Latest AI and machine learning research in cultural competence for healthcare professionals.
Functional RNAs perform diverse catalytic roles, yet natural sequences represent only a narrow subset of what is possible. Rediscovering such activities requires exploring functional sequence diversity beyond natural RNAs. We introduce a hybrid generative model that combines a coevolutionary likelihood with an RNA secondary structure prior. This approach disentangles folding constraints from funct...
Diversity exists throughout biology, playing an important role in maintaining robustness and stability. The same is true of the brain, as has become increasingly apparent in recent years with the accumulation of datasets of unparalleled resolution. These datasets show widespread neural heterogeneity, spanning cells, circuits and system dynamics, marking it as an unavoidable component of the brain’...
Bacteria use antagonistic interbacterial weapons such as polymorphic toxin secretion systems (TSS) to compete for niches in the human gut microbiome. ...
Pathogenic KCNQ2 variants are associated with developmental and epileptic encephalopathy (KCNQ2-DEE), a devastating disorder characterized by neonatal...
Humans seamlessly process multi-voice music into a coherent perceptual whole. Yet the neural strategies supporting this experience remain unclear. One...
Recognition of protospacer adjacent motifs (PAMs) is crucial for target site recognition by CRISPR–Cas systems. In genome editing applications, the re...
Memories are spontaneously replayed during sleep, a process thought to support memory consolidation. However, capturing this replay in humans has been...
The development of highly accurate protein structure prediction algorithms has led to an explosion of structural data, transforming our understanding ...
Cyclic peptides are becoming attractive molecules for drug discovery because of their properties with inherent stability and structural diversity. How...
Dietary proteins are major modulators of gut microbial ecology, yet the microbial signatures and functional consequences of plant-versus animal-based ...
The application of artificial intelligence (AI)/machine learning (ML) to MRI can be a powerful tool to streamline clinical decision-making, yet variab...
Light-sensitive proteins allow organisms to perceive and respond to their environment, and have diversified over billions of years. Among these, Light...
Malassezia pachydermatis is a zoophilic yeast found on the skin and in the outer ear canal of many mammals. It normally maintains a commensal lifestyl...
Type 1 diabetes (T1D) is associated with microbial dysbiosis. While most research has focused on the gut microbiome, limited data address the role of ...
Traditional infectivity-based virion quantification methods, such as 50% tissue culture infectious dose (TCID50) and plaque assays, are typically perf...
Peptide-based drug design targeting “undruggable” proteins remains one of the most critical challenges in modern drug discovery. Conventional peptide-...
Precise profiling of epigenomes is essential for better understanding chromatin biology and gene regulation. Cleavage Under Targets & Tagmentation (CU...
Overfishing has severely depleted marine populations worldwide, including within protected areas. Illegal and unreported fishing are major contributor...
Does favoring less valuable options that deliver more frequent rewards reflect flawed decision-making or an adaptive strategy under complex environmen...
Identifying behavioral and physiological responses to rewarding stimuli is essential for understanding positive emotional states in animals and for in...