Clinical Trials

Advanced traffic conflict analysis for safety evaluation at roundabouts under mixed traffic using extreme value theory.

Roundabout safety evaluation in non-lane-based, heterogeneous traffic conditions in low-middle-income countries brings challenges due to unavailable/unreliable crash data, thereby switching to the utilization of safety surrogates. This study employed high-resolution drone videos and advanced image-processing techniques to extract vehicular trajectories. Traffic conflicts were identified using Surr...

Use of Virtual Reality in the Pediatric Perioperative Setting and for Induction of Anesthesia: Mixed Methods Pilot Feasibility Study.

BACKGROUND: Children commonly experience high levels of anxiety prior to surgery. This distress is associated with postoperative maladaptive behaviors. Virtual reality (VR) is an innovative tool for reducing anxiety and pain during various medical procedures. Previous randomized controlled trials have demonstrated its efficacy in reducing children's anxiety in the preoperative waiting room or duri...

Artificial Intelligence (AI)-Driven Approaches to Manage Postoperative Pain, Anxiety, and Psychological Outcomes in Surgical Patients: A Systematic Review.

Postoperative pain, anxiety, and psychological distress significantly impact surgical recovery, yet conventional management strategies often lack pers...

Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners.

Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction...

Estimation of patient safety culture in private and public hospitals using machine learning methods.

BackgroundPatient safety is a critical component of health care systems. Large groups of patients, as a result of medical errors, are at risk of harm....

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thr...

From error to prevention of wrong-level spine surgery: a review.

Wrong-level spine surgery remains a significant concern in spine surgery, leading to devastating consequences for patients and healthcare systems alik...

Deciphering the Immunomodulatory Function of GSN Inflammatory Cancer-Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan-Cancer Single-Cell Landscape and Spatial Transcriptomics Analysis.

The heterogeneity of cancer-associated fibroblasts (CAFs) could affect the response to immune checkpoint inhibitor (ICI) therapy. However, limited stu...

Dexmedetomidine versus Magnesium Sulphate in Ultrasound-Guided Bilateral bi-Level Erector Spinae Plane Block in Corrective Scoliosis Surgery: A Randomized Controlled Clinical Trial.

OBJECTIVES: There is a scarcity of research regarding the effects of LAs adjuvant drugs in erector spinae plane block (ESPB), especially in scoliosis ...

Push Forward Clinical Management of Hematological Toxicity due to Lenalidomide Overexposure: Model-Informed Precision Dosing for Chinese Population With Renal Insufficiency.

Dose-dependent hematological toxicity of lenalidomide has been reported previously, and thus, there is a clinical need for dose individualization to m...

Maternal and umbilical cord plasma purine concentrations after oral carbohydrate loading prior to elective Cesarean delivery under spinal anesthesia: a randomized controlled trial.

OBJECTIVE: To evaluate the effect of preoperative intake of oral carbohydrates versus standard preoperative fasting prior to elective cesarean deliver...

Dual-action membrane-chimeric liposomes with self-reinforcing targeting for acute lung injury treatment.

Acute lung injury (ALI) is a common acute and critical syndrome with high mortality. The uncontrollable feedback loop of inflammation is the primary c...

Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.

BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advance...

The impact of a simple positioning aid device on the diagnostic performance of thyroid cancer in CT scans: a randomized controlled trial.

OBJECTIVE: To evaluate the effectiveness of a simple positioning aid device in neck CT scans for the diagnosis of thyroid cancer, with a focus on its ...

Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial.

BACKGROUND: Extubation failure leading to reintubation is associated with high mortality. In patients at high-risk of extubation failure, clinical pra...

Promethazine for nausea and vomiting prevention after gynaecological laparoscopic surgery: A randomized controlled trial.

Postoperative nausea and vomiting (PONV) represent significant concerns for patients undergoing surgical procedures, as these symptoms greatly impact ...

A Randomized, Blinded, Placebo-Controlled Crossover Study of the Pharmacokinetics and Pharmacodynamics of Naloxone, Naltrexone, and Nalmefene in Methadone-Sedated Working Dogs.

A randomized, blinded, placebo-controlled crossover study was performed with eight professional working dogs to evaluate the pharmacokinetics and phar...

Simultaneous initiation of dolutegravir-based antiretroviral therapy and once-weekly rifapentine and isoniazid for tuberculosis prevention in antiretroviral-naive people with HIV: an open-label, non-randomised, phase 1/2 trial.

BACKGROUND: Tuberculosis preventive treatment with 3 months of once-weekly isoniazid (900 mg) and rifapentine (900 mg; 3HP) is a recommended option fo...

Smartphone-integrated Nanozyme approaches for rapid and on-site detection: Empowering smart food safety.

Smartphone-integrated nanozyme technologies (S-INTs) have emerged as a promising solution for rapid, on-site food safety analysis, addressing the dete...

Mechanisms and Applications of Apolipoproteins and Apolipoprotein Mimetic Peptides: Common Pathways in Cardiovascular Disease and Cancer.

Apolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprot...