Oncology/Hematology

Colon Cancer

Latest AI and machine learning research in colon cancer for healthcare professionals.

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Conversational Artificial Intelligence Agents-Enabled Dissection of RTK-RAS and MAPK Pathway Dependencies in Gemcitabine-Treated Pancreatic Ductal Adenocarcinoma (PDAC)

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by profound molecular heterogeneity and inconsistent responses to gemcitabine-based therapy. Although KRAS mutations are nearly ubiquitous, the broader RTK-RAS and MAPK signaling networks, and their association with therapeutic response, remain insufficiently characterized. We performed an integrative clinical-genomi...

Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic Therapies

Differences in microbiome composition profoundly influence drug response, yet methods to model the metabolic interplay between tumors, microbes, and therapeutics remain limited. We present a generalizable framework combining machine learning and genome scale metabolic modeling to prioritize combination therapies for colorectal cancer (CRC) in the presence of Fusobacterium nucleatum (Fn) and other ...

CMSA-Net: Causal Multi-scale Aggregation with Adaptive Multi-source Reference for Video Polyp Segmentation

Video polyp segmentation (VPS) is an important task in computer-aided colonoscopy, as it helps doctors accurately locate and track polyps during exami...

Feb 26 2026 2602.22821v1
ColoDiff: Integrating Dynamic Consistency With Content Awareness for Colonoscopy Video Generation

Colonoscopy video generation delivers dynamic, information-rich data critical for diagnosing intestinal diseases, particularly in data-scarce scenario...

Feb 26 2026 2602.23203v1
Structure-to-Image: Zero-Shot Depth Estimation in Colonoscopy via High-Fidelity Sim-to-Real Adaptation

Monocular depth estimation (MDE) for colonoscopy is hampered by the domain gap between simulated and real-world images. Existing image-to-image transl...

Feb 25 2026 2602.21740v1
Inference of cancer driver mutations from tumor microenvironmentcomposition: a pan-cancer study with cross-platform external validation

Cancer driver mutations shape the tumor microenvironment (TME), yet whether TME composition alone can predict genotype has not been systematically eva...

Accelerated sampling of protein dynamics using BioEmu augmented molecular simulation

We introduce a workflow that integrates BioEmu-generated conformational ensemble with physics-based molecular simulations and Markov State Models to s...

From Global Radiomics to Parametric Maps: A Unified Workflow Fusing Radiomics and Deep Learning for PDAC Detection

Radiomics and deep learning both offer powerful tools for quantitative medical imaging, but most existing fusion approaches only leverage global radio...

Feb 20 2026 2602.17986v1
Multi-Modal Monocular Endoscopic Depth and Pose Estimation with Edge-Guided Self-Supervision

Monocular depth and pose estimation play an important role in the development of colonoscopy-assisted navigation, as they enable improved screening by...

Feb 19 2026 2602.17785v1
Attachment Anchors: A Novel Framework for Laparoscopic Grasping Point Prediction in Colorectal Surgery

Accurate grasping point prediction is a key challenge for autonomous tissue manipulation in minimally invasive surgery, particularly in complex and va...

Feb 19 2026 2602.17310v1
Biomarker Identification in Pancreatic Cancer Through Concordant Differential Expression and Interpretable Machine Learning Analyses

Background: Pancreatic ductal adenocarcinoma is one of the most aggressive and lethal malignancies of the gastrointestinal tract. The poor prognosis i...

Network-based integration of gene expression and DNA methylation identifies prognostic biomarkers for early-stage pancreatic cancer

Pancreatic ductal adenocarcinoma remains one of the most lethal malignancies, largely due to the absence of reliable early stage biomarkers. Here, we ...

Decoding Future Risk: Deep Learning Analysis of Tubular Adenoma Whole-Slide Images

Colorectal cancer (CRC) remains a significant cause of cancer-related mortality, despite the widespread implementation of prophylactic initiatives aim...

Feb 9 2026 2602.09155v1
RealSynCol: a high-fidelity synthetic colon dataset for 3D reconstruction applications

Deep learning has the potential to improve colonoscopy by enabling 3D reconstruction of the colon, providing a comprehensive view of mucosal surfaces ...

Feb 9 2026 2602.08397v1
Identification of Novel mRNA Biomarkers with Improved Performance for Colorectal Cancer Screening from a Multicenter Large Gene Screen

Abstract Background: Colorectal cancer (CRC) is a leading cause of cancer mortality. While early detection improves outcomes, current non-invasive tes...

SCOPE: AI-Assisted Early Detection of Potentially Curable Pancreatic Neoplasms on CT from Local and Global Information

Purpose: To develop SCOPE (Small-lesion COntextual Pancreatic Evaluator), a deep learning model designed to improve CT detection of small pancreatic l...

Vision Transformers Based AI Models For Predicting Colorectal Cancer from Digital Pathology WSI: Use Case Of MHIST dataset

This study investigates the efficacy of transformer-based deep learning architectures-specifically, Vision Transformer (ViT), Class Attention in Image...

Fast Organ-of-Origin Classification for Digital Pathology Quality Control

Digitizing large histopathology archives requires processing millions of scanned whole slide images that must be validated rapidly. Automated organ-of...

Enabling Real-Time Colonoscopic Polyp Segmentation on Commodity CPUs via Ultra-Lightweight Architecture

Early detection of colorectal cancer hinges on real-time, accurate polyp identification and resection. Yet current high-precision segmentation models ...

Feb 4 2026 2602.04381v1
XtraLight-MedMamba for Classification of Neoplastic Tubular Adenomas

Accurate risk stratification of precancerous polyps during routine colonoscopy screenings is essential for lowering the risk of developing colorectal ...

Feb 4 2026 2602.04819v1
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