Endocrinology

A case of minimal change nephrotic syndrome with hypothyroidism deterioration.

A 73-year-old woman with Graves' disease underwent total thyroidectomy and was being treated with levothyroxine. She developed edema in the lower region of both legs 1 month before hospitalization. She had a high concentration of urine protein and was hospitalized for further assessment. A urine protein concentration of 4.4 g/day was observed, and she was diagnosed with minimal change nephrotic sy...

A linear functional strategy for regularized ranking.

Regularization schemes are frequently used for performing ranking tasks. This topic has been intensively studied in recent years. However, to be effective a regularization scheme should be equipped with a suitable strategy for choosing a regularization parameter. In the present study we discuss an approach, which is based on the idea of a linear combination of regularized rankers corresponding to ...

Clinical Usefulness of F-18 FDG PET/CT in Papillary Thyroid Cancer with Negative Radioiodine Scan and Elevated Thyroglobulin Level or Positive Anti-thyroglobulin Antibody.

PURPOSE: Elevated thyroglobulin (Tg) levels, along with a negative radioiodine scan, present a clinical problem for the diagnosis of recurrence in pap...

Ginsenoside Rg1 Improves In vitro-produced Embryo Quality by Increasing Glucose Uptake in Porcine Blastocysts.

Ginsenoside Rg1 is a natural compound with various efficacies and functions. It has beneficial effects on aging, diabetes, and immunity, as well as an...

Pharmacokinetic and bioavailability study of angeloylgomisin H in rat plasma by UPLC-MS/MS.

Angeloylgomisin H, as a major lignin in the fruits, was reported to have the potential to improve insulin-stimulated glucose uptake by activating PPAR...

Intact parathormone measurement 1 hour after total thyroidectomy as a predictor of symptomatic hypocalcemia.

OBJECTIVE: Postoperative iPTH assay may predict significant hypocalcemia after thyroid surgery. The present study aimed to evaluate the ability of iPT...

Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL.

Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on hig...

Stress Testing of an Artificial Pancreas System With Pizza and Exercise Leads to Improvements in the System's Fuzzy Logic Controller.

BACKGROUND: Under controlled conditions, the Dose Safety artificial pancreas (AP) system controller, which utilizes "fuzzy logic" (FL) methodology to ...

Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands.

The magnitude of the investment required to bring a drug to the market hinders medical progress, requiring hundreds of millions of dollars and years o...

Classifying Stress From Heart Rate Variability Using Salivary Biomarkers as Reference.

An accurate and noninvasive stress assessment from human physiology is a strenuous task. In this paper, a pattern recognition system to learn complex ...

A Soft Computing Approach to Kidney Diseases Evaluation.

Kidney renal failure means that one's kidney have unexpectedly stopped functioning, i.e., once chronic disease is exposed, the presence or degree of k...

Classification of Medical Datasets Using SVMs with Hybrid Evolutionary Algorithms Based on Endocrine-Based Particle Swarm Optimization and Artificial Bee Colony Algorithms.

The classification and analysis of data is an important issue in today's research. Selecting a suitable set of features makes it possible to classify ...

Participatory approach to the development of a knowledge base for problem-solving in diabetes self-management.

OBJECTIVE: To develop an expandable knowledge base of reusable knowledge related to self-management of diabetes that can be used as a foundation for p...

Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.

Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identi...

Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation.

Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons ...

White adipose tissue cells and the progression of cachexia: inflammatory pathways.

BACKGROUND: Cachexia is a systemic syndrome leading to body wasting, systemic inflammation, and to metabolic chaos. It is a progressive condition, and...

Using local lexicalized rules to identify heart disease risk factors in clinical notes.

Heart disease is the leading cause of death globally and a significant part of the human population lives with it. A number of risk factors have been ...

Classification of diabetes maculopathy images using data-adaptive neuro-fuzzy inference classifier.

Prolonged diabetes retinopathy leads to diabetes maculopathy, which causes gradual and irreversible loss of vision. It is important for physicians to ...

Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.

OBJECTIVE: The purpose of this study is to quantify computerized calcification features from ultrasonography (US) images of thyroid nodules in order t...

Metabolic parameters in type 2 diabetic patients with varying degrees of glycemic control during Ramadan: An observational study.

AIMS/INTRODUCTION: The changes in metabolic parameters in type 2 diabetic patients who fast during Ramadan have not been studied in Singapore. This st...