Endocrinology

Latest AI and machine learning research in endocrinology for healthcare professionals.

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RNA-guided contrastive learning enhances patient-level prediction from histology

Predicting molecular receptor status, including estrogen receptor (ER), progesterone receptor (PR), ...

Reconstructing tumor evolution without chromosomal instability reveals in vivo determinants of therapeutic response

Tumor responses to therapy are profoundly shaped by selective pressures operating in vivo, including...

Peer-Grounded Counterfactual Path Planning for Chronic Health Management

Effective behavioral intervention in chronic disease management requires not a single prescription b...

Scaling Network Medicine with LLMs for Combinatorial Drug Repurposing in ER+ Breast Cancer

Drug repurposing can accelerate therapy discovery for ER+ breast cancer, but combination selection r...

Machine Learning for Toxicity Prediction in Low-Sample Molecular Classes

Deep learning models such as Chemprop have advanced quantitative molecular property prediction, but ...

Population-Scale Precision Safety in Oncology Reveals Clinical and Genetic Determinants of Systemic Therapy Toxicity

Treatment toxicity constrains the use of effective cancer therapies, but its clinical and genetic de...

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

Continuous glucose monitoring (CGM) provides high-frequency measurements of glucose dynamics and ena...

Attributing Cohen's d: Training Data Attribution for Disease-Related Effects in Normative Age Biomarkers

Normative age models are trained to predict chronological age in a nominally healthy cohort. Applied...

Deep visual proteomics reveals distinct proximal tubular and glomerular injury programs in experimental diabetic kidney disease

Background: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD). Howe...

AI-Driven Early Detection of Polycystic Ovary Syndrome via Follicle Count

Polycystic Ovary Syndrome is a common endocrine disorder characterized by ovulatory dysfunction, hyp...

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Beyond benchmark accuracy: machine-learning turnover-number predictors require system-level validation

Enzyme turnover numbers (kcat) are essential for kinetic models and enzyme-constrained genome-scale ...

A Multi-Agent Large Language Model Reasoning Engine for Early Detection of Pediatric Growth Disorders

Routine childhood growth surveillance is a cornerstone of pediatric care. Growth pattern abnormaliti...

A Structural FHMM for Interpretable Disease Trajectories in T2DM

In this work, we propose a structural variant of the Factorial Hidden Markov Model (FHMM) for the an...

Primal--Dual Alternating Neural Learning for Timely Classification with Performance Guarantees

Timely risk classification is essential in many clinical monitoring settings, where decisions must b...

Curriculum-Aware Interpolate-then-Refine: Learned Physiological Time-Series Imputation under Realistic Missingness

Imputing physiological time series (arterial blood pressure, blood glucose, etc.) is essential for a...

The urinary-metabolite-based lung cancer index (uLCI): an interpretable machine-learning risk model for early-stage disease

BackgroundFive-year survival from lung cancer exceeds 60% at stage I-II but falls below 10% once met...

PelviNeXt: A Modality-Agnostic Hybrid Network for Pelvic Imaging in Women's Health

Women's health remains substantially under-resourced in medical imaging research, with pelvic pathol...

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