMAN-AMI Study.

BACKGROUND: This study compared changes in percentage atheroma volume (PAV) using an end-diastolic (ED) intravascular ultrasound (IVUS) segmentation a...

CTP-Free Method for Automated Lesion Water Uptake in Acute Ischemic Stroke.

BACKGROUND AND PURPOSE: Net water uptake (NWU) in the infarct core of patients with ischemic stroke has been correlated with clinical outcome and lesi...