Emergency Medicine

Integrating AI Into Emergency Radiology: Promises, Pitfalls, and Practical Approaches.

Emergency radiology operates in a high-acuity, time-sensitive environment where imaging is tightly integrated into real-time clinical decision-making. Growing imaging demand, increasing case complexity, and workforce constraints have intensified pressure on emergency radiologists. Artificial intelligence (AI) has emerged as a potential tool to support imaging prioritization, interpretation, and op...

Advancing safety pharmacology: Emerging technologies, innovative methods, and future directions.

This editorial introduces the annual themed issue of the Journal of Pharmacological and Toxicological Methods (JPTM) dedicated to methodologies in safety pharmacology. The issue draws on content presented at the 2025 Safety Pharmacology Society Annual Meeting in Utrecht, The Netherlands, which featured 124 posters, many of which are reproduced as abstracts in this volume. The manuscripts primarily...

Comparative Phylogenomics and Transcriptional Regulatory Networks of AQPs, HSPs, and LEA Proteins in Salt-Stressed Portulaca oleracea.

Soil salinization severely threatens global food security, necessitating systematic investigations of halophytes like Portulaca oleracea to decode the...

RenalTox-XAI: Applicability-Domain-Constrained and Descriptor-Guided QSAR Framework for Early Screening and Safety Prioritization of Drug-Induced Renal Injury.

Drug-induced renal injury (DIRI) remains a major cause of drug attrition and post-marketing safety concerns, highlighting the need for reliable early-...

Towards Explainability in Deep Learning for Detection of Five Major Intracranial Hemorrhage Subtypes on Head CT Using Multi-window DICOM Imaging and Patient-Level Cross-Validation.

Intracranial hemorrhage (ICH) is a time-critical neurologic emergency where delayed diagnosis can worsen outcomes. Non-contrast head CT is the first-l...

Early Prediction of External Ventricular Drain Weaning Trial Outcome in Patients with SAH Based on ICP Pulse Morphological Similarity: A Single-Center Retrospective Cohort Analysis.

BACKGROUND: External ventricular drain (EVD) weaning trials assess the ability of patients with nontraumatic subarachnoid hemorrhage (SAH) to maintain...

Artificial intelligence for pediatric fracture detection: impact on diagnostic revisions and patient recall rates in a tertiary emergency setting.

PURPOSE: Artificial intelligence (AI) can support and enhance radiologists in musculoskeletal imaging, but evidence of clinical benefit is still lacki...

Preliminary Evaluation of a Dental Virtual Standardized Patient in Endodontic Clinical Reasoning and Decision-Making: Face and Construct Validity.

AIM: To develop and evaluate a dental virtual standardized patient (D-VSP) integrating natural-language intent recognition, a high-fidelity haptic sim...

Forecasting and Capacity Planning in Prehospital Emergency Medical Services: The Case of Ankara.

OBJECTIVE: Time savings in prehospital emergency medical services are vital for human life. Ensuring that these services can meet potential demands is...

Tissue Biology and the Biomechanics of Modern Gastrointestinal Stapling: Principles for Successful Surgical Stapling.

BackgroundThe integration of gastrointestinal (GI) tissue biology with modern stapler mechanics remains a critical gap in optimizing surgical outcomes...

Machine learning reveals temperature as a key predictor of dengue risk across Thailand's provinces: A 20-year analysis.

BACKGROUND: Dengue fever remains a critical public health challenge in Thailand, with transmission dynamics driven by complex interactions between env...

Transforming Orthopaedic Trauma Care: Forecasting Operating Room Demand by Harnessing Time-Series Analysis and Machine Learning.

BACKGROUND: Efficient allocation of operating room (OR) time is critical in trauma centers, where unpredictable volumes lead to wasted resources. Fore...

DINCH induces intestinal toxicity through "ROS-ENO1-PA-lipid peroxidation" axis: An integrated approach combining network toxicology and experimental validation.

Cyclohexane-1,2-dicarboxylic acid diisononyl ester (DINCH), as a "green" alternative to phthalates, has been widely used in consumer products and indu...

Fundamentals of Foundation Models in Radiological Image Processing: Opportunities, Limitations, and Clinical Case Studies.

ABSTRACT: Artificial intelligence (AI) has become firmly established in radiology, with most current applications relying on task-specific convolution...

Long-Term Particulate Matter Exposure and Coronary Inflammation: A Large-Scale Cohort Study Assessed by Pericoronary Fat Attenuation Index.

Particulate matter (PM) is known to accelerate atherosclerosis through systemic inflammation, yet its specific impact on local coronary inflammation r...

The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.

N: (1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), a tire rubber antioxidant derivative, accumulates in air, soil, and water and ha...

Development and Multi-center Validation of a Breathomics-Based Triage Tool for Lung Cancer: A Prospective Study of 5,214 Participants.

BACKGROUND: The inherent false-positive rate of computed tomography (CT) necessitates efficient, non-invasive triage tools to distinguish lung cancer ...

Health databases and early identification of autism spectrum disorder: a scoping review.

OBJECTIVES: To map the available evidence on the use of health databases for the early identification of autism spectrum disorder (ASD) across diverse...

Predictive Modeling of Healthcare Workers' Priorities of the WHO 2030 Key Activities for Snakebite Prevention and Control in Ghana.

Snakebite is a serious public health issue that causes a significant amount of morbidity and mortality. This has led the World Health Organization (WH...

Bisphenol A exposure in myasthenia gravis: Potential targets and mechanisms revealed by network toxicology and molecular dynamics.

BACKGROUND: Myasthenia gravis (MG) is a B-cell-mediated autoimmune disease characterized by impaired neuromuscular transmission. Although genetic pred...