Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Combatting antimicrobial-resistant Neisseria gonorrhoeae: new antibiotics and the pipeline of antigonococcal therapeutics.

PURPOSE OF REVIEW: Gonorrhea is the second most prevalent bacterial sexually transmitted infection globally. The proliferation of antimicrobial-resistant strains has severely limited treatment options. New treatment modalities against multidrug-resistant gonococcal infections to reduce the rate of transmission and the risk of complications are urgently needed. This review summarizes ongoing effort...

Nov 27 2025 41452091

Clinical Efficacy of Real-Time Artificial Intelligence-Assisted Colonoscopy in Colorectal Polyp Detection: A Prospective Multicenter Randomized Controlled Trial.

BACKGROUND/AIMS: Early detection and removal of colon polyps are critical for preventing colorectal cancer. Computer-aided detection (CADe) systems have been introduced to increase the polyp detection rate (PDR) during colonoscopy, potentially enhancing its effectiveness. This study aimed to evaluate the efficacy of a CADe system in colorectal neoplasm detection. METHODS: This prospective, randomi...

Nov 27 2025 41306099
Artificial Intelligence Technologies Supporting Nurses' Clinical Decision-Making: A Systematic Review.

BACKGROUND: The use of technology to support nurses' decision-making is increasing in response to growing healthcare demands. AI, a global trend, hold...

Nov 25 2025 41292265
Drug Repurposing in Oncology: A Strategic Pathway to Unlocking New Therapeutic Potential.

The growing number of cancer cases and deaths highlights the urgent need for innovative treatment approaches. One technique that has lately been recog...

Nov 19 2025 41258978
Bridging tradition and innovation: Acupuncture for depression through clinical efficacy and neurobiological insights.

BACKGROUND: To elucidate the research progress on acupuncture therapy as a complementary and alternative medicine treatment for depression by reviewin...

Nov 19 2025 41265714
Utility and limitations of the FDA adverse events reporting system public dashboard for safety analyses: a case study with vesicular monoamine transporter 2 inhibitors.

INTRODUCTION: The United States Food and Drug Administration (FDA) requires post-marketing surveillance of approved drugs, and pharmaceutical manufact...

Nov 17 2025 41212745
Efficacy of MRI-based deep learning algorithm for detecting acute ischemic stroke: evaluation among diverse readers.

OBJECTIVES: The efficacy of an MRI-based deep learning algorithm (DLA) for detecting acute ischemic stroke (AIS) was evaluated across readers with div...

Nov 17 2025 41249548
Ethics, economics, and patient-centered outcomes of spinal cord stimulation.

PURPOSE OF THE REVIEW: With the widespread integration of spinal cord stimulation (SCS) into clinical practice, understanding its ethical, economic, a...

Nov 17 2025 41246918
Beyond human gold standards: A multimodel framework for automated abstract classification and information extraction.

Meta-research and evidence synthesis require considerable resources. Large language models (LLMs) have emerged as promising tools to assist in these p...

Nov 17 2025 41635942
The effect of robot-assisted training on burn rehabilitation: A systematic review and meta-analysis.

OBJECTIVE: This study aimed to systematically evaluate the efficacy of robot-assisted training (RAT) in improving the physical rehabilitation outcomes...

Nov 17 2025 41297240
The role of artificial intelligence in co-creation of health professions education: Integrating innovation into collaboration: AMEE Guide No. 190.

Co-creation has emerged as a transformative approach to meaningful collaboration among students, teachers, and other key stakeholders. Although co-cre...

Nov 16 2025 41241925
Targetable atrial tachycardias after artificial intelligence-guided ablation of persistent atrial fibrillation.

BACKGROUND: The TAILORED-AF randomized trial demonstrated that artificial intelligence-guided ablation of spatiotemporal dispersion in addition to pul...

Nov 14 2025 41242590
3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration.

The bone unit (BU) is a multicellular functional unit composed of neuromodulatory networks, bone tissue, and functional blood vessels. As a functional...

Nov 14 2025 41323200
Dynamics and forecasting of an age-structured stochastic SIR model with Lévy perturbations via physics-informed neural networks.

Understanding and predicting real-world epidemic dynamics has consistently posed a formidable challenge. This study addresses an age-structured stocha...

Nov 12 2025 41438605
Robot-assisted gait training for lower limb motor recovery in cerebral palsy: A meta-analysis of combined and standalone approaches.

BACKGROUND: Cerebral palsy (CP), a leading cause of childhood motor disability, severely impacts lower limb function. Conventional gait training (CGT)...

Nov 12 2025 41252866
Real-time photoelectric sensing of edaravone for therapeutic efficacy in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) requires precise therapeutic monitoring of Edaravone, but current methods lack real-time capability. Herein, we de...

Nov 10 2025 41240557
Automatic segmentation and CT-based deep learning radiomics nomogram for predicting overall survival in patients with small cell lung cancer: A multicenter cohort study.

BACKGROUND AND OBJECTIVE: Accurate prediction of overall survival (OS) in patients with small cell lung cancer (SCLC) is crucial for personalized trea...

Nov 10 2025 41252869
Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.

BACKGROUND: Major adverse cardiovascular events (MACE)-cardiovascular (CV) death, nonfatal myocardial infarction (MI), and nonfatal stroke-are highly ...

Nov 9 2025 41493293
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