Clinical Trials

Evaluating a negotiation training program for family caregivers of older people using a Multiphase Optimization Strategy (MOST) design and protocol.

UNLABELLED: Traditional clinical trial designs such as the isolated two-arm randomized controlled trial (RCT) do not offer robust solutions for evaluating and optimizing delivery of complex, multi-component behavioral interventions. A recent alternative design, the Multiphase Optimization Strategy (MOST), addresses many shortcomings of the isolated two-arm RCT. The MOST framework for trial design ...

Preliminary insights into artificial intelligence guided dosing in hypertension and diabetes: challenges and lessons learnt in a pilot feasibility study.

OBJECTIVE: CURATE.AI is an artificial intelligence platform enabling personalised drug dosing. Aims:1) Determine the feasibility of using CURATE.AI in the outpatient setting.2) Compare the consistency of CURATE.AI recommendations derived from different data sources.3) Assess the alignment of physician and CURATE.AI dosing recommendations. MATERIALS AND METHODS: We conducted a single-arm feasibilit...

Guidelines needed for the use of AI in the preparation or review of IRB, IBC, and IACUC applications.

Three oversight bodies review research proposals to help ensure the safe and responsible conduct of biomedical research, each focusing on unique aspec...

Workflow-embedded AI as a cognitive scaffold: A randomized trial on knowledge retention and diagnostic competency in undergraduate radiology education.

BACKGROUND: Traditional didactic methods in medical imaging education, predominantly reliant on static images (non-augmented, traditional PACS workflo...

Sleep apnoea and its consequences: from animal models to precision medicine.

A European Respiratory Society research seminar entitled "Sleep Apnoea and Its Consequences: From Animal Models to Precision Medicine" was held in Jan...

Effects of a transformer-based AI-based application to support incontinence-associated dermatitis and pressure injury assessment, nursing care and documentation: Controlled pilot intervention study.

BACKGROUND: Artificial intelligence (AI) is playing an increasingly important role in nursing care, including wound management. Differentiating pressu...

Relationship between artificial intelligence tool usage experience and academic stress among college students: Mediating role of loneliness and moderating role of academic self-efficacy.

As artificial intelligence (AI) rapidly integrates into higher education, AI tools are increasingly being utilized to support student learning. Althou...

Clinical pain increased with older brain age, yet placebo effects were preserved.

Chronic pain is linked to accelerated brain aging, often measured through the brain-age gap (BAG), the difference between chronological age and neuroi...

Developing an artificial intelligence-powered question-and-answer chatbot with English-Spanish capabilities for new mothers.

OBJECTIVES: Generative AI chatbots are revolutionizing health education by making complex information more accessible to the public. However, their us...

Multi-scale EEG analysis identifies neural circuit signatures of iTBS responsiveness in major depressive disorder.

BACKGROUND: Response to transcranial magnetic stimulation (TMS) in major depressive disorder (MDD) is highly variable, underscoring the need for bioma...

Altered gut microbiome function in ADHD: More Prevotella, less vitamin B12 biosynthesis, and beneficial modulation by synbiotic treatment.

The effect of psychostimulant medication in ADHD on the gut microbiome remains unknown. Oral Synbiotic 2000, comprising multiple lactic acid bacteria ...

Design and rationale of the WARRIOR ancillary study for coronary CT angiographic analysis.

BACKGROUND: Over 50% of women evaluated for suspected ischemia have no obstructive coronary artery disease (INOCA). Statins, angiotensin converting en...

Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease.

OBJECTIVE: This 24-month longitudinal study involving isolated rapid eye movement sleep behavior disorder (iRBD), early-stage Parkinson's disease (PD)...

Quantifying Root Resorption on the Incisors After Clear Aligner and Fixed Appliance Therapy Using Artificial Intelligence Tool Based CBCT Surface Models: Randomized Clinical Trial.

OBJECTIVE: To quantify external apical root resorption (EARR) on the incisors following non-extraction treatment of Class I malocclusion patients with...

Problematizing the role of artificial intelligence in hiring and organizational inequalities: A multidisciplinary review.

What are the implications of the growing use of artificial intelligence (AI) in recruitment and hiring for organizational inequalities? While advocate...

Efficacy and safety of recombinant human bone morphogenetic protein-2 biomaterials in promoting bone regeneration: A systematic review and meta-analysis.

OBJECTIVES: This study aims to systematically evaluate the efficacy and safety of recombinant human bone morphogenetic protein-2 (rhBMP-2) in promotin...

Software-based de-filtering restores quantitative accuracy in Clarity2D-enhanced whole-body bone scintigraphy.

OBJECTIVE: To determine whether software-based de-filtering can restore the quantitative accuracy of the bone scan index (BSI) and the number of hot s...

Vision-language models in diagnostic imaging: review of technical advances, clinical validation, and practical deployment.

BACKGROUND: Radiology faces an unprecedented workload crisis, creating demand for AI solutions to enhance efficiency and quality. Vision-language mode...

A chalcone-rich extract from licorice root inhibits liver steatosis and fibrosis via regulating PPARα and TGFβ signaling.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major liver disorder, which seriously affects human health globally....

Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.

Difficult-to-treat rheumatoid arthritis (D2T RA) is an emerging challenge in aging populations, where disease persistence and therapeutic failure ofte...