Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Safe Physics-Informed Machine Learning for Optimal Predefined-Time Stabilization: A Lyapunov-Based Approach.

In this article, we introduce the notion of safe predefined-time stability and address an optimal safe predefined-time stabilization problem. In particular, safe predefined-time stability characterizes parameter-dependent nonlinear dynamical systems whose trajectories starting in a given set of admissible states remain in the set of admissible states for all time and converge to an equilibrium poi...

May 26 2025 40418613

RGE-YOLO enables lightweight road packaging bag detection for enhanced driving safety.

Foreign objects such as packaging bags on the road pose a significant threat to driving safety, especially at high speeds or under low-visibility conditions. However, research on detecting road packaging bags remains limited, and existing object detection models face challenges in small object detection, computational efficiency, and embedded deployment. To address these issues, the lightweight de...

May 26 2025 40419594
Biparametric Prostate MRI: A Practical Approach to Implementation and Comparative Analysis.

Prostate cancer (PCa) remains a leading cause of cancer-related morbidity and mortality among men worldwide. Multiparametric MRI (mpMRI) is currently ...

May 26 2025 40420568
Adaptive Machine Learning Framework enables Unprecedented Yield and Purity of Adeno-Associated Viral Vectors for Gene Therapy.

Adeno-associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed...

May 24 2025 40475650
Role of artificial intelligence in cancer drug discovery and development.

The role of artificial intelligence (AI) in cancer drug discovery and development has garnered significant attention due to its potential to transform...

May 23 2025 40414522
Shining the Beam on the Next Generation: A Program Evaluation of a National Workshop Focusing on Medical Student Engagement in Radiation Oncology.

The rising cancer incidence has increased demand for radiation oncologists, surpassing current staffing expansion estimates. Enhancing radiation oncol...

May 23 2025 40408068
Effectiveness of hypotension prediction index software in reducing intraoperative hypotension in prolonged prone-position spine surgery: a single-center clinical trial.

Intraoperative hypotension (IOH) is associated with morbidity and mortality. The Hypotension Prediction Index (HPI), a machine learning-based tool, of...

May 23 2025 40410627
Development and Effectiveness of a Clinical Decision Support System for Postembolization Syndrome after Transarterial Chemoembolization: A Randomized Controlled Trial.

PURPOSE: Based on the frequency of postembolization syndrome (PES) after transarterial chemoembolization (TACE), early detection and management of sym...

May 23 2025 40414343
Towards precision medicine in antiphospholipid syndrome.

Antiphospholipid syndrome is a rare systemic autoimmune disorder with complex pathophysiology and high heterogeneity in clinical presentation and trea...

May 23 2025 40418947
Optimizing Treatment for Depression in Primary Care Using Psychotherapy Versus Antidepressant Medication in a Low-Resource Setting: Protocol for the OptimizeD Randomized Controlled Trial.

Psychotherapy and antidepressant medications are first-line treatments for depression, and they both have significant treatment effects on average. H...

May 23 2025 40470239
Ambient technology in epilepsy clinical practice.

The utilization of large language model-based artificial intelligence (AI) in the field of neurology has gained attention as a viable tool to enhance ...

May 22 2025 40402540
Effectiveness and Methodologies of Virtual Reality Dental Simulators for Veneer Tooth Preparation Training: Randomized Controlled Trial.

BACKGROUND: Virtual reality (VR) simulators are increasingly used in dental education, offering advantages such as repeatable practice and immediate f...

May 22 2025 40402564
From Pixels to Patterns: Trait Plasticity and Species Overlap of spp. in Arctic Fjords.

The marine ecosystems of the Svalbard archipelago are now propelled towards a new climatic state owing to the ongoing "Atlantification" process. Fjord...

May 22 2025 40416767
Influence of the CONCERN Early Warning System on Unanticipated ICU Transfers, In-Hospital Mortality, and Length of Stay: Results from a Multi-site Pragmatic Randomized Controlled Clinical Trial.

Communicating Narrative Concerns Entered by RNs Early Warning System (CONCERN EWS) is a machine-learning predictive model that leverages nursing surve...

May 22 2025 40417527
The Effectiveness of a Chatbot Single-Session Intervention for People on Waitlists for Eating Disorder Treatment: Randomized Controlled Trial.

BACKGROUND: Early treatment is critical for improving eating disorder prognosis. Single-session interventions (SSIs) can provide short-term support to...

May 21 2025 40397933
Network models incorporating chloride dynamics predict optimal strategies for terminating status epilepticus.

Status epilepticus (SE), seizures lasting beyond five minutes, is a medical emergency commonly treated with benzodiazepines which enhance GABA recepto...

May 20 2025 40404062
In pursuit of software solutions for pharmaceutical regulatory affairs: Insights and trends.

With rapid upsurge in technology and digital tools, the existing systems including the healthcare systems, especially the pharmaceutical sector is exp...

May 20 2025 40403839
Strategies to Reduce Hospital Length of Stay: Evidence and Challenges.

Hospital length of stay (HLOS) is a critical healthcare metric influencing patient outcomes, resource utilization, and healthcare costs. While reducin...

May 20 2025 40428880
Machine-learning-assisted universal protein activation in living mice.

A universal strategy to precisely control protein activation in living animals is crucial for gain-of-function study of proteins under in vivo setting...

May 20 2025 40436016
Uncemented hip arthroplasty and denosumab: increased postoperative dipeptide concentrations and identification of potential new bone turnover biomarkers.

Denosumab is a potent antagonist of RANKL and is widely used to treat severe postmenopausal osteoporosis. Using high-resolution mass spectrometry (HRM...

May 19 2025 40584156
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