Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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The transformative potential of AI-driven CRISPR-Cas9 genome editing to enhance CAR T-cell therapy.

This narrative review examines the promising potential of integrating artificial intelligence (AI) with CRISPR-Cas9 genome editing to advance CAR T-cell therapy. AI algorithms offer unparalleled precision in identifying genetic targets, essential for enhancing the therapeutic efficacy of CAR T-cell treatments. This precision is critical for eliminating negative regulatory elements that undermine t...

Sep 10 2024 39260044

Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?

Despite implementing hundreds of strategies, cancer drug development suffers from a 95% failure rate over 30 years, with only 30% of approved cancer drugs extending patient survival beyond 2.5 months. Adding more criteria without eliminating nonessential ones is impractical and may fall into the "survivorship bias" trap. Machine learning (ML) models may enhance efficiency by saving time and cost. ...

Sep 10 2024 39253942
Intelligent Control System for Brain-Controlled Mobile Robot Using Self-Learning Neuro-Fuzzy Approach.

Brain-computer interface (BCI) provides direct communication and control between the human brain and physical devices. It is achieved by converting EE...

Sep 10 2024 39338620
Artificial Intelligence in the Training of Radiology Residents: a Multicenter Randomized Controlled Trial.

The aim of the present study was to compare the effectiveness of AI-assisted training and conventional human training in clinical practice. This was a...

Sep 7 2024 39242467
State transition learning with limited data for safe control of switched nonlinear systems.

Switching dynamics are prevalent in real-world systems, arising from either intrinsic changes or responses to external influences, which can be approp...

Sep 3 2024 39270350
Ethical Considerations in the Design and Conduct of Clinical Trials of Artificial Intelligence.

IMPORTANCE: Safe integration of artificial intelligence (AI) into clinical settings often requires randomized clinical trials (RCT) to compare AI effi...

Sep 3 2024 39240560
Managing workplace AI risks and the future of work.

Artificial intelligence (AI)-the field of computer science that designs machines to perform tasks that typically require human intelligence-has seen r...

Sep 2 2024 39223704
Artificial intelligence guided screening for cardiomyopathies in an obstetric population: a pragmatic randomized clinical trial.

Nigeria has the highest reported incidence of peripartum cardiomyopathy worldwide. This open-label, pragmatic clinical trial randomized pregnant and p...

Sep 2 2024 39223284
Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation.

Conflicting clinical trial results on omega-3 highly unsaturated fatty acids (n-3 HUFA) have prompted uncertainty about their cardioprotective effects...

Sep 2 2024 39275249
A Novel Evaluation Framework for Medical LLMs: Combining Fuzzy Logic and MCDM for Medical Relation and Clinical Concept Extraction.

Artificial intelligence (AI) has become a crucial element of modern technology, especially in the healthcare sector, which is apparent given the conti...

Aug 31 2024 39214943
Novel glassbox based explainable boosting machine for fault detection in electrical power transmission system.

The reliable operation of electrical power transmission systems is crucial for ensuring consumer's stable and uninterrupted electricity supply. Faults...

Aug 28 2024 39196913
Digital health in stroke: a narrative review.

Digital health is significantly transforming stroke care, particularly in remote and economically diverse regions, by harnessing mobile and wireless t...

Aug 26 2024 39187259
Effect of a Group-Based Personal Assistive RObot (PARO) Robot Intervention on Cognitive Function, Autonomic Nervous System Function, and Mental Well-being in Older Adults with Mild Dementia: A Randomized Controlled Trial.

OBJECTIVES: Personal Assistive RObot (PARO) interventions have been used to treat agitation and mood symptoms of dementia effectively. However, the ef...

Aug 22 2024 39182512
Recruitment in Appalachian, Rural and Older Adult Populations in an Artificial Intelligence World: Study Using Human-Mediated Follow-Up.

BACKGROUND: Participant recruitment in rural and hard-to-reach (HTR) populations can present unique challenges. These challenges are further exacerbat...

Aug 22 2024 39173153
LERCause: Deep learning approaches for causal sentence identification from nuclear safety reports.

Identifying causal sentences from nuclear incident reports is essential for advancing nuclear safety research and applications. Nonetheless, accuratel...

Aug 22 2024 39172869
Gauging road safety advances using a hybrid EWM-PROMETHEE II-DBSCAN model with machine learning.

INTRODUCTION: Enhancing road safety conditions alleviates socioeconomic hazards from traffic accidents and promotes public health. Monitoring progress...

Aug 22 2024 39238537
Feasibility of Artificial Intelligence Powered Adverse Event Analysis: Using a Large Language Model to Analyze Microwave Ablation Malfunction Data.

Determine if a large language model (LLM, GPT-4) can label and consolidate and analyze interventional radiology (IR) microwave ablation device safety...

Aug 21 2024 39169480
Novel Machine Learning HIV Intervention for Sexual and Gender Minority Young People Who Have Sex With Men (uTECH): Protocol for a Randomized Comparison Trial.

BACKGROUND: Sexual and gender minority (SGM) young people are disproportionately affected by HIV in the United States, and substance use is a major dr...

Aug 20 2024 39163591
Integrating ChatGPT in Orthopedic Education for Medical Undergraduates: Randomized Controlled Trial.

BACKGROUND: ChatGPT is a natural language processing model developed by OpenAI, which can be iteratively updated and optimized to accommodate the chan...

Aug 20 2024 39163598
Machine learning and natural language processing in clinical trial eligibility criteria parsing: a scoping review.

Automatic eligibility criteria parsing in clinical trials is crucial for cohort recruitment leading to data validity and trial completion. Recent year...

Aug 19 2024 39154773
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