Diabetes

Diagnostic model and identification of IGFBP2 as an aging-related biomarker and therapeutic target for systemic sclerosis-associated interstitial lung disease through integrated bioinformatics and machine learning approaches.

BACKGROUND: Cellular senescence is a critical contributor to the pathogenesis of systemic sclerosis-associated interstitial lung disease (SSc-ILD). However, the roles of aging-related genes in disease onset and progression remain unclear. We aimed to identify the clinical features and senescence-associated genetic signatures of SSc-ILD and validate the role of insulin-like growth factor-binding pr...

De novo generation and in silico screening of anti-diabetic peptide candidates via a deep learning-attention framework with physicochemical feature fusion.

Leveraging natural language processing and machine learning to identify chronic conditions from primary care electronic medical records.

Primary care electronic medical records (EMRs) contain rich data that can support proactive identification of chronic health conditions. However, leve...

From Observation to Prediction: Machine Learning Analysis of Progression of Visual loss in Nonarteritic Anterior Ischemic Optic Neuropathy.

OBJECTIVE: To determine whether combinations of modifiable clinical/systemic risk factors and structured trial variables predict early disease progres...

AFTS: A patient-agnostic encoder-decoder architecture with directional attention for blood glucose forecasting.

Accurate blood glucose forecasting remains challenging due to inter-patient heterogeneity and complex glycemic dynamics. We present AFTS (Adaptive Fea...

External validation of GDM risk prediction models using a machine learning reciprocal model-exchange framework.

BACKGROUND: Although many risk prediction models have been developed, very few undergo external validation, primarily due to issues with data access. ...

Phenotypic clustering of cardiovascular risk profiles in systemic lupus erythematosus.

ObjectiveThis study aimed to identify distinct cardiovascular risk phenotypes in systemic lupus erythematosus (SLE) using an unsupervised cluster anal...

Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker.

BACKGROUND: Endometrial cancer (EC) is a common gynecological tumor. Insulin resistance (IR) increases the risk of EC. However, the common molecular b...

A Comprehensive Approach to Days' Supply Estimation in a Real-World Prescription Database: Algorithm Development and Validation Study.

BACKGROUND: For accurate medication usage statistics and medication adherence calculations, we need to have an accurate days' supply (DS) for each pre...

Artifact-suppressed 3D retinal microvascular segmentation via multi-scale topology regulation.

Optical coherence tomography angiography (OCTA) enables non-invasive visualization of retinal microvasculature, and accurate 3D vessel segmentation is...

Limitation of existing GFR estimating equations and application of artificial intelligence in improving GFR estimation and chronic kidney disease progression in people with diabetes.

The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 equation is the most commonly used equation for estimating glomerular filtration ...

Comparison of ChatGPT-4 and ChatGPT-4 Plus Responses to Retinopathy of Prematurity-Related Questions and Performance Evaluation in Different Languages.

PURPOSE: To compare the accuracy and performance of the ChatGPT-4 and ChatGPT-4 Plus (OpenAI) models in different languages in terms of questions abou...

Data-driven subgroups for 3-year risk stratification of incident diabetes and complications in diabetes-free Chinese adults.

BACKGROUND: Substantial metabolic heterogeneity exists prior to the development of diabetes, creating opportunities for earlier and more precise inter...

A Cross-Sectional Study Based on Deep Learning to Explore the Effect of Triglyceride/Glucose Index on Periodontitis: An Analysis Based on the Large NHANES Database.

PURPOSE: Periodontitis is a common chronic inflammatory disease closely associated with metabolic syndrome. The triglyceride-glucose (TyG) index is a ...

Comprehensive 3D Optical Coherence Tomography Dataset for AMD and DME: Facilitating Deep-Learning-Based 3D Segmentation.

Age-related macular degeneration (AMD) and diabetic macular edema (DME) are vision-threatening pathologies for which optical coherence tomography (OCT...

Enhanced diabetes prediction using pre-trained CNNs, LSTM, and conditional GAN on transformed numerical data.

Diabetes remains a major public health challenge, contributing to complications such as kidney disease, cardiovascular disorders, and diabetic retinop...

Health-oriented sleep states: making sleep states reflect health conditions.

STUDY OBJECTIVES: The rich information in sleep offers insights into brain function and overall health. The current guidelines for sleep staging by th...

Quantitative Assessment of the Extent of Retinal Vascularization in Retinopathy of Prematurity.

OBJECTIVE: To evaluate pixel-based measurements of the minimum nasal and temporal extent of retinal vascularization (NERV and TERV) from RetCam images...

Personalized Diabetes Treatment Support Using Large Language Models Fine-Tuned on Electronic Health Records: Development and Evaluation Study.

BACKGROUND: Effective diabetes management requires individualized treatment strategies tailored to patients' clinical characteristics. With recent adv...

Explainable AI-based analysis of human pancreas sections identifies traits of type 2 diabetes.

Type 2 diabetes (T2D) is a chronic disease currently affecting around 500 million people worldwide with often severe health consequences. Yet, histopa...