Endocrinology

Latest AI and machine learning research in endocrinology for healthcare professionals.

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Genomic Determinants of Response to Alpelisib Plus Fulvestrant in the SOLAR-1 Trial.

BACKGROUND: Approximately 40% of patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC) have PIK3CA alterations, which contributes to endocrine therapy resistance. Alpelisib, an α-selective phosphatidylinositol 3-kinase inhibitor and degrader, given in combination with fulvestrant, is approved for the treatment of PIK3...

Apr 10 2026 41967638

Lesion Learning Network with Relation Aware Transformer for Diabetic Retinopathy Grading.

Diabetic Retinopathy (DR) is a leading cause of permanent blindness due to the difficulty of early screening. In this context, deep-learning-based automatic DR grading has the potential to significantly improve the diagnostic efficiency of ophthalmologists. However, accurate DR grading remains challenging due to intra-class variations and small lesions. To address this problem, a Lesion Learning N...

Apr 10 2026 41961568
Glycation and disease: a systematic review of the analytical methods and applications of advanced glycation end products (AGEs) as biomarkers of disease.

Over a century since Louis Camille Maillard first described the reaction that bears his name, advanced glycation end products (AGEs) resulting from th...

Apr 10 2026 41961903
Exposome-wide patterns predict brain health in aging.

Promoting brain health is vital for well-being and reducing healthcare burdens. Brain health as measured with the Brain Age Gap (BAG) - the difference...

Apr 10 2026 41963296
Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome.

A major challenge in deciphering the complex genetic landscape of polycystic ovary syndrome (PCOS) lies in the limited understanding of how susceptibi...

Apr 9 2026 41994484
Enhanced glucose forecasting using recurrent neural network and advanced feature engineering.

The aim of this study is to develop an artificial intelligence (AI)-driven pipeline for forecasting blood glucose levels to mitigate risks associated ...

Apr 9 2026 41957441
Self-enhancement-based perfusion mapping with contrast-enhanced magnetic resonance imaging for PAD assessment.

We developed an automatic self-enhancement-based perfusion mapping (SEPM) method to relatively map the microvascular perfusion level in contrast-enhan...

Apr 9 2026 41966496
Dynamic Surveillance of the Cardiovascular Risk and Identification of Treatment Responders in Type 2 Diabetes Using A Machine Learning-Based Model.

AIMS: To establish a model to predict cardiovascular risk and identify treatment response for patients with type 2 diabetes. METHODS: Data from 11677 ...

Apr 9 2026 41966994
Artificial intelligence-based multi-modal multi-tasks analysis of thyroid ultrasound image features predicts thyroid cancer: a multicenter study.

Thyroid nodule ultrasound (US) images and their features are of great importance in thyroid nodule diagnosis, and can be helpful for radiologists' cli...

Apr 9 2026 41967078
Enhancing Community-Based Nursing Decision Support: Machine Learning Models for Diabetes Risk Prediction Using Home Health Nursing Notes.

OBJECTIVES: This study aimed to identify high-risk factors for type 2 diabetes and develop a machine learning (ML)-based diabetes prediction model usi...

Apr 9 2026 41957825
Objective prediction of siesta based on machine learning and association with obesity.

OBJECTIVES: To predict siesta behavior using machine learning models trained on self-reported and objective data-temperature (T), activity (A), positi...

Apr 9 2026 41963146
Cross-body site microbial interactions influence the human plasma metabolome.

BACKGROUND: The human microbiome profoundly influences the host plasma metabolome and health, but most studies have focused on the gut microbiome in i...

Apr 9 2026 41952172
Mechanistic Design of Graphdiyne-Based Multimodal Sensing Integrating Machine Learning and Photothermal Dynamics for Precision Recognition and On-Demand Inactivation.

Rapid and accurate detection of pathogenic bacteria remains essential for infection control and timely treatment. Here, we report a graphdiyne (GDY)-b...

Apr 9 2026 41955469
Machine learning-based programmed cell death gene signature for prognosis and drug sensitivity in breast cancer.

Breast cancer (BRCA) heterogeneity necessitates robust prognostic biomarkers. Programmed cell death (PCD) serves a key role in tumor progression and t...

Apr 8 2026 42027644
Association Between Breast Arterial Calcifications and Increased Cardiovascular Risk: A Canadian Perspective on Clinical Implications and the Potential Role in Preventive Care.

Breast arterial calcifications (BAC) are associated with increased cardiovascular risk and have been correlated with other methods of cardiovascular r...

Apr 8 2026 41948945
Health Prediction Using Hybrid Deep Learning Models: A Transparent and Interpretable Approach.

Obesity has become alarming globally, with mounting health emergencies related to a number of chronic conditions like cardiovascular disease, diabetes...

Apr 8 2026 41948999
Promise and pitfalls of AI chatbots in complex decision-making for thyroid nodules and papillary thyroid cancer.

INTRODUCTION: Artificial intelligence (AI) chatbots are increasingly used in medicine, but their reliability in scenarios with multiple management opt...

Apr 8 2026 41885289
Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study.

BACKGROUND: Preserved ratio impaired spirometry (PRISm), defined by reduced FEV1 with preserved FEV1/FVC ratio, has been linked to cardiometabolic dis...

Apr 7 2026 41944044
Predictive performance of artificial intelligence algorithms for gestational diabetes mellitus in pregnant women: a protocol for systematic review and meta-analysis.

BACKGROUND: Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that can pose numerous adverse health effects on both mothers an...

Apr 7 2026 41947236
Large-scale AI analysis reveals missed opportunities in albuminuria testing and disease-modifying therapy implementation.

BACKGROUND: Albuminuria is a key diagnostic and prognostic biomarker of chronic kidney disease (CKD), associated with adverse cardiovascular and renal...

Apr 7 2026 41950426
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