Domestic Violence

A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone.

OBJECTIVE: Evaluate the human abuse potential (HAP) of an experimental, microsphere-in-capsule formu...

Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.

OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent proper...

Smoking status informs about the risk of advanced serrated polyps in a screening population.

BACKGROUND AND STUDY AIMS: Evidence has accumulated that approximately 15 % to 30 % of colorectal ca...

Intravenous Paracetamol Versus Patient-Controlled Analgesia With Morphine for the Pain Management Following Diagnostic Knee Arthroscopy in Trauma Patients: A Randomized Clinical Trial.

BACKGROUND: Most patients undergoing outpatient surgeries have the unpleasant experience of high lev...

Handling Temporality of Clinical Events for Drug Safety Surveillance.

Using longitudinal data in electronic health records (EHRs) for post-marketing adverse drug event (A...

Automated mutual exclusion rules discovery for structured observational codes in echocardiography reporting.

Structured reporting in medicine has been argued to support and enhance machine-assisted processing ...

Non-weight-based enoxaparin dosing subtherapeutic in trauma patients.

BACKGROUND: We report our experience dosing and monitoring enoxaparin with anti-factor Xa activity (...

Ligand-Based Virtual Screening in a Search for Novel Anti-HIV-1 Chemotypes.

In a search for new anti-HIV-1 chemotypes, we developed a multistep ligand-based virtual screening (...

Gradient liquid chromatographic retention time prediction for suspect screening applications: A critical assessment of a generalised artificial neural network-based approach across 10 multi-residue reversed-phase analytical methods.

For the first time, the performance of a generalised artificial neural network (ANN) approach for th...

Clinical evaluation of the newly developed infectious disease/fever screening radar system using the neural network and fuzzy grouping method for travellers with suspected infectious diseases at Narita International Airport Clinic.

Suspect screening of large numbers of emerging contaminants in environmental waters using artificial neural networks for chromatographic retention time prediction and high resolution mass spectrometry data analysis.

The recent development of broad-scope high resolution mass spectrometry (HRMS) screening methods has...

Machine-learning scoring functions to improve structure-based binding affinity prediction and virtual screening.

Docking tools to predict whether and how a small molecule binds to a target can be applied if a stru...

Statistical Machines for Trauma Hospital Outcomes Research: Application to the PRospective, Observational, Multi-Center Major Trauma Transfusion (PROMMTT) Study.

Improving the treatment of trauma, a leading cause of death worldwide, is of great clinical and publ...

Multistage virtual screening and identification of novel HIV-1 protease inhibitors by integrating SVM, shape, pharmacophore and docking methods.

The HIV-1 protease has proven to be a crucial component of the HIV replication machinery and a relia...

Current state of micro-robots/devices as substitutes for screening colonoscopy: assessment based on technology readiness levels.

BACKGROUND: Previous reports have described several candidates, which have the potential to replace ...

Prediction of feature genes in trauma patients with the TNF rs1800629 A allele using support vector machine.

BACKGROUND: Tumor necrosis factor (TNF)-α variant is closely linked to sepsis syndrome and mortality...

Recognition of activities of daily living in healthy subjects using two ad-hoc classifiers.

BACKGROUND: Activities of daily living (ADL) are important for quality of life. They are indicators ...

Experimental design strategy: weak reinforcement leads to increased hit rates and enhanced chemical diversity.

High Throughput Screening (HTS) is a common approach in life sciences to discover chemical matter th...

MLViS: A Web Tool for Machine Learning-Based Virtual Screening in Early-Phase of Drug Discovery and Development.

Virtual screening is an important step in early-phase of drug discovery process. Since there are tho...

Natural language processing as an alternative to manual reporting of colonoscopy quality metrics.

BACKGROUND AND AIMS: The adenoma detection rate (ADR) is a quality metric tied to interval colon can...

Utilizing Telemedicine in the Trauma Intensive Care Unit: Does It Impact Teamwork?

BACKGROUND: The aim of this study was to examine the impact of a telemedical robot on trauma intensi...