Colon Cancer

Machine learning based obesity and aging related signature for predicting the prognosis and immunotherapy benefit in stomach adenocarcinoma.

BACKGROUND: Stomach adenocarcinoma (STAD) is one of most common cancers with high invasiveness and poor prognosis. Obesity and aging are correlated with higher risk for cancer development and worse prognosis in certain types of malignancies.

Screening and validation of long non-coding RNAs associated with colorectal cancer based on random forest and LASSO regression algorithm.

OBJECTIVE: Colorectal cancer (CRC) ranks as the third most prevalent contributor to global disease burden and represents the second highest mortality rate among all malignancies worldwide. Long non-coding RNAs (lncRNAs) are a new class of regulatory RNAs, which play a crucial role in the occurrence and development of colorectal cancer. Therefore, it is potentially important to use bioinformatics a...

Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing.

Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). We examined CAF subgroups via gene ontolog...

A novel approach to overcome black box of AI for optical diagnosis in colonoscopy.

Accurate real-time optical diagnosis that distinguishes neoplastic from non-neoplastic colorectal lesions during colonoscopy can lower the costs of pa...

Integrated analysis of shared gene expression signatures and immune microenvironment heterogeneity in type 2 diabetes mellitus and colorectal cancer.

Emerging evidence suggests a bidirectional relationship between colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM), yet the shared molecular ...

Activated cancer-associated fibroblasts correlate with poor survival and decreased lymphocyte infiltration in infiltrative type distal cholangiocarcinoma.

Cancer-associated fibroblasts promote tumor progression through growth facilitation, invasion, and immune evasion. This study investigated the impact ...

Development and validation of CT-based fusion model for preoperative prediction of invasion and lymph node metastasis in adenocarcinoma of esophagogastric junction.

PURPOSE: In the context of precision medicine, radiomics has become a key technology in solving medical problems. For adenocarcinoma of esophagogastri...

Can mutation abundance assess the biological behavior of BRAF-positive papillary thyroid carcinoma?

BACKGROUND: BRAF mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF mutation ...

2.5D deep learning radiomics and clinical data for predicting occult lymph node metastasis in lung adenocarcinoma.

BACKGROUND: Occult lymph node metastasis (OLNM) refers to lymph node involvement that remains undetectable by conventional imaging techniques, posing ...

Risk factors and prediction of distant metastasis (DM) of colon adenocarcinoma: a logistic regression and machine learning study based on surveillance, epidemiology, and end results (SEER) database.

An interpretable machine learning model for predicting early liver metastasis after pancreatic cancer surgery.

BACKGROUND: Liver metastasis is the most frequent site of distant metastasis in pancreatic ductal adenocarcinoma (PDAC), significantly contributing to...

Impact of Introducing Artificial Intelligence on Colonoscopy: A Retrospective Study on Potential Benefits and Drawbacks.

BACKGROUND AND AIM: Computer-aided detection (CAD) can improve adenoma detection rates (ADRs); however, the impact of its introduction into real-world...

Taking the Guess Work Out of Endoscopic Polyp Measurement: From Traditional Methods to AI.

Colonoscopy is a crucial tool for evaluating lower gastrointestinal disease, monitoring high-risk patients for colorectal neoplasia, and screening for...

Establishment of a machine learning-based predictive model with dual-center external validation: investigating the role of robotic surgery in preventing delayed gastric emptying for right-sided colon cancer.

After colorectal surgery, delayed gastric emptying (DGE) is a clinically significant postoperative complication that significantly lowers patients' qu...

Unraveling the role of perineural invasion in cancer progression across multiple tumor types.

Perineural invasion (PNI) refers to the infiltration of tumor cells into the connective tissue of nerves and is increasingly recognized as a pathologi...

CRCpred: An AI-ML tool for colorectal cancer prediction using gut microbiome.

Colorectal cancer (CRC) is a leading cause of death worldwide. A plethora of research shows the alteration of the gut microbiome and the association o...

Fecal volatile organic compounds for colorectal cancer detection: A systematic review and meta-analysis.

BACKGROUND: Background: Fecal volatile organic compound (VOC) analysis has emerged as a promising non-invasive tool for detecting colorectal cancer (C...

Exploring the complex interplay between oral infection, periodontitis, and robust microRNA induction, including multiple known oncogenic miRNAs.

() is an oral commensal bacterium that can become pathogenic and is associated with periodontitis, adverse pregnancy outcomes, and colorectal cancer ...

Artificial Intelligence-Powered Spatial Analysis of Immune Phenotypes in Resected Pancreatic Cancer.

IMPORTANCE: Although tumor-infiltrating lymphocytes (TILs) have been implicated as prognostic biomarkers across various malignancies, the clinical app...

Using a Multilingual AI Care Agent to Reduce Disparities in Colorectal Cancer Screening for Higher Fecal Immunochemical Test Adoption Among Spanish-Speaking Patients: Retrospective Analysis.

BACKGROUND: Colorectal cancer (CRC) screening rates remain disproportionately low among Hispanic and Latino populations compared to non-Hispanic White...