Diabetes

DRPM: An advanced predictive model for early diabetes detection and risk stratification.

Diabetes is a prevalent chronic disease that poses a significant burden on individuals and healthcar...

Tilorone attenuates high-fat diet-induced hepatic steatosis by enhancing BMP9-Smad1/5/8 signaling.

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increa...

A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets.

Accurate detection of insulin secretion from pancreatic beta cells is crucial for understanding norm...

Regression and machine learning approaches identify potential risk factors for glioblastoma multiforme.

Glioblastoma multiforme is a lethal disease, with a 5-year survival rate of <10%. The identification...

Type 2 Diabetes in Taiwan: Unmasking Influential Factors Through Advanced Predictive Modeling.

Type 2 diabetes (T2D) is influenced by lifestyle, genetics, and environmental conditions. By utiliz...

Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy.

The pathogenesis of diabetic cardiomyopathy (DCM) remains incompletely understood. The present study...

EEG microstate analysis in trigeminal neuralgia: identifying potential biomarkers for enhanced diagnostic accuracy.

OBJECTIVE: This study investigated EEG microstate dynamics in trigeminal neuralgia (TN) patients to ...

Continuous glucose monitoring combined with artificial intelligence: redefining the pathway for prediabetes management.

Prediabetes represents an early stage of glucose metabolism disorder with significant public health ...

Early detection of retinal and choroidal microvascular impairments in diabetic patients with myopia.

PURPOSE: To evaluate and quantify diabetes-related retinal and choroid perfusion changes in individu...

Mechanisms underlying obesity-malignancy connection: a systematic narrative review.

The association between obesity and cancer risk carries substantial public health ramifications as o...

[Automated diabetic retinopathy screening in out-patient diabetes care - comparison of two artificial intelligence algorithms RetCAD and OphtAI].

Impact of hyperglycaemia on cellular microenvironment and function of endometrium and uterine tube: scoping review focused on infertility in diabetic women.

INTRODUCTION: Diabetes mellitus (DM) and associated comorbidities correspond to female infertility b...

Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis.

OBJECTIVE: This study aims to investigate the molecular mechanisms by which quercetin facilitates th...

Cost-effectiveness of the 3E model in diabetes management: a machine learning approach to assess long-term economic impact.

BACKGROUND: This study investigated the cost-effectiveness and clinical impact of the 3E model (educ...

Artificial Intelligence-Based Detection of Diabetic Retinopathy.

Artificial Intelligence-Based Detection of Diabetic Retinopathy-Reply.

Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors.

α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target...

Discovery of novel potential 11β-HSD1 inhibitors through combining deep learning, molecular modeling, and bio-evaluation.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been shown to play an important role in the t...

The Role of HbA1c in Parkinson's Disease: An Integrative Analysis by Single-Cell, Bulk Transcriptome and Mendelian Randomization.

Decreased glucose tolerance is recognized as a factor associated with Parkinson's disease (PD) progr...

Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients.

BACKGROUND: Diabetic osteoporosis (DOP) can cause abnormal brain neural activity, but its mechanism ...

Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity.

Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show th...