Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease.

OBJECTIVE: This 24-month longitudinal study involving isolated rapid eye movement sleep behavior disorder (iRBD), early-stage Parkinson's disease (PD), and matched healthy control subjects aimed to assess whether acoustic speech features from real-world smartphone calls provide passive progressive biomarkers in synucleinopathies. METHODS: Participants underwent clinical assessments at baseline, 1,...

Dec 30 2025 41467327

Quantifying Root Resorption on the Incisors After Clear Aligner and Fixed Appliance Therapy Using Artificial Intelligence Tool Based CBCT Surface Models: Randomized Clinical Trial.

OBJECTIVE: To quantify external apical root resorption (EARR) on the incisors following non-extraction treatment of Class I malocclusion patients with moderate crowding, comparing clear aligners and fixed appliances using a novel 3D analysis of Cone-Beam Computed Tomography (CBCT) derived surface models. METHODS: In this randomized clinical trial, 32 adult patients, mean age 22.3 years, mean treat...

Dec 30 2025 41467333
Problematizing the role of artificial intelligence in hiring and organizational inequalities: A multidisciplinary review.

What are the implications of the growing use of artificial intelligence (AI) in recruitment and hiring for organizational inequalities? While advocate...

Dec 30 2025 41550203
Efficacy and safety of recombinant human bone morphogenetic protein-2 biomaterials in promoting bone regeneration: A systematic review and meta-analysis.

OBJECTIVES: This study aims to systematically evaluate the efficacy and safety of recombinant human bone morphogenetic protein-2 (rhBMP-2) in promotin...

Dec 29 2025 41906828
Software-based de-filtering restores quantitative accuracy in Clarity2D-enhanced whole-body bone scintigraphy.

OBJECTIVE: To determine whether software-based de-filtering can restore the quantitative accuracy of the bone scan index (BSI) and the number of hot s...

Dec 29 2025 41460439
Vision-language models in diagnostic imaging: review of technical advances, clinical validation, and practical deployment.

BACKGROUND: Radiology faces an unprecedented workload crisis, creating demand for AI solutions to enhance efficiency and quality. Vision-language mode...

Dec 28 2025 41483727
A chalcone-rich extract from licorice root inhibits liver steatosis and fibrosis via regulating PPARα and TGFβ signaling.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major liver disorder, which seriously affects human health globally....

Dec 28 2025 41539093
Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.

Difficult-to-treat rheumatoid arthritis (D2T RA) is an emerging challenge in aging populations, where disease persistence and therapeutic failure ofte...

Dec 27 2025 41454175
The Application Effect of Robot-Assisted Therapy for Hand Dysfunction After Stroke: A Scoping Literature Review.

This scoping review was designed to address the core question: In the field of poststroke hand function rehabilitation, what is the current status of ...

Dec 24 2025 41701815
Pediatric asthma management via integration of a remote spirometry device into an EHR-based artificial intelligence-powered clinical decision support system: A feasibility pragmatic clinical trial.

BACKGROUND: Asthma is the most common chronic disease in children. Suboptimal asthma control is prevalent and causes significant health care costs. El...

Dec 24 2025 41453519
The spread of non-native species.

The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions ...

Dec 23 2025 41437262
Understanding the challenges to implementing AI solutions in radiology departments and how to overcome them: A comprehensive review endorsed by the French College of Radiologists (CERF) and the French Society of Radiology (SFR).

Despite the exponential growth of artificial intelligence (AI) solutions designed to assist radiologists in clinical practice, their actual impact on ...

Dec 23 2025 41436332
Estimating the effect of reducing average annual ambient PM2.5 concentrations on allostatic load in children.

OBJECTIVE: Chronic exposure to environmental stressors may result in dysregulation across the body's adaptive stress-response systems, which can be co...

Dec 23 2025 41448418
Bidirectional regulation strategies of food microorganisms based on mechanistic insights into temperature, osmotic, and acid stresses.

Food microorganisms act as a double-edged sword in production and storage. Beneficial microbes create distinctive flavor, texture, and nutritional val...

Dec 20 2025 41539747
Who engages? Machine learning insights into digital mindfulness-based intervention for generalized anxiety disorder.

BACKGROUND: Although mindfulness ecological momentary interventions (MEMI) appear effective in alleviating worry symptoms, treatment engagement remain...

Dec 19 2025 41422949
Research protocol for BootStRaP assessment phase: A nine-nation study on boosting societal adaptation and mental health in a rapidly digitalising, post-pandemic Europe.

BACKGROUND: There is increasing global concern about the harms associated with problematic usage of the internet (PUI) affecting young people. Various...

Dec 19 2025 41496188
Exploring Patients' Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial.

OBJECTIVE: The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyr...

Dec 18 2025 40897521
Development of Digital Literacy: Application of Artificial Intelligence in Education and Clinical Practice of Oncology Nurses.

OBJECTIVES: To synthesize current educational approaches to AI literacy in oncology nursing, identify key competency domains along with barriers and e...

Dec 18 2025 41419399
Intelligent defensive driving for autonomous vehicles: Framework, strategy and verification.

As autonomous driving advances to higher levels, conventional decision-making algorithms for autonomous vehicles (AVs) often inadequately address long...

Dec 16 2025 41406555
Development of a stand-alone eHealth treatment: iCamperdown.

PURPOSE: eHealth treatments have been developed for a range of conditions. They provide an accessible, cost-effective, and convenient model for client...

Dec 16 2025 41418562
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