Clinical Trials

The impact of childhood trauma on brain structural connectivity in adolescent major depressive disorder: A graph-based analysis.

BACKGROUND: Childhood trauma (CT) significantly increases vulnerability to adolescent major depressive disorder (MDD), yet the underlying neurobiological mechanisms remain unclear. METHODS: This study applied graph-theoretical analysis to structural MRI data to examine how CT influences brain structural networks and antidepressant treatment outcomes in adolescent MDD. A total of 339 adolescents wi...

Performance evaluation of large language models in real-world perinatal medication consultations: a cross-sectional study.

INTRODUCTION: Perinatal medication consultation is a core clinical pharmacy service that involves a complex benefit-risk assessment for both maternal and fetal safety. Large language models (LLMs) have emerged as potential tools to improve access to medication information, yet their performance and safety in real-world, pharmacist-led perinatal consultation settings, particularly in non-English co...

Artificial intelligence and computerized decision support in adult intensive care: A systematic review of randomized controlled trials.

BACKGROUND: Artificial intelligence (AI) and computerized clinical decision support systems (CDSS) are increasingly applied in intensive care, yet the...

Does Sequential Use of Multiple Chatbots Influence Emergency Guidance for Dental Avulsion?

BACKGROUND/AIM: Artificial intelligence-based chatbot systems are increasingly used for dental emergency guidance, yet the clinical value of sequentia...

The Efficacy of Proprioceptive Neuromuscular Facilitation-Based Robot-Assisted Therapy in Individuals With Stroke: A Randomized Controlled Trial.

OBJECTIVES: The effects of combining robot-assisted therapy (RAT) with other physiotherapy approaches in stroke rehabilitation are of current interest...

Generative artificial intelligence use in medical research: A medical student vs. physician survey from Saudi Arabia.

INTRODUCTION: Generative artificial intelligence (GenAI) such as ChatGPT, is increasingly used to generate research ideas, aid in literature reviews, ...

Ai-enhanced clinical decision support reduces medication errors and adverse drug events in a multicenter teaching hospital network: A prospective randomized controlled trial.

BACKGROUND: Medication errors remain a leading source of preventable harm in hospitalized patients, contributing to adverse drug events (ADEs), prolon...

Intelligent virtual agents in psychotherapy: a safety evaluation across high-risk mental health scenarios.

The growing burden of mental illness and limited access to evidence-based psychotherapy have increased interest in artificial intelligence (AI)-driven...

Tech That Scales: A Practical Framework for Artificial Intelligence-Enabled Cancer Care in Low- and Middle-Income Countries and Underserved US Counties.

Cancer outcomes remain starkly unequal: 5-year survival rates for common malignancies in low- and middle-income countries (LMICs) often lag 20-40 perc...

Artificial Intelligence in Minimally Invasive Gynecological Surgery: A Systematic Review of Task- Specific Performance and Clinical Translational Readiness.

OBJECTIVE: To systematically evaluate the task-specific performance and clinical translational readiness of artificial intelligence (AI) applications ...

A relational agent for treating substance use in adults: A randomized controlled trial with a psychoeducational comparator.

BACKGROUND: Highly accessible and scalable, digital mental health interventions can reduce barriers associated with traditional treatment. Woebot for ...

First step towards predicting clinical immunogenicity of biologics using in vitro based readouts as animal trial alternatives.

Immunogenicity risk assessment is a critical step in the therapeutic development process of biologics. However, anti-drug antibodies continue to occur...

Examining interactive AI-supported learning environments: The mediating role of AI metacognition and the moderating role of cognitive flexibility.

As generative artificial intelligence (GenAI) becomes increasingly integrated into educational contexts, learners' interactions with AI systems have e...

Present and Future Post-marketing Drug Safety Assessment in Japan: A PMDA Perspective.

For pharmacovigilance, the Pharmaceuticals and Medical Devices Agency in Japan has utilized real world data (RWD) from multiple sources, including ind...

Unpacking the dual psychological paths of employee-AI collaboration on creativity: The role of proactive behavior.

The deep integration of artificial intelligence (AI) into organizational settings has significantly transformed employees' work patterns, underscoring...

The ABCD of AI-Enabled Clinical Reasoning: A Guided Framework to Transform Learner Interactions and Decision Quality.

OBJECTIVE: To evaluate the efficacy of a structured guidance framework articulate, brainstorm and benchmark, critique and customize, and decide and di...

AI-driven navigated hematoma aspiration vs. conservative treatment for spontaneous intracerebral hemorrhage: study protocol for a randomized controlled trial.

BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) remains one of the most devastating types of stroke, with high mortality and long-term disabili...

Current evidence and future directions for prophylactic anticoagulation therapy after severe spontaneous intracerebral hemorrhage: a narrative review.

Patients with spontaneous intracerebral hemorrhage (sICH) are at high risk for venous thromboembolism (VTE), a complication strongly associated with a...

Smart PPE and wearable technology for construction safety management: A scientometric analysis and state-of-the-art review.

This study presents a scientometric and state-of-the-art review of smart personal protective equipment (PPE) and wearable safety technologies (WSTs) i...

Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial.

BACKGROUND: Given the increasing prevalence of depression and anxiety disorders and enduring barriers to care, there is a critical need for alternativ...